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Rescue of Heart Failure by Mitochondrial Recovery

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초록

Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further progression of HF. Mitochondria undoubtedly play an important role in the progression of HF, and numerous studies have highlighted mitochondrial components that contribute to HF. This review presents an overview of the role of mitochondrial biogenesis, mitochondrial oxidative stress, and mitochondrial permeability transition pore in HF, discusses ongoing studies that attempt to address the disease through mitochondrial targeting, and provides an insight on how these studies can affect future research on HF treatment.

Abstract

Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further progression of HF. Mitochondria undoubtedly play an important role in the progression of HF, and numerous studies have highlighted mitochondrial components that contribute to HF. This review presents an overview of the role of mitochondrial biogenesis, mitochondrial oxidative stress, and mitochondrial permeability transition pore in HF, discusses ongoing studies that attempt to address the disease through mitochondrial targeting, and provides an insight on how these studies can affect future research on HF treatment.

참고문헌 (71)

  1. Bui AL, "Epidemiology and risk profile of heart failure", Nat Rev Cardiol, 8, pp.30~41 (2011)
  2. Levy D, "Long-term trends in the incidence of and survival with heart failure", N Engl J Med, 347, pp.1397~1402 (2002)
  3. Sowers JR, "Diabetes, hypertension, and cardiovascular disease: an update", Hypertension, 37, pp.1053~1059 (2001)
  4. Gheorghiade M, "Navigating the crossroads of coronary artery disease and heart failure", Circulation, 114, pp.1202~1213 (2006)
  5. Chen HM, "Bladder pain syndrome", interstitial cystitis increase the risk of coronary heart disease, 2014, pp.33, 511~515
  6. Kuzmicic J, "Mitochondrial dynamics: a potential new therapeutic target for heart failure", Rev Esp Cardiol, 64, pp.916~923 (2011)
  7. Jubert Marquez, "Definitely not lost in translation: post-translational modifications of cardiac mitochondrial proteins in cardiovascular disease", Korean Circulation Journal, 46(1), pp.1~12 (2016), 대한심장학회[DOI]
  8. Doenst T, "Cardiac metabolism in heart failure:implications beyond ATP production", Circ Res, 113, pp.709~724 (2013)
  9. Witt H, "Sex-specific pathways in early cardiac response to pressure overload in mice", J Mol Med (Berl), 86, pp.1013~1024 (2008)
  10. Faerber G, "Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction", J Thorac Cardiovasc Surg, 141, pp.492~500.e1 (2011)
  11. Sebastiani M, "Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies", J Am Coll Cardiol, 50, pp.1362~1369 (2007)
  12. Lee SR, "Mitochondrial DNA, mitochondrial dysfunction, and cardiac manifestations", Front Biosci (Landmark Ed), 21, pp.1410~1426 (2016)
  13. Sun CK, "Losartan preserves integrity of cardiac gap junctions and PGC-1alpha gene expression and prevents cellular apoptosis in remote area of left ventricular myocardium following acute myocardial infarction", Int Heart J, 48, pp.533~546 (2007)
  14. Garnier A, "Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles", J Physiol, 551(Pt 2), pp.491~501 (2003)
  15. Li H, "Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy", Proc Natl Acad Sci U S A, 97, pp.3467~3472 (2000)
  16. Wang J, "Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression", Nat Genet, 21, pp.133~137 (1999)
  17. Moens AL, "Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure", J Mol Cell Cardiol, 51, pp.564~569 (2011)
  18. Graham BH, "A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart", muscle isoform of the adenine nucleotide translocator, 1997, pp.16, 226~234
