본문 바로가기
KERD
논문KCI 등재

理中湯이 생쥐에 유발된 갑상선기능저하증에 미치는 영향

Effects of Yijung-tang (YJT) on Experimental Hypothyroidism in Mice

이승호|조성희|이은규|양승정|박경미|송유림
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2017.02|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제30권 제1호|pp. 1-15|DOI https://doi.org/10.15204/jkobgy.2017.30.1.001

0

조회

0

다운로드

1

인용

0

참고문헌

키워드

HypothyroidismYijung-tang (YJT)
주제분류한의학

초록

Objectives: The present study was carried out to investigate the effects of YJT on experimental hypothyroidism induced by sodium perchlorate and methimazolein in mice. Methods: 30 one-month-old C57BL6 mice were decided into 4 groups: 1) normal (n=6), 2) sodium perchlorate and methimazolein-induced hypothyroidism control (n=8), 3) hypothyroidism mice treated with low YJT (n=8), 4) hypothyroidism mice treated with high YJT (n=8). Sodium perchlorate and methimazolein were administered for 4 weeks, YJT (low and high) was administered for 2 weeks after sodium perchlorate and methimazolein were initiated for a total duration of 2 week. The changes were observed : weight of body, T3, T4, TSH, follicular cells in the thyroid tissues, LDL cholesterol, HDL cholesterol, triglyceride and free fatty acid, FBG, AST, ALT and so on. Results: YJT did not affect body weight gain. YJT restored free T4 level decreased by sodium perchlorate and methimazolein and prevented shrinking of follicles and proliferation of follicular cells in the thyroid tissues. In addition, YJT lowered total and LDL cholesterol levels elevated by sodium perchlorate and methimazolein respectively and ameliorated distribution of fat in liver tissues. In addition, the effect on fasting blood glucose (FBG), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were also investigated. Conclusions: These data suggest that YJT can be used to treat woman patients which are accompanied with hypothyroidism relatively safely.

Abstract

Objectives: The present study was carried out to investigate the effects of YJT on experimental hypothyroidism induced by sodium perchlorate and methimazolein in mice. Methods: 30 one-month-old C57BL6 mice were decided into 4 groups: 1) normal (n=6), 2) sodium perchlorate and methimazolein-induced hypothyroidism control (n=8), 3) hypothyroidism mice treated with low YJT (n=8), 4) hypothyroidism mice treated with high YJT (n=8). Sodium perchlorate and methimazolein were administered for 4 weeks, YJT (low and high) was administered for 2 weeks after sodium perchlorate and methimazolein were initiated for a total duration of 2 week. The changes were observed : weight of body, T3, T4, TSH, follicular cells in the thyroid tissues, LDL cholesterol, HDL cholesterol, triglyceride and free fatty acid, FBG, AST, ALT and so on. Results: YJT did not affect body weight gain. YJT restored free T4 level decreased by sodium perchlorate and methimazolein and prevented shrinking of follicles and proliferation of follicular cells in the thyroid tissues. In addition, YJT lowered total and LDL cholesterol levels elevated by sodium perchlorate and methimazolein respectively and ameliorated distribution of fat in liver tissues. In addition, the effect on fasting blood glucose (FBG), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were also investigated. Conclusions: These data suggest that YJT can be used to treat woman patients which are accompanied with hypothyroidism relatively safely.

참고문헌 (41)

