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논문KCI 등재

과민성방광에서 신경성장인자의 역할과 그 의미

Role of Nerve Growth Factor in Overactive Bladder

김준철
대한배뇨장애요실금학회 (Korean Continence Society)|2009.12|International Neurourology Journal|제13권 제2호|pp. 83-89

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참고문헌

키워드

Overactive bladderNerve growth factor

초록

Overactive bladder (OAB) is defined by the International Continence Society (ICS) as urgency, with or without urge incontinence, usually with frequency and nocturia. There have been many studies about OAB, but the cause and mechanisms are still poorly understood. It has been postulated that nerve growth factor (NGF) provide mechanisms for bidirectional communication between muscle or urothelium and nerve, leading to OAB. NGF is a secretory protein that has a critical role in the development of the peripheral nervous system. The bladder, especially the urothelium can produce NGF, which play a role in afferent sensitization. Elevated NGF levels orchestrate changes in sodium channel expression that, in turn, lower afferent nerve thresholds, to cause urgency, frequency and even urge incontinence. Several experimental and clinical studies have reported that the NGF is involved in bladder dysfunction, abnormal afferent signaling and bladder sensation. The evidences about relationship between NGF and OAB, and the role of NGF in the development of OAB are reviewed and discussed here.

Abstract

Overactive bladder (OAB) is defined by the International Continence Society (ICS) as urgency, with or without urge incontinence, usually with frequency and nocturia. There have been many studies about OAB, but the cause and mechanisms are still poorly understood. It has been postulated that nerve growth factor (NGF) provide mechanisms for bidirectional communication between muscle or urothelium and nerve, leading to OAB. NGF is a secretory protein that has a critical role in the development of the peripheral nervous system. The bladder, especially the urothelium can produce NGF, which play a role in afferent sensitization. Elevated NGF levels orchestrate changes in sodium channel expression that, in turn, lower afferent nerve thresholds, to cause urgency, frequency and even urge incontinence. Several experimental and clinical studies have reported that the NGF is involved in bladder dysfunction, abnormal afferent signaling and bladder sensation. The evidences about relationship between NGF and OAB, and the role of NGF in the development of OAB are reviewed and discussed here.

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Urinary Nerve Growth Factor as a Potential Biomarker of Treatment Outcomes in Overactive Bladder Patients고광진, 김태헌, 서윤석, 성현환, 이규성, 이효석, 조원진대한배뇨장애요실금학회 · International Neurourology Journal2017 · 제21권 제4호Potential Biomarkers for Diagnosis of Overactive Bladder Patients: Urinary Nerve Growth Factor, Prostaglandin E2, and Adenosine Triphosphate고광진, 김태헌, 서윤석, 성현환, 이규성, 이문재, 이효석, 조원진대한배뇨장애요실금학회 · International Neurourology Journal2017 · 제21권 제3호Potential Mechanisms Underlying the Increased Excitability of the Bladder Afferent Pathways in Interstitial Cystitis/Bladder Pain Syndrome김두상대한요로생식기감염학회 · Urogenital Tract Infection2018 · 제13권 제2호Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives김덕윤, 조강준, Anne M. Robertson, Joonbeom Kwon, Kanako Matsuoka, Mamoru Hashimoto, Naoki Yoshimura, Pradeep Tyagi, Sergei Karnup, Tadanobu Kamijo, Zhou Wang대한배뇨장애요실금학회 · International Neurourology Journal2024 · 제28권 제1호Development and Changes with Age of Detrusor Overactivity in Spontaneous Hypertensive Rats as Observed by Simultaneous Registrations of Intravesical and Intraabdominal Pressures이택, 박창신, 신화연, 윤상민, 이훈재, 진롱후, 최보화대한배뇨장애요실금학회 · International Neurourology Journal2011 · 제15권 제4호간질성 방광염에서 염증반응으로 인한 요로점막의 변화배재현, 최훈상대한요로생식기감염학회 · Urogenital Tract Infection2013 · 제8권 제2호

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