본문 바로가기
KERD
논문KCI 등재

Reversal of Doxorubicin-induced Cardiotoxicity by Using Phytotherapy: A Review

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

주제분류한의학

초록

Doxorubicin as a chemotherapeutic drug is widely used for the treatment of patients with cancer. However, clinical use of this drug is hampered by its cardiotoxicity, which is manifested as electrocardiographic abnormalities, arrhythmias, irreversible degenerative cardiomyopathy and congestive heart failure. The precise mechanisms underlying the cardiotoxicity of doxorubicin are not clear, but impairment of calcium homeostasis, generation of iron complexes, production of oxygen radicals, mitochondrial dysfunction and cell membrane damage have been suggested as potential etiologic factors. Compounds that can neutralize the toxic effect of doxorubicin on cardiac cells without reducing the drug's antitumor activity are needed. In recent years, numerous studies have shown that herbal medicines and bioactive phytochemicals can serve as effective add-on therapies to reduce the cardiotoxic effects of doxorubicin. This review describes different phytochemicals and herbal products that have been shown to counterbalance doxorubicin-induced cardiotoxicity.

Abstract

Doxorubicin as a chemotherapeutic drug is widely used for the treatment of patients with cancer. However, clinical use of this drug is hampered by its cardiotoxicity, which is manifested as electrocardiographic abnormalities, arrhythmias, irreversible degenerative cardiomyopathy and congestive heart failure. The precise mechanisms underlying the cardiotoxicity of doxorubicin are not clear, but impairment of calcium homeostasis, generation of iron complexes, production of oxygen radicals, mitochondrial dysfunction and cell membrane damage have been suggested as potential etiologic factors. Compounds that can neutralize the toxic effect of doxorubicin on cardiac cells without reducing the drug's antitumor activity are needed. In recent years, numerous studies have shown that herbal medicines and bioactive phytochemicals can serve as effective add-on therapies to reduce the cardiotoxic effects of doxorubicin. This review describes different phytochemicals and herbal products that have been shown to counterbalance doxorubicin-induced cardiotoxicity.

참고문헌 (171)

  1. Danesi R, "Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs", Clin Pharmacokinet, 41(6), pp.431~444 (2002)
  2. Wouters KA, "Protecting against anthracycline-induced myocardial damage : a review of the most promising strategies", Br J Haematol, 131(5), pp.561~578 (2005)
  3. Lenneman AJ, "Heart transplant survival outcomes for adriamycin-dilated cardiomyopathy", Am J Cardiol, 111(4), pp.609~612 (2013)
  4. Octavia Y, "Doxorubicin-induced cardiomyopathy : from molecular mechanisms to therapeutic strategies", J Mol Cell Cardiol, 52(6), pp.1213~1225 (2012)
  5. Chua CC, "Multiple actions of pifithrin-α on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells", Am J Physiol-Heart Circ Physiol, 290(6), pp.H2606~H2613 (2006)
  6. L'Ecuyer T, "DNA damage is an early event in doxorubicin-induced cardiac myocyte death", Am J Physiol Heart Circ Physiol, 291(3), pp.H1273~H1280 (2006)
  7. Wattanapitayakul SK, "Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity", Basic Clin Pharmacol Toxicol, 96(1), pp.80~87 (2005)
  8. Merten KE, "Calcineurin activation is not necessary for Doxorubicin-induced hypertrophy in H9c2 embryonic rat cardiac cells : involvement of the phosphoinositide 3-kinase-Akt pathway", J Pharmacol Exp Ther, 319(2), pp.934~940 (2006)
  9. Lushnikova E, "Morphological manifestations of heart remodeling in anthracycline-induced dilated cardiomyopathy", Bull Exp Biol Med, 138(6), pp.607~612 (2004)
  10. Oliveira PJ, "Carvedilol-mediated antioxidant protection against doxorubicin-induced cardiac mitochondrial toxicity", Toxicol Appl Pharmacol, 200(2), pp.159~168 (2004)