  1. Jo BY, "Clinical Thyroidology", pp.231~255 (2001), Korea Medical Book Publishing Company
  2. "Hypothyroidism"[URL]
  3. Gu BS, "Clinical Gynecologic endocology", pp.188~ (2001), Korea Medical Book Publishing Company
  4. Burrow GN, "Reproductive endocrinology", pp.4524~4540 (1986), WB Saunders
  5. Monitor M, "Successful outcome of pregnancy in women with hypothyroidism", Ann Intern Med, 94(1), pp.31~ (1981)
  6. Lindsay AN, "Muticystic ovaties detecteer by sonography in children with hypothyroidism", Am J Dis Child, 134, pp.588~ (1980)
  7. Wiersinga WM, "Thyroid hormone replacement therapy", Horm Res, 56, pp.74~81 (2001)
  8. Do HK, "Nephro-Endocrine system of Korean Medicine", pp.729~ (1993), Korean Medicine Laboratory
  9. The Society of Korean Obstetrics and Gynecology, "Korean Obstetrics and Gynecology(2)", pp.193~198 (2012), Euiseongdang
  10. Ko MG, "Hyundae-Sanghanron", pp.647~649 (2000), Haneuimunhwasa
  11. Hur J., "Donguibogam", pp.382~ (2007), Namsandang
  12. College of Oriental Medicine, Professors of Prescriptionology, "Prescriptionology", pp.232~233 (2003), Yeongrimsa
  13. 서창섭, "LC-MS", MS를 이용한 理中湯의 정량분석 및 항산화 활성, 2013, pp.21(1), 177~185[DOI]
  14. Shin IS, "Gastroprotective effects of Leejung-tang, an oriental traditional herbal formula, on ethanol-induced acute gastric injury in rats", Far J Trait Complement Altern Med, 10, pp.316~323 (2013)
  15. 서희연, "理中湯이 IgE가 과잉생성되고 피부염이 유발된 NC", Nga생쥐에서 IFN-γ 반응에 의한 Th2 세포분화 억제에 미치는 영향, 2009, pp.23(1), 1~22[DOI]
  16. 서희연, "理中湯이 Mite antigen으로 유발된 NC", Nga 생쥐의 아토피 피부염에 미치는 영향, 2011, pp.25(1), 1~27[DOI]
  17. Koh KS, "Studies on the effects of aqua-acupuncture with Yi-Jung-tang extracts on the analgesia, anti-laxative and uropepsin value", J Korean Oriental Med, 5, pp.62~71 (1984)
  18. 이진아, "한약 처방 25종에 대한 항염증 효능 비교 연구", 대한한방부인과학회지, 23(3), pp.101~111 (2010), 대한한방부인과학회
  19. Kim SI, "The Effect of Anjeonlejoong -tang on Hypothyroidism : The Prospective Controlled Clinical Study", Korean J. Orient. Int. Med, (fal), pp.103~110 (2004)
  20. Hwang DC, "Bang-Yak-Hap-Pyun", pp.124~125 (2010), Younglimsa
  21. Tsourdi E, "Hyperthyroidism and Hypothyroidism in Male Mice and Their Effects on Bone Mass, Bone Turnover, and the Wnt Inhibitors Sclerostin and Dickkopf-1", Endocrinology, 156(10), pp.3517~3527 (2015)
  22. Cha BS, "Internal Medicine understood by Pathophysiology Vol.9<Endocrine disease>", pp.69~82 (2008), Jungdam
  23. Guyton AC, "Textbook of medical physiology", pp.906~908 (1986), WB Saunder's Company
  24. 최재영, "PTU로 유발된 흰쥐의 갑상선 기능저하증에 미치는 十全大補湯의 효과", 대한한의학 방제학회지, 24(3), pp.131~152 (2016), 대한한의학방제학회[DOI]
  25. 박은영, "人蔘養榮湯이 PTU로 유발된 Rat의 갑상선기능저하증에 미치는 영향", 대한한방부인과학회지, 28(2), pp.55~75 (2015), 대한한방부인과학회[DOI]
  26. 손지혜, "益氣補血湯 물 추출물이 PTU로 유발된 Rat의 갑상선기능저하증에 미치는 영향", 대한한방부인과학회지, 28(3), pp.54~73 (2015), 대한한방부인과학회[DOI]
  27. 최인구, "眞武湯이 백서의 갑상선기능저하증에 미치는 영향", 대한한방내과학회지, 27(4), pp.879~887 (2006), 대한한방내과학회
  28. Lim BS, "The Effects of Woogwi-eum(Yougui-yin)on the Hypothyroidism of Rats", J Korean Oriental Med, 44(4), pp.26~36 (2000)
  29. 김석중, "滋陰降火湯이 Propylthiouracil(PTU)로 유발된 Rat의 갑상선기능저하증에 미치는 영향", 대한한방부인과학회지, 27(1), pp.41~64 (2014), 대한한방부인과학회[DOI]
  30. 조충식, "大營煎이 흰쥐의 갑상선기능저하증에 미치는 영향", 대한본초학회지, 22(4), pp.35~43 (2007), 대한본초학회
  31. 주정현, "香砂養胃湯이 PTU로 유발된 Rat의 갑상선기능저하와 간손상에 미치는 영향", 동의생리병리학회지, 29(5), pp.394~402 (2015), 한의병리학회[DOI]
  32. 조충식, "當歸四逆湯이 백서의 갑상선기능저하증에 미치는 영향", 대한본초학회지, 22(1), pp.95~102 (2007), 대한본초학회
  33. The compilation committee of Herbalogy, University College of Korean Medicine, "Herbalogy textbook of The national University College of Korean Medicine", pp.376~ (2005), Yeongrimsa
  34. Becker C, "Prophylaxis and treatment of side effects due to iodinated contrast media relevant to radiological practice", Radiologe, 47(9), pp.768~773 (2007)
  35. Nakamura H, "Comparison of methimazole and propylthiouracil in patients with hyperthyroidism caused by Graves' disease", J Clin Endocrinol Metab, 92(6), pp.2157~2162 (2007)
  36. Mansourian AR, "Metabolic pathways of tetraidothyronine and triidothyronine production by thyroid gland : a review of articles", Pak J Biol Sci, 14(1), pp.1~12 (2011)
  37. 김영석, "6-propyl, 2-thiouracil로 유발된 갑상선 기능저하증 동물모델에서 파극천이 갑상선 호르몬 및 갑상선 조직에 미치는 효능", 대한한방내과학회지, 32(3), pp.425~434 (2011), 대한한방내과학회
  38. Isselbacher KJ, "Harrison’s Internal Medicine", pp.2099~2101 (1997), Jungdam
  39. Iwen KA, "Thyroid hormones and the metabolic syndrome", Eur Thyroid J, 2(2), pp.83~92 (2013)
  40. Joffe BI, "Diabetes mellitus and hypothyroidism : Strange bedfellows or mutual companions", World J Diabetes, 5(6), pp.901~904 (2014)
  41. Abd El-Kader SM, "Non-alcoholic fatty liver disease : The diagnosis and management", World J Hepatol, 7(6), pp.846~858 (2015)

