고콜레스테롤 식이 흰쥐의 과민성방광에서 Aspirin과 Arginine의 병용투여가 방광내압검사와 방광근수축에 미치는 영향
Effects of Aspirin and Arginine on Overactive Bladder of Hypercholesterol diet Rats
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Abstract
Purpose: The purpose of this study was to show the effects of aspirin and arginine on hyperactive bladder of hypercholesterol diet rats. Materials and Methods: We used 40, 3-month-old Sprague-Dawley rats. Ten of them received the 2% cholesterol diet for 8 weeks and 10 received cholesterol diet and aspirin treatment and 10 received cholesterol diet, aspirin and arginine treatment. The remaining 10 served as control and were fed a normal diet. Cystometry and bladder muscle strips study were evaluated in each group. Results: Compared with normal control, mean serum cholesterol and body weight significantly elevated in the cholesterol group. Aspirin +/- arginine treatment lessened the increase of body weight and serum cholesterol level. Compared to control, the cholesterol group showed a shorter voiding interval and smaller functional bladder capacity in cystometrogram, however, aspirin +/- arginine treatment group showed no difference in voiding interval and functional bladder capacity. In detrusor muscle strip study, the increase in the proportion of purinergic components and the decrease in the proportion of cholinergic components were observed in the cholesterol group, however, not in aspirin +/- arginine treatment group. Overall, additional effect of arginine on aspirin treatment was negligible. Conclusion: Treatments of aspirin +/- arginine showed significant protective effect on the bladder overactivity induced by hypercholesterol diet in rats. In patients with heart diseases and overactive bladder, aspirin could be a useful treatment for protection and treatment. (J. Korean Continence Society 2005;9:6-12)
참고문헌 (19)
- "Predictive correlation of urodynamic dysfunction andbrain injury after cerebrovascular accident", 126, pp.86~8 (1981)
- "Lower urinary tract symptom", 85, pp.57~68 (2000)
- "서울 지역40세 이상 남성을 대상으로 한 하부요로증상에 대한 역학조사", 42, pp.840~848 (2001)
- "The effect of short-term obstructionon urinary bladder function in the rabbit", 132, pp.789~91 (1984)
- "Blood flow of theurinary bladder:effects of outlet obstruction and correlationwith bioenergetic metabolism", 14, pp.285~292 (1995)
- "Theeffects of short-term in-vivo ischemia on the contractile functionof the rabbit urinary bladder", 139, pp.1350~4 (1988)
- "Novel unstable bladder model in hypercholesterolemia rat", pp.385~ (2004)
- "Suppression of intimal hyperplasia inexperimental vein grafts by oral l-arginine supplementationand single ex vivo immersion in deferoxamine manganese", 23, pp.410~420 (1996)
- "Aspirintreatment improves bladder function after outlet obstruction inrabbits", 58, pp.608~613 (2001)
- "Cerebral aetiology of urinary urgeincontinence in elderly people", 23, pp.246~50 (1994)
- "Overactivity and structural changes in the chronically ischemicbladder", 162, pp.1768~1778 (1999)
- "Atherosclerosis-induced chronic ischemia causes bladder fibrosis andnon-compliance in the rabbit", 161, pp.1626~1635 (1999)
- "Nitric oxide in the pathogenesis of vasculardisease", 190, pp.244~254 (2000)
- "Clinical importance of endothelial function inarteriosclerosis and ischemic heart disease", 66, pp.529~533 (2002)
- "Aspirin selectively inhibits prostaglandinproduction in human platelets", 23, pp.235~57 (1971)
- "Postoperative adhesion prevention with low-doseaspirin:effect through the selective inhibition of thromboxaneproduction", 13, pp.1486~1489 (1998)
- "Intravesical adenosine triphosphatestimulates the micturition reflex in awake, freely moving rats", 168, pp.1230~1234 (2002)
- "Evidencefor purinergic neurotransmission in human urinary bladderaffected by interstitial cystitis", 150, pp.2007~12 (1993)
- "A quantitative analysis of purinoceptor expressionin human fetal and adult bladders", 165, pp.1730~1734 (2001)