간질성 방광염에서 염증반응으로 인한 요로점막의 변화
Urothelial Changes by Inflammation in Interstitial Cystitis/Painful Bladder Syndrome
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic disease. Symptoms of IC are often exacerbated by bladder filling and are associated with various urinary symptoms. IC is diagnosed by exclusion steps for differentiation from other confusable diseases. The pathophysiology and etiology of BPS/IC is not completely understood. IC is generally assumed to involve changes in the bladder wall as well as alterations in both structural abnormality of pain processing and its modulation. Alterations of the bladder wall at the molecular and structural levels in urothelium along with their adjacent structures have been observed in human patients. Bladder nerves, urothelial cells, and smooth muscles are likely to play an important role through active communication with the immune and inflammatory systems. This review provides recent information on patients with PBS/IC and their abnormalities within the bladder.
Abstract
Bladder pain syndrome/interstitial cystitis (BPS/IC) is a chronic disease. Symptoms of IC are often exacerbated by bladder filling and are associated with various urinary symptoms. IC is diagnosed by exclusion steps for differentiation from other confusable diseases. The pathophysiology and etiology of BPS/IC is not completely understood. IC is generally assumed to involve changes in the bladder wall as well as alterations in both structural abnormality of pain processing and its modulation. Alterations of the bladder wall at the molecular and structural levels in urothelium along with their adjacent structures have been observed in human patients. Bladder nerves, urothelial cells, and smooth muscles are likely to play an important role through active communication with the immune and inflammatory systems. This review provides recent information on patients with PBS/IC and their abnormalities within the bladder.
참고문헌 (48)
- Dell JR, "Interstitial cystitis", painful bladder syndrome: appropriate diagnosis and management, 2007, pp.16, 1181~1187
- Abrams P, "Standardisation Sub-committee of the International Conti- Nence Society. The standardisation of terminology of lower urinary tract function: report from the Standardisation Subcommittee of the International Continence Society", Neurourol Urodyn, 21, pp.167~178 (2002)
- Hanno PM, "The diagnosis of interstitial cystitis revisited: lessons learned from the National Institutes of Health Interstitial Cystitis Database study", Urol, 161, pp.553~557 (1999)
- van de Merwe JP, "Diagnostic criteria, classification, and nomenclature for painful bladder syndrome", interstitial cystitis: an ESSIC proposal, 2008, pp.53, 60~67
- Curhan GC, "Epidemiology of interstitial cystitis: a population based study", J Urol, 161, pp.549~552 (1999)
- Warren JW, "Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs", Urology, 57(6 Suppl 1), pp.22~25 (2001)
- Kim YS, "Effects of sensitization on female guinea pig urinary bladder function: in vivo and in vitro studies.", J Urol, 146, pp.454~457 (1991)
- Parsons CL, "Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis)", J Urol, 145, pp.732~735 (1991)
- "Bladder surface glycosaminoglycans is a human epithelial permeability barrier", Surg Gynecol Obstet, 171, pp.493~496 (1990)
- Holm-Bentzen M, "Pathology and pathogenesis of interstitial cystitis", Urology, 29(4 Suppl), pp.8~13 (1987)
- Oravisto KJ, "Interstitial cystitis as an autoimmune disease. A review", Eur Urol, 6, pp.10~13 (1980)
- Leppilahti M, "Interstitial cystitis-like urinary symptoms among patients with Sjögren's syndrome: a population-based study in Finland", Am J Med, 115, pp.62~65 (2003)
- Hanno P, "Diagnosis of interstitial cystitis", J Urol, 143, pp.278~281 (1990)
- Silk MR, "Bladder antibodies in interstitial cystitis", J Urol, 103, pp.307~309 (1970)
- Jokinen EJ, "Antitissue antibodies in interstitial cystitis", Clin Exp Immunol, 11, pp.333~339 (1972)
- Harrington DS, "Interstitial cystitis: bladder mucosa lymphocyte immunophenotyping and peripheral blood flow cytometry analysis", J Urol, 144, pp.868~871 (1990)
- MacDermott JP, "Cellular immunity in interstitial cystitis", J Urol, 145, pp.274~278 (1991)