  11. Spallarossa P, "Carvedilol prevents doxorubicin-induced free radical release and apoptosis in cardiomyocytes in vitro", J Mol Cell Cardiol, 37(4), pp.837~846 (2004)
  12. Swain SM, "Cardioprotection with dexrazoxane for doxorubicin-containing therapy in advanced breast cancer", J Clin Oncol, 15(4), pp.1318~1332 (1997)
  13. Nazish J, "Cardioprotective and antilipidemic potential of Cyperus rotundus in chemically induced cardiotoxicity", Int J Agric Biol, 14(6), pp.989~992 (2012)
  14. Hina S, "Cardioprotective effect of gemmotherapeutically treated Withania somnifera against chemically induced myocardial injury", Pak J Bot, 42(2), pp.1487~1499 (2010)
  15. Branco AF, "Differentiation-dependent doxorubicin toxicity on H9c2 cardiomyoblasts", Cardiovasc Toxicol, 12(4), pp.326~340 (2012)
  16. Dorsey JF, "Aloe(-emodin)for cancer? More than just a comforting salve", Cancer Biol Ther, 6(1), pp.89~90 (2007)
  17. Zhang R, "Rhapontigenin from Rheum undulatum protects against oxidative-stress-induced cell damage through antioxidant activity", J Toxicol Environ Health A, 70(13), pp.1155~1166 (2007)
  18. Hosseini A, "Protective effect of Rheum turkestanikum root against doxorubicin-induced toxicity in H9c2 cells", Rev Bras de Farmacogn, 26(3), pp.347~351 (2016)
  19. Goreja W., "Black seed: nature's miracle remedy: Karger Publishers; 2003. Ahmed MA, Hassanein KM. Cardio protective effects of Nigella sativa oil on lead induced cardio toxicity: Anti inflammatory and antioxidant mechanism", J Physiol Pathophysiol, 4(5), pp.72~80 (2013)
  20. Ebru U, "Cardioprotective effects of Nigella sativa oil on cyclosporine A‐induced cardiotoxicity in rats", Basic Clin Pharmacol Toxicol, 103(6), pp.574~580 (2008)
  21. Nicoll R, "Ginger (Zingiber officinale Roscoe):a hot remedy for cardiovascular disease?", Int J Cardio, 131(3), pp.408~409 (2009)
  22. Bafna P, "Antioxidant activity of DHC‐1, an herbal formulation, in experimentally‐induced cardiac and renal damage", Phytothe Res, 19(3), pp.216~221 (2005)
  23. Nakagawa K, "Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-Ay mice", Biol Pharm Bull, 27(11), pp.1775~1778 (2004)
  24. Lim WYA, "Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats", Lipids Health Dis, 8(1), pp.31~ (2009)
  25. Hosseini A, "Combination of Nigella sativa with Glycyrrhiza glabra and Zingiber officinale augments their protective effects on doxorubicin-induced toxicity in h9c2 cells", Iran J Basic Med Sci, 17(12), pp.993~ (2014)
  26. Mahmoud F, "In vitro effects of Ginkgolide B on lymphocyte activation in atopic asthma : comparison with cyclosporin A", Jpn J Pharmacol, 83(3), pp.241~245 (2001)
  27. Gao J, "Ginkgolide B exerts cardioprotective properties against doxorubicin-Induced cardiotoxicity by regulating reactive oxygen species, akt and calcium signaling pathways in vitro and in vivo", PloS one, 11(12), pp.e0168219~ (2016)
  28. Abraham SVPI, "Antiquorum sensing and antibiofilm potential of Capparis spinosa", Arch Med Res, 42(8), pp.658~668 (2011)
  29. Boga C, "On the antibacterial activity of roots of Capparis spinosa L", Nat Prod Res, 25(4), pp.417~421 (2011)
  30. Siracusa L, "Phenolic composition and antioxidant activity of aqueous infusions from Capparis spinosa L. and Crithmum maritimum L. before and after submission to a two-step in vitro digestion model", J Agric Food Chem, 59(23), pp.12453~12459 (2011)
  31. Huseini HF, "(Caper)fruit extract in treatment of type 2 diabetic patients : a randomized double-blind placebo-controlled clinical trial", Complement Ther Med, 21(5), pp.447~452 (2013)
  32. Aghel N, "Hepatoprotective activity of Capparis spinosa root bark against CCl4induced hepatic damage in mice", Iran J Pharm Res, pp.285~290 (2010)
  33. Wu J-H, "Part 218 : Cappamensin A, a new in vitro anticancer principle, from Capparis sikkimensis", Bioorganic Med Chem lett, 13(13), pp.2223~2225 (2003)
