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少腹逐瘀湯이 흰쥐의 적출 자궁에 미치는 영향

A Study on the Effects of Sobokchukeo-Tang on the Isolated Uterine Muscle of Rats

양승정|진천식
대한한방부인과학회 (The Society Of Oriental Obstetrics & Gynecology)|2005.11|대한한방부인과학회지 (The Journal of Oriental Obstetrics ＆ Gynecology)|제18권 제4호|pp. 72-84

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참고문헌

주제분류한의학

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Abstract

Purpose : This study was carried out to investigate the relaxational response to the water extract of Sobokchukeo-Tang(SCT) in isolated uterine muscle in rats. Methods : Segments of uterine muscle obtained from female rats immediately after delivery were mounted in organ baths superfused on a polygraph. The effects of SCT on the tension of potassium induced contracture were studied in rat uterine smooth muscles. All experiments were performed in Krebs-Henseit solution which was aerated with 100% oxygen and kept at 37℃. Results : KCl did not produce contraction in calcium-free solution, but CaCl2 induced concentration-dependent contraction after depolarizing with KCl. SCT inhibited the tonic contraction of uterine muscle as dose dependent manner. And when SCT was pretreated in calcium-free medium, it showed more powerful relaxational effect. The effect of 10㎎/㎖ concentration of SCT was equal to that of 9nM and 70nM of nifedipine and verapamil and the relaxational effect of SCT on rat uterine muscle can be assumed to be concerned with the action of cyclic AMP. But the action mechanism of relaxation on the rat uterine muscles were concerned with the calcium channel. Conclusion : From this study we could suggest that the relaxtional effect of SCT on uterine muscle be available to preventing and curing dysmenorrhea.

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