- Arican O, "Serum levels of TNFalpha, IFN-gamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity", Mediators Inflamm, 2005, pp.273~279 (2005)
- Cai B, "p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65", J Biol Chem, 281, pp.25215~25222 (2006)
- Ambrosino C, "Cell cycle regulation by p38 MAP kinases", Biol Cell, 93, pp.47~51 (2001)
- Bullock AD, "Experimental autoimmune cystitis: a potential murine model for ulcerative interstitial cystitis", J Urol, 148, pp.1951~1956 (1992)
- Sairanen J, "Cyclosporine A and pentosan polysulfate sodium for the treatment of interstitial cystitis: a randomized comparative study", J Urol, 174, pp.2235~2238 (2005)
- Ueda T, "Improvement of interstitial cystitis symptoms and problems that developed during treatment with oral IPD-1151T", J Urol, 164, pp.1917~1920 (2000)
- Bade JJ, "Interstitial cystitis in the Netherlands: prevalence, diagnostic criteria and therapeutic preferences", Urol, 154, pp.2035~2037 (1995)
- Dundore PA, "Mast cell counts are not useful in the diagnosis of nonulcerative interstitial cystitis", J Urol, 155, pp.885~887 (1996)
- Larsen S, "Mast cells in interstitial cystitis", Br J Urol, 54, pp.283~286 (1982)
- Sant GR, "The role of the mast cell in interstitial cystitis", Urol Clin North Am, 21, pp.41~53 (1994)
- Theoharides TC, "Mast cells: the immune gate to the brain", Life Sci, 46, pp.607~617 (1990)
- Stead RH, "Mast cells are closely apposed to nerves in the human gastrointestinal mucosa", Gastroenterology, 97, pp.575~585 (1989)
- Dimitriadou V, "Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells", Neuroscience, 44, pp.97~112 (1991)
- Aldenborg F, "Proliferation and transepithelial migration of mucosal mast cells in interstitial cystitis", Immunology, 58, pp.411~416 (1986)
- Bouchelouche K, "The action of cysteinyl-leukotrienes on intracellular calcium mobilization in human detrusor myocytes", BJU Int, 87, pp.690~696 (2001)
- Pang X, "Altered expression of bladder mast cell growth factor receptor (c-kit) in interstitial cystitis", Urology, 51, pp.939~944 (1998)
- Feltis JT, "Increased mast cells of the bladder in suspected cases of interstitial cystitis: a possible disease marker", J Urol, 138, pp.42~43 (1987)
- Serel TA, "Association between mast cells and bladder carcinoma", Urol Int, 72, pp.299~302 (2004)
- Letourneau R, "Intragranular activation of bladder mast cells and their association with nerve processes in interstitial cystitis", Br J Urol, 77, pp.41~54 (1996)
- Sant GR, "Interstitial Cystitis Clinical Trials Group. A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis", J Urol, 170, pp.810~815 (2003)
- Seshadri P, "Cimetidine in the treatment of interstitial cystitis", Urology, 44, pp.614~616 (1994)
- Elbadawi AE, "Distinctive ultrastructural pathology of nonulcerative interstitial cystitis: new observations and their potential significance in pathogenesis", Urol Int, 56, pp.137~162 (1996)
- Lowe EM, "Increased nerve growth factor levels in the urinary bladder of women with idiopathic sensory urgency and interstitial cystitis", Br J Urol, 79, pp.572~577 (1997)
- "Interstitial cystitis: increased sympathetic innervation and related neuropeptide synthesis", J Urol, 147, pp.587~591 (1992)
- Bonini S, "Nerve growth factor: an important molecule in allergic inflammation and tissue remodelling", Int Arch Allergy Immunol, 118, pp.159~162 (1999)
- Steers WD, "Mechanisms of disease: the role of nerve growth factor in the pathophysiology of bladder disorders", Nat Clin Pract Urol, 3, pp.101~110 (2006)
- Chai TC, "Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis", J Urol, 163, pp.1440~1444 (2000)
- Rosamilia A, "Bladder microvasculature and the effects of hydrodistention in interstitial cystitis", Urology, 57(6 Suppl 1), pp.132~ (2001)
- Wilkinson DR, "Urinary and serologic markers for interstitial cystitis: an update", Curr Urol Rep, 7, pp.414~422 (2006)
- Keay SK, "An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide", Proc Natl Acad Sci U S A, 101, pp.11803~11808 (2004)
- Nickel JC, "Elmiron Study Group. Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis", Urology, 65, pp.654~658 (2005)
