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加味歸脾湯이 생쥐에 Immobilization Stress 負荷後 血中 Corticosterone과 Histamine 含量 및 免疫能 變化에 미치는 影響

Effects of Kamikwibitang on Serum Levels of Corticosterone and Histamine and Immune Response after Immobilization Stress in Mice

이승준|유심근|위석
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2005.02|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제18권 제1호|pp. 94-110

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Abstract

The purpose of this research was to investigate the effects of Kamikwibitang water extract (KKT) on immobilization stress in C57BL/6J mice. KKT decreased the serum level of histamine and corticosterone increased by immobilization stress. In addition, KKT decreased the cell viability of thymocytes and enhanced the cell viability of splenocytes decreased by immobilization stress. Also, KKT decreased the viability of thymocytes and splenocytes in vitro. KKT decreased DNA fragmentation of splenocytes increased by immobilization stress. KKT decreased the population of thymic CD4+CD8- cells increased by immobilization stress, and did not affect the population of B220+ cells and the population of Thy1+ cells changed by immobilization stress and enhanced the population of splenic CD4-CD8+ cells increased by immobilization stress. KKT enhanced the production of γ-interferon and did not affect the production of interleukin-2 and interleukin-4 decreased by immobilization stress. Also, KKT decreased the phagocytic activity and the level of nitric oxide decreased by immobilization stress. These results indicate that KKT may be useful for the prevention and treatment of stress via suppression of serum histamine and corticosterone level and enhancement of specific-immune response.

참고문헌 (32)

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淸肝解鬱湯이 생쥐에 Immobilization-Stress 및 Cold-Stress 負荷後 血中 Histamine과 Corticosterone 含量 및 免疫能에 미치는 影響강복환, 김송백, 유심근, 정우석대한한방부인과학회 · 대한한방부인과학회지2005 · 제18권 제4호귀비탕이 Stress 부하 후 혈중 호르몬 및 비특이적 면역반응에 미치는 영향송정모, 은재순한의병리학회 · 동의생리병리학회지2004 · 제18권 제1호開鬱種玉湯이 생쥐에 束縛 Stress 負荷後 血中 Hormone 含量과 免疫能 變化에 미치는 影響김덕님, 박철훈, 유심근, 조한백대한한방부인과학회 · 대한한방부인과학회지2004 · 제17권 제1호逍遙散이 생쥐에 Immobilization Stress 負荷 後 血中 免疫能系에 미치는 影響박경미, 박종문, 유심근, 조한백, 홍성은대한한방부인과학회 · 대한한방부인과학회지2003 · 제16권 제3호歸脾湯加減方이 구속 Stress 유발 白鼠에 미치는 영향권혁란, 김기현, 김장현, 장규태대한한방소아과학회 · 대한한방소아과학회지2005 · 제19권 제2호調經種玉湯이 Immobilization Stress를 負荷한 C57BL/6J 생쥐의 免疫系에 미치는 影響김송백, 김주연, 민경헌, 조한백대한한방부인과학회 · 대한한방부인과학회지2004 · 제17권 제4호

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