  34. Argentieri M, "Bioactive compounds from Capparis spinosa subsp", Rupestris. Indust Crops Prod, 36(1), pp.65~69 (2012)
  35. Mousavi SH, "Capparis spinosa reduces Doxorubicin-induced cardio-toxicity in cardiomyoblast cells", Avicenna J Phytomed, 6(5), pp.488~ (2016)
  36. Janbaz KH, "Pharmacological effects of Lactuca serriola L. in experimental model of gastrointestinal, respiratory, and vascular ailments", Evid Based Complement Alternat Med, 2013 (2013)
  37. Hosseini A, "PROTECTIVE EFFECT OF LACTUCA SERRIOLA ON DOXORUBICIN-INDUCED TOXICITY IN H9C2 CELLS", Acta Pol Pharm, 73(3), pp.659~666 (2016)
  38. Chen CC, "Inhibitory effects of Hibiscus Sabdariffa L extract on low‐density lipoprotein oxidation and anti‐ hyperlipidemia in fructose‐fed and cholesterol‐fed rats", J Sci Food Agric, 84(15), pp.1989~1996 (2004)
  39. Ali BH, "Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa L.: a review", Phytother Res, 19(5), pp.369~375 (2005)
  40. Serban C, "Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials", J Hypertension, 33(6), pp.1119~1127 (2015)
  41. Hossein A, "Protective Effect of Hibiscus Sabdariffa on Doxorubicin-induced Cytotoxicity in H9c2 Cardiomyoblast Cells(Spring 2017)", Iran J Pharm Res (2017)
  42. Li J-Z, "Paeoniflorin protects myocardial cell from doxorubicin-induced apoptosis through inhibition of NADPH oxidase", Can J Physiol Pharmacol, 90(12), pp.1569~1575 (2012)
  43. Lu G, "Molecular evidence of the neuroprotective effect of Ginkgo biloba(EGb761)using bax", bcl-2 ratio after brain ischemia in senescence-accelerated mice, strain prone-8, 2006, pp.1090(1), 23~28
  44. Trumbeckaite S, "Effect of Ginkgo biloba extract on the rat heart mitochondrial function", J Ethnopharmacol, 111(3), pp.512~516 (2007)
  45. Liu T-J, "Ginkgo biloba extract 761 reduces doxorubicin-induced apoptotic damage in rat hearts and neonatal cardiomyocytes", Cardiovasc Res, 80(2), pp.227~235 (2008)
  46. Haruenkit SPR, "Investigation of limonoids, flavanones, total polyphenol content and antioxidant activity in seven thai pummelo cultivars", Kasetsart J, 43, pp.458~466 (2009)
  47. Chularojmontri L, "Pummelo protects doxorubicin- induced cardiac cell death by reducing oxidative stress, modifying glutathione transferase expression, and preventing cellular senescence", Evid Based Complement Alternat Med, 2013 (2013)
  48. Chang WT, "Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes", Eur J Pharmacol, 566(1-3), pp.58~66 (2007)
  49. Chang WT, "Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation", J Cell Biochem, 112(10), pp.2873~2881 (2011)
  50. Johnson R, "Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53", mTOR, Molecules, pp.2017, 22(10)[DOI]
  51. Johnson R, "Aspalathin, a dihydrochalcone C-glucoside, protects H9c2 cardiomyocytes against high glucose induced shifts in substrate preference and apoptosis", Mol Nut Food Res, 60(4), pp.922~934 (2016)
  52. Snijman PW, "Antioxidant activity of the dihydrochalcones Aspalathin and Nothofagin and their corresponding flavones in relation to other Rooibos(Aspalathus linearis)Flavonoids, Epigallocatechin Gallate, and Trolox", J Agric Food Chem, 57(15), pp.6678~6684 (2009)
  53. Priyadarsini KI, "Free radical studies of ellagic acid, a natural phenolic antioxidant", J Agric Food Chem, 50(7), pp.2200~2206 (2002)
  54. Türk G, "Improvement of cisplatin-induced injuries to sperm quality, the oxidant-antioxidant system, and the histologic structure of the rat testis by ellagic acid", Fertil Steril, 89(5), pp.1474~1481 (2008)
  55. Corbett S, "Evaluation of the anti-inflammatory effects of ellagic acid", J Perianesth Nurs, 25(4), pp.214~220 (2010)
  56. Kannan MM, "Ellagic acid ameliorates isoproterenol induced oxidative stress : Evidence from electrocardiological, biochemical and histological study", Eur J Pharmacol, 659(1), pp.45~52 (2011)
