본문 바로가기
KERD
논문KCI 등재

백서 방광 출구 부분 폐색시 경구 투여한 terazosin이 방광의 조직학적 변화에 미치는 효과

The Effect of Terazosin on the histological changes of Rat Bladder after Partial Outlet Obstruction

2

조회

0

다운로드

1

인용

0

참고문헌

초록

Abstract

Purpose: When the bladder outlet is partially obstructed, The expression of iNOS and collagen type III is caused by ischemia of bladder. This study aimed to evaluate the hemodynamic changes and the expression of inducible nitric oxide synthase (iNOS) and collagen type III of bladder during acute stages of partial bladder outlet obstruction in female rats and conducted a research on the effect of α-adrenergic blocker. Materials and Methods: Thirty mature Sprague-Dawley rats were randomly divided into three groups; 3 days (Group I), 7 days (Group II), 14 days (Group III), depending on the term of partial bladder outlet obstruction. After obstruction, each group was subdivided into the experimental groups and the control groups; terazosin (0.4 mg/kg) was administered to the experimental groups and normal saline was administered to the control groups for a week. The degree of expression of iNOS and collagen type III in bladder was investigated by immunohistochemical stain and Western blot. Results: The blood flow of experimental groups showed significant increase compared to control groups (p< 0.05). The expression of iNOS and collagen type III of exerimental groups was significantly decreased compared to the controls (p<0.05). Conclusion: This study suggests that α-adrenergic blocker makes increase in blood flows to bladder and may have a role of prevention from functional damage of bladder. (J. Korean Continence Society 2006;10: 106-115)

참고문헌 (46)

  1. "Stimulation of DNA synthesis in rabbit bladder wall after partial outlet obstruction and acute overdistension", pp.51~61
  2. "Voiding dysfunction in benign prostatic hyper-plasia", 51, pp.73~82 (1998)
  3. "Effects of acute complete urinary obstruc-tion on the NADPH-diaphorase reactivity in the intramural ganglia of the guinea pig urinary bladder", 158, pp.916~923 (1997)
  4. "New insights into the regulation of inducible nitric oxide synthase", pp.829~39
  5. "A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promotor", pp.1683~93, Sica A
  6. "Biochemical characteristics and biological signifi-cance of genetically distinct collagens", pp.165~92
  7. "Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle", pp.104~50
  8. "Collagen and elastin in the obstructed fetal bladder", pp.528~31
  9. "Bladder wall abnormalities in myelodysplastic bladders", pp.1024~9
  10. "Is lamina propria matrix responsible for normal bladder compliance? J Urol 1992;148", pp.544~9, Ewalt DH
  11. "Bladder smooth muscle cells in culture Identification 박정수이창렬이 완이정주대한배뇨장애 및 요실금 학회지 114and characterization"
  12. "Type III collagen decreases in normal fetal bovine bladder development", pp.688~91
  13. "Loss of elasticity in dysfunctional bladders", pp.702~5
  14. "The effect of short-term obstruc-tion on urinary bladder function in the rabbit", pp.789~91
  15. "A urodynamic view of prostatic obstruction and the results of prostatectomy", pp.631~7
  16. "M o r -phological plasticity in efferent pathway to the urinary bladder of the rat following urethral obstruction"
  17. "Decrease in the automatic innervation of human detrusor muscle in outlet obstruction", pp.501~6, Gilpin CJ
  18. "Cystometrical and in vitro evaluation of urinary blader function in rats with streptozosin-induced diabetes", pp.1359~65
  19. "The contractile and metabolic effect of acute ischemia on the rabbit urinary bladder"
  20. "Smooth muscle cell hypertrophy and hyperplasia in the rat detrusor after short-time infravesical outflow obstruction", pp.173~6
  21. "Effect of distension on blood flow in dog’s urinary bladder", pp.210~2
  22. "Changes in canine blader perfusion with distension", pp.149~50
  23. "The functional effect of mild outlet obstruction on the rabbit urinary bladder", pp.880~4, Haugaard N
  24. "Correlation of ischemia and reperfusion or partial outlet obstruction-induced spectrin pro-teolysis by calpain with contractile dysfunction in rabbit bla-der", 49, pp.293~230 (1997)
  25. "Physiologic sequelae of partial infravesical obstruction in the mouse", 161, pp.1015~1022 (1999)
  26. "Measurement of nitric oxide and peroxy-nitrite generation in post ischemic heart", 271, pp.29223~29230 (1996)
  27. "Nitritc oxide synthase in Leydig cells of the human testis", pp.17~30
  28. "non-cholinergic nerve-mediated relaxation of rabbit urethra is caused by nitric oxide", (n-adrenergic), pp.133~4
  29. "nerve-mediated relaxation of rabbit urethra involves nitric oxide", pp.253~9
  30. "nitric oxide synthase", 100, pp.2146~2152 (1997)
  31. "Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endo-thelial cells", 31, pp.1744~1751 (2000)
  32. "정자 운동성에 대한 Nitric Oxide와 Peroxynitrite의 효과", 39, pp.896~902 (1998)
  33. "Nitric oxide induces apoptosis in the human corpus luteum in vitro", 6, pp.681~687 (2000)
  34. "Nitric oxide is a mediator of apoptosis in the rheumatoid joint", 39, pp.1004~1008 (2000)
  35. "Cytostatic elementation of subgeneric rat tumor cells in vitro by nonspecifically activated macrophages", pp.625~44
  36. "Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration", pp.357~70
  37. "The effect of short-term obstruc-tion on urinary bladder function in the rabit", pp.789~91
  38. "Effect of vesical outlet obstruction on detrusor contractility and passive properties in rabbit", pp.1284~9
  39. "Collagen content in the rat urinary bladder subjected to infravesical outflow obstruction", pp.587~90
  40. "Collagen type Ⅰ and III localization by in situ hybridiza-tion immunohistochemistry in the partially obstructed young rabbit bladder", 156, pp.582~586 (1996)
  41. "Effect of physical forces on bladder smooth muscle and urothelium", pp.601~7
  42. "Three-dimensional arrangement of collagen and elastin fibers in the human urinary blader a scanning electron 백서 방광 출구 부분 폐색 시 경구 투여한 Terazosin이 방광의 조직학적 변화에 미치는 효과Vol", shi(y), pp.251~6
  43. "International Union of Pharmacology Recommendation for nomenclature of 1-adrenoreceptor", pp.267~70
  44. "quanti-fication and localization of mRNA for three distinct alpha 1 adrenoreceptor subtypes in human prostate", pp.546~51
  45. "Pharmacological evidence of distinct alpha 1-adrenoreceptor subtypes mediating the contraction of human prostatic urethra and peripheral artery", pp.723~8
  46. "Alpha-blockade"

