木香生化湯과 木香生化湯加鹿茸이 産後回復및 乳汁分泌에 미치는 影響
Effects of Mokhyangsaenghwa-tang and Mokhyangsaenghwa-tang plus Cervi Pantotrichum Cornu on Postpartum Recovery and Lactation
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Abstract
Objective:This study was conducted to investigate the effect of Mokhyangsaenghwa -tang (MS) and Mokhyangsaenghwa-tang plus Cervi Pantotrichum Cornu (MS- C) on postpartum recovery and lactation. Materials and Methods: We used 18-week pregnant Spraque Dawley rats and administered the decoctions of MS and MS-C to rats once a day for 4 days or 8 days. Then we observed changes in the body weight of pup rats and complete blood cell count, liver function test, renal function test, mammary gland tissue, level of serum prolactin, β-casein and WAP of postpartum rats. Result: A significant increase in body weight was observed in MS-C treated pup rats compared with in MS treated group. The levels of WBC and platelet from MS group and MS-C group were decreased compared with the control group. The levels of RBC, hemoglobin and hematocrit from MS group and MS-C group showed statistically significant increases compared with the control group. The levels of protein, albumin from MS group and MS-C group were increased compared with the control group. The levels of BUN, creatinine from MS group and MS-C group did not show statistically significant changes compared with the control group. The mammary gland tissues from MS group and MS-C group showed increased angiogenesis. The levels of serum prolactin from MS group and MS-C group were increased compared with the control group. The expression of β-casein and WAP genes from postpartum rats treated with MS and MS-C was increased. Conclusion: This study shows that MS and MS-C improved postpartum recovery and lactation in rats.
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