  57. Warpe VS, "Cardioprotective effect of ellagic acid on doxorubicin induced cardiotoxicity in wistar rats", J Acute Med, 5(1), pp.1~8 (2015)
  58. Sheena N, "Anti-inflammatory and anti-nociceptive activities of Ganoderma lucidum occurring in South India", Pharm Biol, 41(4), pp.301~304 (2003)
  59. Jones S, "Antioxidant and antitumor activity of Ganoderma lucidum (Curt.: Fr.) P. Karst.—Reishi (Aphyllophoromycetideae) from South India", Int J Med Mushrooms, 2(3) (2000)
  60. Han X, "Protective effect of naringenin-7-O-glucoside against oxidative stress induced by doxorubicin in H9c2 cardiomyocytes", Biosci Trends, 6(1), pp.19~25 (2012)
  61. Sheena N, "Reishi from South India against doxorubicin-induced cardiotoxicity in rats", Orient Pharm Exp Med, 5(1), pp.62~68 (2005)
  62. Putri H, "Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model", Asian Pac J Trop Biomed, 3(5), pp.371~375 (2013)
  63. Prashanth D, "Antibacterial activity of Punica granatum", Fitoterapia, 72(2), pp.171~173 (2001)
  64. Ross RG, "Immunomodulatory activity of Punica granatum in rabbits—a preliminary study", J Ethnopharmacol, 78(1), pp.85~87 (2001)
  65. Chidambara Murthy KN, "Studies on antioxidant activity of pomegranate(Punica granatum)peel extract using in vivo models", J Agric Food Chem, 50(17), pp.4791~4795 (2002)
  66. Hassanpour Fard M, "Cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat", Pharm Biol, 49(4), pp.377~382 (2011)
  67. Xia E-Q, "Biological activities of polyphenols from grapes", Int J Mol Sci, 11(2), pp.622~646 (2010)
  68. Khoshbaten M, "Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change", Saudi J Gastroenterol, 16(3), pp.194~ (2010)
  69. Najafi M, "Study the effects of hydroalcoholic extract of grape seed(Vitis vinifera)on infarct size and cardiac arrhythmias in ischemic-reperfused isolated rat heart", Pharmaceut Sci, 16, pp.187~194 (2011)
  70. Babaei H, "Effect of supplementation with grape seed extract(vitis vinifera)on serum lipid profiles in patient with type 2 diabetes", Iran J Endocrin Metab, 15(1), pp.59~66 (2013)
  71. Bagchi D, "Free radical scavenging, antioxidant and cancer chemoprevention by grape seed proanthocyanidin : An overview", Mutat Res, 768, pp.69~73 (2014)
  72. Bagchi D, "Free radicals and grape seed proanthocyanidin extract : importance in human health and disease prevention", Toxicol, 148(2), pp.187~197 (2000)
  73. Razmaraii N, "Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats", Adv Pharm Bull, 6(3), pp.423~ (2016)
  74. Arthan D, "Antiviral isoflavo-noid sulfate and steroidal glycosides from the fruits of Solanum torvum", Phytochem, 59(4), pp.459~463 (2002)
  75. Israf D, "Enhancement of ovalbumin-specific IgA responses via oral boosting with antigen co-administered with an aqueous Solanum torvum extract", Life Sci, 75(4), pp.397~406 (2004)
  76. Sivapriya M, "Isolation and purification of a novel antioxidant protein from the water extract of Sundakai (Solanum torvum) seeds", Food Chem, 104(2), pp.510~517 (2007)
  77. Nguelefack TB, "Anti-ulcerogenic properties of the aqueous and methanol extracts from the leaves of Solanum torvum Swartz(Solanaceae)in rats", J Ethnopharmacol, 119(1), pp.135~140 (2008)
  78. Václavíková R, "The effect of flavonoid derivatives on doxorubicin transport and metabolism", Bioorganic Med Chem, 16(4), pp.2034~2042 (2008)
  79. Kamble S, "Protective effect of Solanum torvum on doxorubicininduced cardiactoxicity in rats", Pharmacologyonline, 2, pp.1192~1204 (2009)
  80. Komolafe K, "Methanolic leaf extract of Parkia biglobosa protects against doxorubicin-induced cardiotoxicity in rats", Int J Appl Res Nat Prod, 6(3), pp.39~47 (2013)
  81. Millogo-Kone H, "Comparative study of leaf and stem bark extracts of Parkia biglobosa against enterobacteria", Afr J Tradit Complement Altern Med, 5(3), pp.238~243 (2008)
