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Diffuse large B-cell lymphoma presenting as transverse myelitis

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초록

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma. Although progressive lymphadenopathy is a typical feature, extranodal involvement may also occur, including the gastrointestinal tract, skin, bone, thyroid, and testes. Central nervous system invasion is rare, so differentiating it from diseases such as inflammatory demyelinating disorder or infection is essential. DLBCL is therefore a challenge to diagnose, especially when the first findings are neurological symptoms. We report an unusual case of DLBCL that presented as transverse myelitis.

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin’s lymphoma. Although progressive lymphadenopathy is a typical feature, extranodal involvement may also occur, including the gastrointestinal tract, skin, bone, thyroid, and testes. Central nervous system invasion is rare, so differentiating it from diseases such as inflammatory demyelinating disorder or infection is essential. DLBCL is therefore a challenge to diagnose, especially when the first findings are neurological symptoms. We report an unusual case of DLBCL that presented as transverse myelitis.

참고문헌 (13)

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  4. Chen Y, "Non-Hodgkin lymphoma with longitudinally extensive transverse myelopathy as the initial symptom : a case report", Front Oncol, 9, pp.266~ (2019)
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  8. Frohman EM, "Clinical practice. Transverse myelitis", N Engl J Med, 363, pp.564~572 (2010)
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  10. Yunoki M, "A case of intravascular lymphoma presenting as myelopathy diagnosed with a skin biopsy", Surg Neurol Int, 6(Suppl 13), pp.S367~S370 (2015)
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  13. HYUN SOO KIM, "Primary central nervous system lymphoma with intramedullary spinal cord involvement mimicking inflammatory demyelinating disease", Journal of Neurocritical Care, 12(1), pp.55~63 (2019), 대한신경집중치료학회[DOI]

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