관련 논문AI추천

滋陰降火湯이 Propylthiouracil(PTU)로 유발된 Rat의 갑상선기능저하증에 미치는 영향김동철, 김석중대한한방부인과학회 · 대한한방부인과학회지2014 · 제27권 제1호益氣補血湯 물 추출물이 PTU로 유발된 Rat의 갑상선기능저하증에 미치는 영향김동철, 손지혜대한한방부인과학회 · 대한한방부인과학회지2015 · 제28권 제3호2000년 이후 갑상선 기능저하증에 대한 국내 한의학 실험연구 체계적 고찰이민혜, 최유경대한한방내과학회 · 대한한방내과학회지2015 · 제36권 제4호人蔘養榮湯이 PTU로 유발된 Rat의 갑상선기능저하증에 미치는 영향김동철, 박은영대한한방부인과학회 · 대한한방부인과학회지2015 · 제28권 제2호PTU 투여 갑상선기능저하증 유발 랫드모델에서 고용량 MOK 약침의 효능 및 안전성 평가 연구정철, 임우현, 정효원, 황지혜한의병리학회 · 동의생리병리학회지2019 · 제33권 제2호香砂養胃湯이 PTU로 유발된 Rat의 갑상선기능저하와 간손상에 미치는 영향김승모, 주정현, 최홍식한의병리학회 · 동의생리병리학회지2015 · 제29권 제5호

이 간행물의 다른 논문 (6건)

월경통의 한약 주기 요법 치료에 대한 중의학의 임상연구 동향윤영진, 배주은, 박경덕pp. 16-28서울시 강동구 소재 한방병원 한방부인과 외래 환자의 주소증 분석박경선, 이진무, 장준복, 이창훈, 황덕상, 우혜린pp. 29-41국내에서 수행된 난임 관련 한의학 치료 임상연구 경향 고찰김수현, 김동일, 장준복, 이윤재, 소민지, 황덕상pp. 42-55난임한방진료시범사업에 참가한 여성의 스트레스 양상에 대한 연구안인숙, 김동일pp. 56-67다낭성난소증후군 변증도구 개발을 위한 기초연구박은지, 정인철, 김선경, 유정은, 유호룡, 백선은, 장새별pp. 68-84
원문 보기