  82. Atanu F, "A review of the pharmacological aspects of Solanum nigrum Linn", Biotechnol Mol Biol Rev, 6(1), pp.1~8 (2011)
  83. Ravi V, "Anti-inflammatory effect of methanolic extract of Solanum nigrum Linn berries", Int J Appl Res Nat Prod, 2(2), pp.33~36 (2009)
  84. Patel S, "In-vitro cytotoxicity activity of Solanum nigrum extract against Hela cell line and Vero cell line", Int J Pharm Pharm Sci, 1(1), pp.38~46 (2009)
  85. Kumar V, "Exploration of hepatoprotective activity of aqueous extract of Solanum nigrum-an experimental study", Int J Pharm Sci Res, 4(1), pp.464~ (2013)
  86. Nitish B, "Evaluation of cardio protective Activity of Methanolic Extract Of Solanum Nigrum Linn. in Rats", Int J Drug Dev Res (2011)
  87. Varshney P, "Cardioprotective effect of Solanum nigrum against doxorubicin induced cardiotoxicity-an experimental study", Int J Basic Clin Pharmacol, 5(3), pp.748~753 (2016)
  88. Frank J, "Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men", J Nutr, 139(1), pp.58~62 (2009)
  89. Zheng J, "Cardioprotective effects of epigallocatechin-3-gallate against doxorubicin-induced cardiomyocyte injury", Eur J Pharmacol, 652(1), pp.82~88 (2011)
  90. Khan G, "Cardioprotective effect of green tea extract on doxorubicin-induced cardiotoxicity in rats", Acta Pol Pharm, 71(5), pp.861~868 (2014)
  91. Mishra L-C, "Scientific basis for the therapeutic use of Withania somnifera(ashwagandha) : a review", Altern Med Rev, 5(4), pp.334~346 (2000)
  92. Scartezzini P, "Review on some plants of Indian traditional medicine with antioxidant activity", J Ethnopharmacol, 71(1), pp.23~43 (2000)
  93. Jahanbakhsh SP, "Evaluation of the efficacy of Withania somnifera(Ashwagandha)root extract in patients with obsessive-compulsive disorder : A randomized double-blind placebo-controlled trial", Complement Ther Med, 27, pp.25~29 (2016)
  94. Dhuley JN, "RETRACTED : adaptogenic and cardioprotective action of ashwagandha in rats and frogs", J Ethnopharmacol, 70(1), pp.57~63 (2000)
  95. Davis L, "Effect of Withania somnifera on cyclophosphamide-induced urotoxicity", Cancer lett, 148(1), pp.9~17 (2000)
  96. Hamza A, "The protective effect of a purified extract of Withania somnifera against doxorubicin-induced cardiac toxicity in rats", Cell Biol Toxicol, 24(1), pp.63~73 (2008)
  97. Fryer RA, "Recent advances and developments in treatment strategies against pancreatic cancer", Curr Clin Pharmacol, 4(2), pp.102~112 (2009)
  98. Maheshwari RK, "Multiple biological activities of curcumin : a short review", Life Sci, 78(18), pp.2081~2087 (2006)
  99. Ramsewak R, "Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I–III from Curcuma longa", Phytomed, 7(4), pp.303~308 (2000)
  100. Ganjali S, "Effects of curcumin on HDL functionality", Pharmacol Res, 119, pp.208~218 (2017)
  101. Ganjali S, "Investigation of the effects of curcumin on serum cytokines in obese individuals : a randomized controlled trial", TheScientificWorldJournal, 2014, pp.898361~ (2014)
  102. Mirzaei H, "Curcumin: A new candidate for melanoma therapy?", Int J Cancer, 139(8), pp.1683~1695 (2016)
  103. Panahi Y, "Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis : Results of a Randomized Controlled Trial", J Diet Suppl, 13(2), pp.209~220 (2016)
  104. Panahi Y, "Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication : Positive Results of a Randomized Double-blind Placebo-controlled Trial", Drug Res, 65(11), pp.567~573 (2015)
  105. Panahi Y, "Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome : A randomized controlled trial and an updated meta-analysis", Clin Nutr, 34(6), pp.1101~1108 (2015)
  106. Panahi Y, "Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease : A Randomized Controlled Trial", J Cardiovasc Pharmacol, 68(3), pp.223~229 (2016)
  107. Rahmani S, "Treatment of Non-alcoholic Fatty Liver Disease with Curcumin : A Randomized Placebocontrolled Trial", Phytother Res : PTR, 30(9), pp.1540~1548 (2016)
