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Diagnosis, Treatment, and Prevention of Cardiovascular Toxicity Related to Anti-Cancer Treatment in Clinical Practice: An Opinion Paper from the Working Group on Cardio-Oncology of the Korean Society of Echocardiography

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초록

Cardiovascular (CV) toxicity associated with anti-cancer treatment is commonly encountered and raises critical problems that oftenresult in serious morbidity or mortality. Most cardiac toxicities are related to the cumulative dose of chemotherapy; however,the type of chemotherapy, concomitant agents, and/or conventional CV risk factors have been frequently implicated in CV toxicity. Approximately half of the patients exhibiting CV toxicity receive an anthracycline-based regimen. Therefore, serologic biomarkersor cardiac imagings are important during anti-cancer treatment for early detection and the decision of appropriate managementof cardiotoxicity. However, given the difficulty in determining a causal relationship, a multidisciplinary collaborativeapproach between cardiologists and oncologists is required. In this review, we summarize the CV toxicity and focus on the role ofcardiac imaging in management strategies for cardiotoxicity associated with anti-cancer treatment.

Abstract

Cardiovascular (CV) toxicity associated with anti-cancer treatment is commonly encountered and raises critical problems that oftenresult in serious morbidity or mortality. Most cardiac toxicities are related to the cumulative dose of chemotherapy; however,the type of chemotherapy, concomitant agents, and/or conventional CV risk factors have been frequently implicated in CV toxicity. Approximately half of the patients exhibiting CV toxicity receive an anthracycline-based regimen. Therefore, serologic biomarkersor cardiac imagings are important during anti-cancer treatment for early detection and the decision of appropriate managementof cardiotoxicity. However, given the difficulty in determining a causal relationship, a multidisciplinary collaborativeapproach between cardiologists and oncologists is required. In this review, we summarize the CV toxicity and focus on the role ofcardiac imaging in management strategies for cardiotoxicity associated with anti-cancer treatment.

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