  19. Li Y, "Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase", Nat Genet, 11, pp.376~381 (1995)
  20. Hansson A, "A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts", Proc Natl Acad Sci U S A, 101, pp.3136~3141 (2004)
  21. Rosca MG, "Mitochondrial dysfunction in heart failure", Heart Fail Rev, 18, pp.607~622 (2013)
  22. Yi Cai, "EGCG Blocked Phenylephrin-Induced Hypertrophy in H9C2 Cardiomyocytes, by Activating AMPK-Dependent Pathway", The Korean Journal of Physiology & Pharmacology, 19(3), pp.203~210 (2015), 대한약리학회
  23. Duncker DJ, "Endothelial nitric oxide synthase and cardiac remodelling: location, location, location0?", Cardiovasc Res, 93, pp.383~385 (2012)
  24. Yanagishita T, "Protective effect of captopril on ischemic myocardium", Jpn Circ J, 61, pp.161~169 (1997)
  25. Sun W, "Comparison of the efficacy and safety of different ACE inhibitors in patients with chronic heart failure: a PRISMA-compliant network metaanalysis", Medicine (Baltimore), 95, pp.2554~ (2016)
  26. Lai YC, "SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction", Circulation, 133, pp.717~731 (2016)
  27. Benes J, "Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats", Clin Sci (Lond), 121, pp.29~41 (2011)
  28. Yin M, "Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure", Am J Physiol Heart Circ Physiol, 301, pp.H459~H468 (2011)
  29. Gundewar S, "Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure", Circ Res, 104, pp.403~411 (2009)
  30. Yasunori Suematsu, "LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice", European Journal of Heart Failure, 18(4), pp.386~393 (2016), Wiley-Blackwell[DOI]
  31. Solomon SD, "Influence of ejection fraction on outcomes and efficacy of sacubitril", valsartan (LCZ696) in heart failure with reduced ejection fraction: the prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure (PARADIGM-HF) trial, 2016, pp.9, e002744~
  32. Yao K, "Carvedilol promotes mitochondrial biogenesis by regulating the PGC-1", TFAM pathway in human umbilical vein endothelial cells (HUVECs), 2016, pp.470, 961~966
  33. DeVore AD, "Discharge heart rate and β-blocker dose in patients hospitalized with heart failure: findings from the OPTIMIZE-HF registry", Am Heart J, 173, pp.172~178 (2016)
  34. De Toni L, "Effects of type 5-phosphodiesterase inhibition on energy metabolism and mitochondrial biogenesis in human adipose tissue ex vivo", J Endocrinol Invest, 34, pp.738~741 (2011)
  35. Schwartz BG, "Cardiac uses of phosphodiesterase-5 inhibitors", J Am Coll Cardiol, 59, pp.9~15 (2012)
  36. Moens AL, "Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy", Circulation, 117, pp.2626~2636 (2008)
  37. Chong E, "Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K", AKT, Heart Rhythm, pp.2015, 12[DOI]
  38. Biala A, "Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes", Blood Press, 19, pp.196~205 (2010)
  39. Hafstad AD, "Novel aspects of ROS signalling in heart failure", Basic Res Cardiol, 108, pp.359~ (2013)
  40. Burgoyne JR, "Redox signaling in cardiac physiology and pathology", Circ Res, 111, pp.1091~1106 (2012)
  41. Tsutsui H, "Oxidative stress and mitochondrial DNA damage in heart failure", Circ J, 72(Suppl A), pp.A31~A37 (2008)
  42. Olsen RK, "Redox signalling and mitochondrial stress responses; lessons from inborn errors of metabolism", J Inherit Metab Dis, 38, pp.703~719 (2015)
  43. Lu Z, "PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload", Antioxid Redox Signal, 13, pp.1011~1022 (2010)
  44. Bayeva M, "Mitochondrial dysfunction and oxidative damage to sarcomeric proteins", Curr Hypertens Rep, 12, pp.426~432 (2010)
  45. Kwon SH, "H(2)O(2) regulates cardiac myocyte phenotype via concentrationdependent activation of distinct kinase pathways", J Mol Cell Cardiol, 35, pp.615~621 (2003)