  108. Sahebkar A, "Curcuminoids for the management of hypertriglyceridaemia", Nat Rev Cardiol, 11(2), pp.123~ (2014)
  109. Sahebkar A, "Curcumin downregulates human tumor necrosis factor-alpha levels : A systematic review and meta-analysis ofrandomized controlled trials", Pharmacol Res, 107, pp.234~242 (2016)
  110. El-Sayed EM, "Cardioprotective effects of Curcuma longa L. extracts against doxorubicin-induced cardiotoxicity in rats", J Med Plants Res, 5(17), pp.4049~4058 (2011)
  111. Alavizadeh SH, "Bioactivity assessment and toxicity of crocin : a comprehensive review", Food Chem Toxicol, 64, pp.65~80 (2014)
  112. Jam IN, "The effects of crocin on the symptoms of depression in subjects with metabolic syndrome", Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 26(6), pp.925~930 (2017)
  113. Hosseinzadeh H, "Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice", I International Symposium on Saffron Biology and Biotechnology, 650 (2003)
  114. Pitsikas N, "Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety", Phytomed, 15(12), pp.1135~1139 (2008)
  115. Ghadrdoost B, "Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats", Eur J Pharmacol, 667(1), pp.222~229 (2011)
  116. Khalili M, "Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats", Iran Biomed J, 14(1-2), pp.59~ (2010)
  117. Razmaraii N, "Crocin treatment prevents doxorubicin-induced cardiotoxicity in rats", Life Sci, 157, pp.145~151 (2016)
  118. Goodman J, "Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin", Biochem Biophysic Res Communications, 77(2), pp.797~803 (1977)
  119. Protective effect of Gingko biloba extract against doxorubicin-induced cardiotoxicity in mice, "Naidu M", ~ (2002)
  120. Devi V, "Effect of Phyllanthus niruri on wound healing in rats", Indian J Physiol Pharmacol, 49(4), pp.487~490 (2004)
  121. Islam A, "Antitumour effect of phyllanthin and hypophyllanthin from Phyllanthus amarus against Ehrlich ascites carcinoma in mice", Pharmacologyonline, 2, pp.796~807 (2008)
  122. Joshi H, "Pharmacological evidences for antiamnesic potentials of Phyllanthus amarus in mice", Afr J Biomed Res, 10(2) (2007)
  123. Sharma A, "Estimation of phyllanthin and hypophyllanthin by high performance liquid chromatography in Phyllanthus amarus", Phytochem Analysis, 4(5), pp.226~229 (1993)
  124. Thippeswamy A, "Protective role of Phyllantus niruri extract in doxorubicin-induced myocardial toxicity in rats", Indian J Pharmacol, 43(1), pp.31~ (2011)
  125. Mohajeri SA, "Extraction of crocin from saffron(Crocus sativus)using molecularly imprinted polymer solidphase extraction", J Sep Sci, 33(15), pp.2302~2309 (2010)
  126. Hosseinzadeh H, "Safranal, a constituent of Crocus sativus(saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus", J Pharm Pharm Sci, 8(3), pp.394~399 (2005)
  127. Hosseinzadeh H, "Protective effect of safranal on pentylenetetrazol-induced seizures in the rat : involvement of GABAergic and opioids systems", Phytomed, 14(4), pp.256~262 (2007)
  128. Mousavi SH, "Protective effect of saffron extract and crocin on reactive oxygen species-mediated high glucose-induced toxicity in PC12cells", Cell Mol Neurobiol, 30(2), pp.185~191 (2010)
  129. Ochiai T, "Crocin prevents the death of rat pheochromyctoma(PC-12)cells by its antioxidant effects stronger than those of α-tocopherol", Neurosci lett, 362(1), pp.61~64 (2004)
  130. Hosseinzadeh H, "Crocus sativus L.(Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle", Evid Based Complement Alternat Med, 6(3), pp.343~350 (2009)
  131. Molnar J, "Membrane associated antitumor effects of crocine-, ginsenoside-and cannabinoid derivates", Anticancer Res, 20(2A), pp.861~867 (2000)
  132. Moshiri E, "Crocus sativus L.(petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial", Phytomed, 13(9), pp.607~611 (2006)
  133. "BMC Complement Alternat Med", 2004, 12~
