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포공영이 난소적출 흰쥐의 성호르몬 변화 및 지질대사에 미치는 영향

Effects of Taraxaci Herba on the Sex Hormon Changes and Lipid Metabolism in the Ovariectomized Rats

조성희|양승정|박경미|김지은
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2015.02|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제28권 제1호|pp. 1-12

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키워드

Menopausal SyndromeLipid MetabolismTaraxaci HerbaSex Hormon Changes
주제분류한의학

초록

Objectives: Taraxaci Herba (TH) have been used in oriental medicine for manycenturies as a heat-clearing, detoxifying and stimulating milk secretion drug. Therefore,the purpose of this study was to investigate the effects of TH on the sex hormonechanges and lipid metabolism in the experimental model. Methods: The experimental model of menopause was induced by bilateral ovariectomyin rats. We used TH extract with freeze-dried and 200±20 g female Sprague-dawleyrats for this Study. The level of serum total cholesterol, serum triglyceride, serumHDL-cholesterol, serum total estrogen, serum progesterone, serum follicle stimulatinghormone (FSH), and body weight were measured. Results: The results of this study were obtained as follows;1. Sample A and Sample B significantly decreased body weight and level of serumtotal cholesterol, and significantly increased level of serum total estrogen as comparedwith control group. 2. Sample A decreased level of serum triglyceride, and was increased level of HDLcholesterol,serum progesterone, serum FSH as compared with control group. 3. Sample B significantly increased level of HDL-cholesterol, serum FSH ascompared with control group. 4. Sample B decreased level of serum triglyceride, and was increased level ofserum progesterone as compared with control group. Conclusions: These results suggest that TH could be applied effectively on thetreatment of menopausal syndrome

Abstract

Objectives: Taraxaci Herba (TH) have been used in oriental medicine for manycenturies as a heat-clearing, detoxifying and stimulating milk secretion drug. Therefore,the purpose of this study was to investigate the effects of TH on the sex hormonechanges and lipid metabolism in the experimental model. Methods: The experimental model of menopause was induced by bilateral ovariectomyin rats. We used TH extract with freeze-dried and 200±20 g female Sprague-dawleyrats for this Study. The level of serum total cholesterol, serum triglyceride, serumHDL-cholesterol, serum total estrogen, serum progesterone, serum follicle stimulatinghormone (FSH), and body weight were measured. Results: The results of this study were obtained as follows;1. Sample A and Sample B significantly decreased body weight and level of serumtotal cholesterol, and significantly increased level of serum total estrogen as comparedwith control group. 2. Sample A decreased level of serum triglyceride, and was increased level of HDLcholesterol,serum progesterone, serum FSH as compared with control group. 3. Sample B significantly increased level of HDL-cholesterol, serum FSH ascompared with control group. 4. Sample B decreased level of serum triglyceride, and was increased level ofserum progesterone as compared with control group. Conclusions: These results suggest that TH could be applied effectively on thetreatment of menopausal syndrome

참고문헌 (36)

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