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파라단백혈증신경병의 임상 및 전기생리학적 특징

Clinical and Electrophysiologic Characteristics of Paraproteinemic Neuropathy

김병조|변소영
대한임상신경생리학회 (The Korean Society for clinical Neurophysiology)|2015.12|Annals of Clinical Neurophysiology|제17권 제2호|pp. 45-52

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참고문헌

키워드

TreatmentDiagnosisPolyneuropathyMonoclonal gammopathyParaproteinemic neuropathy
주제분류신경과학

초록

The paraproteinemia is a disorder in which a single clone of plasma cells (monoclonal gammopathy) is responsible for the proliferation of monoclonal proteins (M-proteins). Approximately 10% of patients with idiopathic peripheral neuropathy have monoclonal gammopathy. Some M-proteins have the properties of an antibody to the components of peripheral nerve myelin, but the pathophysiological relationship between the neuropathy and the M-protein is often obscure. The relationship between peripheral neuropathy and monoclonal gammopathy requires the appropriate neurological and hematological investigations for precise diagnosis and treatment. In this review, we provide an update on the causal associations between peripheral neuropathy and monoclonal gammopathy as well as characteristics of clinical and electrophysiologic features. (Korean J Clin Neurophysiol 2015;17:45-52)

Abstract

The paraproteinemia is a disorder in which a single clone of plasma cells (monoclonal gammopathy) is responsible for the proliferation of monoclonal proteins (M-proteins). Approximately 10% of patients with idiopathic peripheral neuropathy have monoclonal gammopathy. Some M-proteins have the properties of an antibody to the components of peripheral nerve myelin, but the pathophysiological relationship between the neuropathy and the M-protein is often obscure. The relationship between peripheral neuropathy and monoclonal gammopathy requires the appropriate neurological and hematological investigations for precise diagnosis and treatment. In this review, we provide an update on the causal associations between peripheral neuropathy and monoclonal gammopathy as well as characteristics of clinical and electrophysiologic features. (Korean J Clin Neurophysiol 2015;17:45-52)

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