  134. Javadi B, "A survey on saffron in major islamic traditional medicine books", Iran J Basic Med Sci, 16(1), pp.1~11 (2013)
  135. Shafiee M, "Saffron in the treatment of depression, anxiety and other mental disorders : Current evidence and potential mechanisms of action", J Affect Disord, 227, pp.330~337 (2017)
  136. Hosseinzadeh H, "Effects of saffron (Crocus sativus L.) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats", Phytother Res, 26(3), pp.381~386 (2012)
  137. Chahine N, "Protective effect of saffron extract against doxorubicin cardiotoxicity in isolated rabbit heart", Pharm Biol, 51(12), pp.1564~1571 (2013)
  138. Chahine N, "Cardioprotective effect of saffron extracts against acute doxorubicin toxicity in isolated rabbit hearts submitted to ischemia-reperfusion injury", Z Naturforsch C, 69(11-12), pp.459~470 (2014)
  139. Lin S-P, "Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats", J Agric Food Chem, 57(5), pp.1854~1859 (2009)
  140. Sheela M, "Angiogenic and proliferative effects of the cytokine VEGF in Ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra", Int Immunopharmacol, 6(3), pp.494~498 (2006)
  141. Kim J-Y, "Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-κB in RAW 264.7macrophages", Eur J Pharmacol, 584(1), pp.175~184 (2008)
  142. Agarwal R, "Inhibition of mouse skin tumor‐initiating activity of DMBA by chronic oral feeding of glycyrrhizin in drinking water" (1991)
  143. Isbrucker R, "Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin", Regul Toxicol Pharmacol, 46(3), pp.167~192 (2006)
  144. Zhang L, "Cardioprotective effects of Glycyrrhiza uralensis extract against doxorubicin-induced toxicity", Int J Toxicol, 30(2), pp.181~189 (2011)
  145. Ali-Shtayeh MS, "Ethnobotanical survey in the Palestinian area : a classification of the healing potential of medicinal plants", J Ethnopharmacol, 73(1), pp.221~232 (2000)
  146. Shatoor AS, "Azarolus(L)Aqueous Extract Against Doxorubicin-Induced Cardiotoxicity and Heart Failure in Wistar Rats", J Basic Appl Sci Res, 4, pp.102~114 (2014)
  147. Gorinstein S, "Raw and boiled garlic enhances plasma antioxidant activity and improves plasma lipid metabolism in cholesterol-fed rats", Life Sci, 78(6), pp.655~663 (2006)
  148. Al-Numair KS, "Hypocholesteremic and antioxidant effects of garlic (Allium sativum L.) extract in rats fed high cholesterol diet", Pak J Nutr, 8(2), pp.161~166 (2009)
  149. Rahman K., "Historical perspective on garlic and cardiovascular disease", J Nutr, 131(3), pp.977S~979S (2001)
  150. Hosseini A, "A review on the effects of Allium sativum(Garlic)in metabolic syndrome", J Endocrinolo Invest, 38(11), pp.1147~1157 (2015)
  151. Alkreathy H, "Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats", Food Chem Toxicol, 48(3), pp.951~956 (2010)
  152. Wang Y-X, "Effects of doxorubicin on excitation-contraction coupling in guinea pig ventricular myocardium", Circulation Res, 76(4), pp.645~653 (1995)
  153. Okuda T, "Hydrolyzable tannins and related polyphenols", Fortschritte der Chemie organischer Naturstoffe, 1995, 1~117[DOI]
  154. Singal P, "Adriamycin-induced heart failure : mechanisms and modulation", Mol Cell Biochem, 207(1), pp.77~86 (2000)
  155. Manach C, "Polyphenols : food sources and bioavailability", Am J Clin Nutr, 79(5), pp.727~747 (2004)
  156. Rather SA, "Protective effect of gallic acid on immobilization induced stress in encephalon and myocardium of male albino Wistar rats", Int J Nutr, Pharmacol, Neurol Dis, 3(3), pp.269~ (2013)
  157. Kulkarni J, "Cardioprotective effect of gallic acid against doxorubicin-induced myocardial toxicity in albino rats", Indian J Health Sci Biomed Res, 8(1), pp.28~ (2015)
  158. Banerjee S, "Zingiber officinale : ‘a natural gold’", Int J Pharmaceutical Bio-Sci, 2, pp.283~294 (2011)
  159. Gala AAA, "Protective effect of Zingiber officinale(ginger)on doxorubicin induced oxidative cardiotoxicity in rats", Life Sci J (2013)