  46. Siwik DA, "Regulation of matrix metalloproteinases by cytokines and reactive oxygen", nitrogen species in the myocardium, 2004, pp.9, 43~51
  47. Goyal BR, "Beneficial role of spironolactone, telmisartan and their combination on isoproterenol-induced cardiac hypertrophy", Acta Cardiol, 67, pp.203~211 (2012)
  48. Dizon LA, "Exercise perspective on common cardiac medications", Integr Med Res, 2, pp.49~55 (2013)
  49. Davogustto G, "Perhexiline, Cardiac energetics, and heart failure: lessons from the first law of thermodynamics", JACC Heart Fail, 3, pp.659~660 (2015)
  50. Zorov DB, "Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release", Physiol Rev, 94, pp.909~950 (2014)
  51. Williams GS, "Mitochondrial calcium and the regulation of metabolism in the heart", J Mol Cell Cardiol, 78, pp.35~45 (2015)
  52. Brustovetsky N, "Mitochondrial ADP", ATP carrier can be reversibly converted into a large channel by Ca2+, 1996, pp.35, 8483~8488
  53. Baines CP, "Voltage-dependent anion channels are dispensable for mitochondrialdependent cell death", Nat Cell Biol, 9, pp.550~555 (2007)
  54. Leung AW, "The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition", J Biol Chem, 283, pp.26312~26323 (2008)
  55. Solesio ME, "Inorganic polyphosphate (polyP) as an activator and structural component of the mitochondrial permeability transition pore", Biochem Soc Trans, 44, pp.7~12 (2016)
  56. Nazareth W, "Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A", J Mol Cell Cardiol, 23, pp.1351~1354 (1991)
  57. Griffiths EJ, "Protection by cyclosporin A of ischemia", reperfusion-induced damage in isolated rat hearts, 1993, pp.25, 1461~1469
  58. Nakagawa T, "Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death", Nature, 434, pp.652~658 (2005)
  59. Periasamy M, "Calcineurin and the heartbeat, an evolving story", J Mol Cell Cardiol, 34, pp.259~262 (2002)
  60. Schreiber SL, "The mechanism of action of cyclosporin A and FK506", Immunol Today, 13, pp.136~142 (1992)
  61. Griffiths EJ, "Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion", Biochem J, 307(Pt 1), pp.93~98 (1995)
  62. Argaud L, "Specific inhibition of the mitochondrial permeability transition prevents lethal reperfusion injury", J Mol Cell Cardiol, 38, pp.367~374 (2005)
  63. Gomez L, "Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice", Am J Physiol Heart Circ Physiol, 293, pp.H1654~H1661 (2007)
  64. Clarke SJ, "Sanglifehrin A acts as a potent inhibitor of the mitochondrial permeability transition and reperfusion injury of the heart by binding to cyclophilin-D at a different site from cyclosporin A", J Biol Chem, 277, pp.34793~34799 (2002)
  65. Javadov SA, "Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition", Cardiovasc Res, 45, pp.360~369 (2000)
  66. Shao H, "Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic", reperfused rat heart: role of cardiolipin, 2008, pp.153, 1641~1649
  67. Rajesh KG, "Antioxidant MCI-186inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression", Am J Physiol Heart Circ Physiol, 285, pp.H2171~H2178 (2003)
  68. Clements-Jewery H, "Mitochondria, the calcium uniporter, and reperfusion-induced ventricular fibrillation", Br J Pharmacol, 149, pp.811~813 (2006)
  69. Javadov S, "NHE-1 inhibition-induced cardioprotection against ischaemia", reperfusion is associated with attenuation of the mitochondrial permeability transition, 2008, pp.77, 416~424
  70. Villa-Abrille MC, "Silencing of cardiac mitochondrial NHE1 prevents mitochondrial permeability transition pore opening", Am J Physiol Heart Circ Physiol, 300, pp.H1237~H1251 (2011)
  71. Liddy KA, "Functional decorations: posttranslational modifications and heart disease delineated by targeted proteomics", Genome Med, 5, pp.20~ (2013)

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