관련 논문AI추천

정상 흰쥐에서 Phosphodiesterase 4 억제제가 방광 기능에 미치는 영향강택원, 권동득, 류수방, 박광성, 박양일, 오경진, 이정선대한배뇨장애요실금학회 · International Neurourology Journal2005 · 제9권 제2호난소절제술 후 암컷 백서 방광의 생리적, 형태학적 변화 및 호르몬 보충요법길건, 구대용, 김강섭, 김진겸, 나용길, 설종구, 신주현, 임재성대한배뇨장애요실금학회 · International Neurourology Journal2007 · 제11권 제2호과민성 방광모델로서 자연발생 고혈압 쥐에서 비마취하 요역동학 검사로 관찰한 항콜린성 제제인 tolterodine의 배뇨 압력 및 용적에 대한 경구 및 주사 효과이택, 강용진, 권용현, 윤상민, 이소영, 장진혁, 진롱후대한배뇨장애요실금학회 · International Neurourology Journal2009 · 제13권 제2호고콜레스테롤 식이 흰쥐의 과민성방광에서 Aspirin과 Arginine의 병용투여가 방광내압검사와 방광근수축에 미치는 영향구자현, 김수웅, 박관진, 백재승, 손환철, 양지현대한배뇨장애요실금학회 · International Neurourology Journal2005 · 제9권 제1호Effects of Tamsulosin on Urinary Bladder Function and Neuronal Activity in the Voiding Centers of Rats with Cyclophosphamide-induced Overactive Bladder정한, 고일규, 김계환, 김성은, 김창주, 박지현, 신말순, 이정환, 정경진대한배뇨장애요실금학회 · International Neurourology Journal2012 · 제16권 제1호Effects of Combination Treatment of Alpha 1-Adrenergic Receptor Antagonists on Voiding Dysfunction: Study on Target Organs in Overactive Bladder Rats고일규, 김성은, 김창주, 김태형, 문보민, 정경진, 지은상, 진준장, 최현희, 황락경대한배뇨장애요실금학회 · International Neurourology Journal2016 · 제20권 제1호

이 간행물의 다른 논문 (14건)