  160. Kumar MV, "Effect of different extracts of Centella asiatica on cognition and markers of oxidative stress in rats", J Ethnopharmacol, 79(2), pp.253~260 (2002)
  161. Incandela L, "Modification of the echogenicity of femoral plaques after treatment with total triterpenic fraction of Centalla asiatica: A prospective, randomized, placebo-controlled trial", Angiology, 52, pp.S69~ (2001)
  162. De Sanctis M, "Treatment of edema and increased capillary filtration in venous hypertension with total triterpenic fraction of Centella asiatica: A clincial, prospective, placebo-controlled, randomized, dose-ranging trial", Angiology, 52, pp.S55~ (2001)
  163. Inamdar P, "Determination of biologically active constituents in Centella asiatica", J Chromatogr A, 742(1-2), pp.127~130 (1996)
  164. Gnanapragasam A, "Protective effect of Centella asiatica on antioxidant tissue defense system against adriamycin induced cardiomyopathy in rats", Life Sci, 76(5), pp.585~597 (2004)
  165. Radhakrishnan R, "Terminalia arjuna, an Ayurvedic cardiotonic, increases contractile force of rat isolated atria", Phytother Res, 7(3), pp.266~268 (1993)
  166. Bharani A, "Efficacy of Terminalia arjuna in chronic stable angina : a double-blind, placebo-controlled, crossover study comparing Terminalia arjuna with isosorbide mononitrate", Indian Heart J, 54(2), pp.170~175 (2002)
  167. Singh N, "Mechanism of cardiovascular action of Terminalia arjuna", Planta Med, 45(06), pp.102~104 (1982)
  168. Singh G, "Protective effects of Terminalia arjuna against Doxorubicin-induced cardiotoxicity", J Ethnopharmacol, 117(1), pp.123~129 (2008)
  169. Wu SJ, "Antioxidant activities of some common ingredients of traditional chinese medicine, Angelica sinensis, Lycium barbarum and Poria cocos", Phytother Res, 18(12), pp.1008~1012 (2004)
  170. Luo Q, "Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum", Life Sci, 76(2), pp.137~149 (2004)
  171. Xin YF, "Protective effect of Lycium barbarum on doxorubicin‐induced cardiotoxicity", Phytother Res, 21(11), pp.1020~1024 (2007)

관련 논문AI추천

Pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity윤호중, Woo-Baek Chung대한내과학회 · The Korean Journal of Internal Medicine2016 · 제31권 제4호Comparative Study of the Protective Effects of Citral, Thymoquinone, and Silymarin on Methotrexate-induced Cardiotoxicity in RatsAhmadi Nasrollah, Behdokht Barzan, Foad Noorbakhsh Mohammad, Saeed Nazifi, Sakineh Amani대한약침학회 · Journal of Pharmacopuncture2024 · 제27권 제3호Cardioprotective Effect of Peperomia pellucida against Doxorubicin-Induced Cardiotoxicity in Wistar Rats via Modulation of Electrocardiographic and Cardiac BiomarkersDaniel Udofia Owu, Efiok Aniekan Archibong, Glory Aidam Ikum, Idara Asuquo Okon, Justin Atiang Beshel, Stella Chiamaka Anaba대한약침학회 · Journal of Pharmacopuncture2024 · 제27권 제4호Comparative Evaluation of the Preventive Effects of Citral, Silymarin, Thymoquinone, and Curcumin on 5-Fluorouracil-Induced Cardiac and Pulmonary Toxicity in RatsMohammad Foad Noorbakhsh, Nasrollah Ahmadi, Nazifi Saeed, Oryan Ahmad, Tohid Zahed대한약침학회 · Journal of Pharmacopuncture2024 · 제27권 제4호Diagnosis, Treatment, and Prevention of Cardiovascular Toxicity Related to Anti-Cancer Treatment in Clinical Practice: An Opinion Paper from the Working Group on Cardio-Oncology of the Korean Society of Echocardiography김봉준, 김은경, 김학진, 김형섭, 박성미, 서정숙, 윤호중, 이주희, 정우백, 조경임한국심초음파학회 · Journal of Cardiovascular Imaging2018 · 제26권 제1호Renoprotective Effect of Plantago major Against Proteinuria and Apoptosis Induced by Adriamycin in RatAbolfazl Khajavi Rad, Ali Reza Ebrahimzadeh Bideskan, Mohammad Naser Shafei, Nazanin Entezari Heravi, Reza Mohebbati, Samira Shahraki, Sara Hosseinian, Somayeh Mahzari, Zahra Samadi Noshahr, Zohreh Naji Ebrahimi Yazd대한약침학회 · Journal of Pharmacopuncture2019 · 제22권 제1호

이 간행물의 다른 논문 (4건)