The Study About Physical Activity for Subjects With Prevention of Benign Prostate Hyperplasia
0
조회
0
다운로드
7
인용
0
참고문헌
키워드
초록
Purpose: The number of benign prostatic hyperplasia (BPH) subjects has been increasing worldwide, and many studies have been conducted to determine the treatment that can delay drug therapy or surgery. Subsequently, most of these studies involved physical activity (PA) and associated factors. Therefore, we aimed to determine factors associated with BPH prevalence based on a review of past and present studies and to investigate the effect of a healthy lifestyle as a protective factor of BPH occurrence. Methods: We selected 582 subjects aged ≥40 years from an initial 779 subjects recruited from Gyeonggi, Yangpyeong, South Korea, during August 2009 to August 2011. Trained investigators surveyed International Prostate Symptom Score and demographic information, including PA and lifestyle questionnaire during face-to-face interviews; further, they performed digital rectal examination, rectal ultrasonography, and measured prostate-specific antigen levels. The statistical association between PA and BPH was analyzed by logistic regression analysis using multivariable regression models which use categorical variables by the Cochran-Mantel-Haenszel test and continuous variables by the general linear model. Results: Seven statistically significant variables for PA were selected. Regular exercise, frequency of exercise, sedentary time, nonsedentary time, leisure time PA (metabolic equivalent, hr/wk) were not statistically associated with prostate volume but sedentary time (hr/day) was the only factor that showed a significant association in the multivariable model, including a linear effect relationship. Subjects with lower levels of sedentary time (4.5–7.0 hr/day) had a significantly lower risk of BPH (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.52–1.67) than those with a higher sedentary time (>7 hr/day) (OR, 1.72; 95% CI, 0.96–3.09) (P for trend=0.05). Conclusions: Our study showed that reducing sedentary time could have a protective effect and reduce the prevalence of BPH. Further prospective studies with a larger sample size are needed to assess the impact of reducing sedentary time on BPH risk.
Abstract
Purpose: The number of benign prostatic hyperplasia (BPH) subjects has been increasing worldwide, and many studies have been conducted to determine the treatment that can delay drug therapy or surgery. Subsequently, most of these studies involved physical activity (PA) and associated factors. Therefore, we aimed to determine factors associated with BPH prevalence based on a review of past and present studies and to investigate the effect of a healthy lifestyle as a protective factor of BPH occurrence. Methods: We selected 582 subjects aged ≥40 years from an initial 779 subjects recruited from Gyeonggi, Yangpyeong, South Korea, during August 2009 to August 2011. Trained investigators surveyed International Prostate Symptom Score and demographic information, including PA and lifestyle questionnaire during face-to-face interviews; further, they performed digital rectal examination, rectal ultrasonography, and measured prostate-specific antigen levels. The statistical association between PA and BPH was analyzed by logistic regression analysis using multivariable regression models which use categorical variables by the Cochran-Mantel-Haenszel test and continuous variables by the general linear model. Results: Seven statistically significant variables for PA were selected. Regular exercise, frequency of exercise, sedentary time, nonsedentary time, leisure time PA (metabolic equivalent, hr/wk) were not statistically associated with prostate volume but sedentary time (hr/day) was the only factor that showed a significant association in the multivariable model, including a linear effect relationship. Subjects with lower levels of sedentary time (4.5–7.0 hr/day) had a significantly lower risk of BPH (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.52–1.67) than those with a higher sedentary time (>7 hr/day) (OR, 1.72; 95% CI, 0.96–3.09) (P for trend=0.05). Conclusions: Our study showed that reducing sedentary time could have a protective effect and reduce the prevalence of BPH. Further prospective studies with a larger sample size are needed to assess the impact of reducing sedentary time on BPH risk.
