Exposure to Music and Noise During Pregnancy Influences Neurogenesis and Thickness in Motor and Somatosensory Cortex of Rat Pups
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Purpose: Prenatal environmental conditions affect the development of the fetus. In the present study, we investigated the effects of exposure to music and noise during pregnancy on neurogenesis and thickness in the motor and somatosensory cortex of rat pups. Methods: The pregnant rats in the music-applied group were exposed to 65 dB of comfortable music for 1 hour, once per day, from the 15th day of pregnancy until delivery. The pregnant rats in the noise-applied group were exposed to 95 dB of sound from a supersonic sound machine for 1 hour, once per day, from the 15th day of pregnancy until delivery. After birth, the offspring were left undisturbed together with their mother. The rat pups were sacrificed at 21 days after birth. Results: Exposure to music during pregnancy increased neurogenesis in the motor and somatosensory cortex of rat pups. In contrast, rat pups exposed to noise during pregnancy showed decreased neurogenesis and thickness in the motor and somatosensory cortex. Conclusions: Our study suggests that music and noise during the developmental period are important factors influencing brain development and urogenital disorders.
Abstract
Purpose: Prenatal environmental conditions affect the development of the fetus. In the present study, we investigated the effects of exposure to music and noise during pregnancy on neurogenesis and thickness in the motor and somatosensory cortex of rat pups. Methods: The pregnant rats in the music-applied group were exposed to 65 dB of comfortable music for 1 hour, once per day, from the 15th day of pregnancy until delivery. The pregnant rats in the noise-applied group were exposed to 95 dB of sound from a supersonic sound machine for 1 hour, once per day, from the 15th day of pregnancy until delivery. After birth, the offspring were left undisturbed together with their mother. The rat pups were sacrificed at 21 days after birth. Results: Exposure to music during pregnancy increased neurogenesis in the motor and somatosensory cortex of rat pups. In contrast, rat pups exposed to noise during pregnancy showed decreased neurogenesis and thickness in the motor and somatosensory cortex. Conclusions: Our study suggests that music and noise during the developmental period are important factors influencing brain development and urogenital disorders.
참고문헌 (32)
- Hayashi A, "Maternal stress induces synaptic loss and developmental disabilities of offspring", Int J Dev Neurosci, 16, pp.209~216 (1998)
- Lordi B, "Chronic stress in pregnant rats: effects on growth rate, anxiety and memory capabilities of the offspring", Int J Psychophysiol, 37, pp.195~205 (2000)
- Querleu D, "Fetal hearing", Eur J Obstet Gynecol Reprod Biol, 28, pp.191~212 (1988)
- Abbott A, "Music, maestro, please!", Nature, 416, pp.12~14 (2002)
- Zatorre R, "Music, the food of neuroscience?", Nature, 434, pp.312~315 (2005)
- Rauscher FH, "Improved maze learning through early music exposure in rats", Neurol Res, 20, pp.427~432 (1998)
- Sutoo D, "Music improves dopaminergic neurotransmission: demonstration based on the effect of music on blood pressure regulation", Brain Res, 1016, pp.255~262 (2004)
- Foster NA, "The effect of auditory stimulation on autobiographical recall in dementia", Exp Aging Res, 27, pp.215~228 (2001)
- Pacchetti C, "Active music therapy in Parkinson’s disease: an integrative method for motor and emotional rehabilitation", Psychosom Med, 62, pp.386~393 (2000)
- Turner RP, "The acute effect of music on interictal epileptiform discharges", Epilepsy Behav, 5, pp.662~668 (2004)
- Alladi PA, "Effect of prenatal auditory enrichment on developmental expression of synaptophysin and syntaxin 1 in chick brainstem auditory nuclei", Neuroscience, 114, pp.577~590 (2002)
- Secoli SR, "Chronic prenatal stress affects development and behavioral depression in rats", Stress, 2, pp.273~280 (1998)
- Drago F, "Prenatal stress induces body weight deficit and behavioural alterations in rats: the effect of diazepam", Eur Neuropsychopharmacol, 9, pp.239~245 (1999)
- Rehm S, "Aircraft noise and premature birth", J Sound Vib, 59, pp.133~135 (1978)
- Williams MT, "Stress during pregnancy alters rat offspring morphology and ultrasonic vocalizations", Physiol Behav, 63, pp.337~343 (1998)
- Kruggel F, "Analyzing the neocortical fine-structure", Med Image Anal, 7, pp.251~264 (2003)
- Kim H, "Influence of prenatal noise and music on the spatial memory and neurogenesis in the hippocampus of developing rats", Brain Dev, 28, pp.109~114 (2006)
- 김성은, "Effects of Tamsulosin on Urinary Bladder Function and Neuronal Activity in the Voiding Centers of Rats with Cyclophosphamide-induced Overactive Bladder", International Neurourology Journal, 16(1), pp.13~22 (2012), 대한배뇨장애요실금학회
- 조한삼, "Treadmill exercise alleviates short-term memory impairment in 6-hydroxydopamine-induced Parkinson’s rats", Journal of exercise rehabilitation, 9(3), pp.354~361 (2013), 한국운동재활학회
- Chen DG, "Influence of prenatal musicand touch-enrichment on the IQ, motor development, and behavior of infants", Chin J Psychol, 8, pp.148~151 (1994)
- Arabin B, "Music during pregnancy", Ultrasound Obstet Gynecol, 20, pp.425~430 (2002)
- Gould E, "Stress and hippocampal neurogenesis", Biol Psychiatry, 46, pp.1472~1479 (1999)
- Kadner A, "Low-frequency hearing loss in prenatally stressed rats", Neuroreport, 17, pp.635~638 (2006)
- King S, "The effects of prenatal maternal stress on children’s cognitive development: Project Ice Storm", Stress, 8, pp.35~45 (2005)
- King S, "Prenatal maternal stress from a natural disaster predicts dermatoglyphic asymmetry in humans", Dev Psychopathol, 21, pp.343~353 (2009)
- Laplante DP, "Project Ice Storm: prenatal maternal stress affects cognitive and linguistic functioning in 5 1", 2-year-old children, 2008, pp.47, 1063~1072
- Talge NM, "Early Stress, Translational Research and Prevention Science Network: Fetal and Neonatal Experience on Child and Adolescent Mental Health. Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?", J Child Psychol Psychiatry, 48, pp.245~261 (2007)
- Beversdorf DQ, "Timing of prenatal stressors and autism", J Autism Dev Disord, 35, pp.471~478 (2005)
- Kinney DK, "Prenatal stress and risk for autism", Neurosci Biobehav Rev, 32, pp.1519~1532 (2008)
- Grizenko N, "Relation of maternal stress during pregnancy to symptom severity and response to treatment in children with ADHD", J PsychiatryNeurosci, 33, pp.10~16 (2008)
- Li J, "Attention-deficit", hyperactivity disorder in the offspring following prenatal maternal bereavement: a nationwide follow-up study in Denmark, 2010, pp.19, 747~753
- Flynn ER, "High-fat", fructose feeding during prenatal and postnatal development in female rats increases susceptibility to renal and metabolic injury later in life, 2013, pp.304, D278~D285