참고문헌 (25)
- Parsons JK, "Modifiable risk factors for benign prostatic hyperplasia and lower urinary tract symptoms: new approaches to old problems", J Urol, 178, pp.395~401 (2007)
- 박형근, "한국 노령층의 전립선비대증 유병률: 지역기반 연구", Investigative and Clinical Urology, 50(9), pp.843~847 (2009), 대한비뇨기과학회
- McVary KT, "BPH: epidemiology and comorbidities", Am J Manag Care, 12(5 Suppl), pp.S122~S128 (2006)
- Irwin DE, "Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction", BJU Int, 108, pp.1132~1138 (2011)
- Groves HK, "The incidence of acute urinary retention secondary to BPH is increasing among California men", Prostate Cancer Prostatic Dis, 16, pp.260~265 (2013)
- Hollingsworth JM, "Lower urinary tract symptoms in men", BMJ, 349, pp.g4474~ (2014)
- Lepor H, "Pathophysiology, epidemiology, and natural history of benign prostatic hyperplasia", Rev Urol, 6(Suppl 9), pp.S3~S10 (2004)
- Caine M, "The present role of alpha-adrenergic blockers in the treatment of benign prostatic hypertrophy", J Urol, 136, pp.1~4 (1986)
- Parsons JK, "Alcohol consumption is associated with a decreased risk of benign prostatic hyperplasia", J Urol, 182, pp.1463~1468 (2009)
- Cui Y, "Degarelix versus goserelin plus bicalutamide therapy for lower urinary tract symptom relief, prostate volume reduction and quality of life improvement in men with prostate cancer: a systematic review and meta-analysis", Urol Int, 93, pp.152~159 (2014)
- Parsons JK, "Physical activity, benign prostatic hyperplasia, and lower urinary tract symptoms", Eur Urol, 53, pp.1228~1235 (2008)
- Rohrmann S, "Association of cigarette smoking, alcohol consumption and physical activity with lower urinary tract symptoms in older American men: findings from the third National Health And Nutrition Examination Survey", BJU Int, 96, pp.77~82 (2005)
- Seim A, "The prevalence and correlates of urinary tract symptoms in Norwegian men: the HUNT study", BJU Int, 96, pp.88~92 (2005)
- Schoenfeld MJ, "Treatment patterns in alpha-blocker therapy for benign prostatic hyperplasia", Am J Mens Health, 8, pp.267~272 (2014)
- Meigs JB, "Risk factors for clinical benign prostatic hyperplasia in a community-based population of healthy aging men", J Clin Epidemiol, 54, pp.935~944 (2001)
- Giovannucci E, "Obesity and benign prostatic hyperplasia", Am J Epidemiol, 140, pp.989~1002 (1994)
- Sallis JF, "Physical activity assessment methodology in the Five-City Project", Am J Epidemiol, 121, pp.91~106 (1985)
- Platz EA, "Physical activity and benign prostatic hyperplasia", Arch Intern Med, 158, pp.2349~2356 (1988)
- Speakman M, "Burden of male lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) - focus on the UK", BJU Int (2014)
- Hootman JM, "2008 Physical Activity Guidelines for Americans: an opportunity for athletic trainers", J Athl Train, 4, pp.5~6 (2009)
- Gass R, "Benign prostatic hyperplasia: the opposite effects of alcohol and coffee intake", BJU Int, 90, pp.649~654 (2002)
- Gacci M, "Metabolic syndrome and benign prostatic enlargement: a systematic review and meta-analysis", BJU Int (2014)
- Firas Abdollah, "Metabolic Syndrome and Benign Prostatic Hyperplasia: Evidence of a Potential Relationship, Hypothesized Etiology, and Prevention", Investigative and Clinical Urology, 52(8), pp.507~516 (2011), 대한비뇨기과학회
- Brown DW, "Associations between physical activity dose and health-related quality of life", Med Sci Sports Exerc, 35, pp.890~896 (2004)
- Vignozzi L, "Benign prostatic hyperplasia: a new metabolic disease?", J Endocrinol Invest (2014)