본문 바로가기
KERD
논문KCI 등재

생지황 약침이 정상인의 심박변이도(HRV)에 미치는 영향

The Effects of distilled Rehmannia glutinosa Herbal Acupuncture on the Heart Rate Variability(HRV)

육태한|김락형|송범용|신진철
대한약침학회 (Korean Pharmacopuncture Institute)|2008.03|Journal of Pharmacopuncture|제11권 제1호|pp. 83-97

0

조회

0

다운로드

15

인용

0

참고문헌

키워드

HRVHerbal AcupunctureRehmannia glutinosaautonomic nervous system.
주제분류한의학

초록

Objectives : We investigated the effects of distilled Rehmannia glutinosa Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Rehmannia glutinosa Herbal Acupuncture on the balance of the autonomic nervous system. Methods : We investigated on 58 healthy volunteers consisted of 28 subjects in experiment(distilled Rehmannia glutinosa Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 28 subjects in experiment group were injected distilled Rehmannia glutinosa Herbal Acupuncture at GB21(Kyonjong) and 30 subjects in control group were injected Normal Saline at G21(Kyonjong). except of 2 subjects(in control group) who can't be measured and 6 subjects(2 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally 26 subject in experiment group and 24 subject in control group are studied. We measured HRV by PolyG-I on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 10.0 for windows was used to analyze the data and the paired t-test(in group) and Student t-test(between two groups) were used to verify the result. Results : 1. After distilled Rehmannia glutinosa Herbal Acupuncture injection, Mean HRV is significantly low only for first 5 minute, SDNN is significantly high after 5 minute, Complexity is significantly low only from 20 minute to 25minute. HRV index is significantly high for first 5 minute and from 10 minute to after 10 minute. 2. HRV index of distilled Rehmannia glutinosa Herbal Acupuncture Group significantly increased from 25minute to 30minute, and pNN50 of Rehmannia glutinosa Herbal Acupuncture Group significantly decreased from 20minute to 30minute compared with those of Normal Saline group. 3. After distilled Rehmannia glutinosa Herbal Acupuncture injection, Ln(TP) and Ln(VLF) are significantly high after injection. Normalized LF is significantly high from 5 minute to 20 minute and from 25 minute and 30 minute. Normalized HF is significantly low from 5 minute to 20 minute and from 25 minute and 30 minute. 4. Ln(TP) and Ln(VLF) of distilled Rehmannia glutinosa Herbal Acupuncture Group significantly increased from 20minute to 25minute compared with those of Normal Saline group. Conclusions : The results suggest that Rehmannia glutinosa Herbal Acupuncture in healthy adult man tend to activate the autonomic nervous system and parasympathetic nervous system compared to Normal Saline within normal range.

Abstract

Objectives : We investigated the effects of distilled Rehmannia glutinosa Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Rehmannia glutinosa Herbal Acupuncture on the balance of the autonomic nervous system. Methods : We investigated on 58 healthy volunteers consisted of 28 subjects in experiment(distilled Rehmannia glutinosa Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 28 subjects in experiment group were injected distilled Rehmannia glutinosa Herbal Acupuncture at GB21(Kyonjong) and 30 subjects in control group were injected Normal Saline at G21(Kyonjong). except of 2 subjects(in control group) who can't be measured and 6 subjects(2 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally 26 subject in experiment group and 24 subject in control group are studied. We measured HRV by PolyG-I on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 10.0 for windows was used to analyze the data and the paired t-test(in group) and Student t-test(between two groups) were used to verify the result. Results : 1. After distilled Rehmannia glutinosa Herbal Acupuncture injection, Mean HRV is significantly low only for first 5 minute, SDNN is significantly high after 5 minute, Complexity is significantly low only from 20 minute to 25minute. HRV index is significantly high for first 5 minute and from 10 minute to after 10 minute. 2. HRV index of distilled Rehmannia glutinosa Herbal Acupuncture Group significantly increased from 25minute to 30minute, and pNN50 of Rehmannia glutinosa Herbal Acupuncture Group significantly decreased from 20minute to 30minute compared with those of Normal Saline group. 3. After distilled Rehmannia glutinosa Herbal Acupuncture injection, Ln(TP) and Ln(VLF) are significantly high after injection. Normalized LF is significantly high from 5 minute to 20 minute and from 25 minute and 30 minute. Normalized HF is significantly low from 5 minute to 20 minute and from 25 minute and 30 minute. 4. Ln(TP) and Ln(VLF) of distilled Rehmannia glutinosa Herbal Acupuncture Group significantly increased from 20minute to 25minute compared with those of Normal Saline group. Conclusions : The results suggest that Rehmannia glutinosa Herbal Acupuncture in healthy adult man tend to activate the autonomic nervous system and parasympathetic nervous system compared to Normal Saline within normal range.

참고문헌 (45)

  1. 육창수, "한약학Ⅱ", pp.141~ (1992), 광명의학사
  2. 신민교, "원색임상본초학", pp.218~ (1986), 남산당
  3. 이상인, "한약임상응용", pp.199~355 (1986), 성보사
  4. 신길구, "신씨본초학", pp.92~93 (1981), 수문사
  5. 대한약침학회, "약침요법 시술지침서", pp.13~203 (1999), 대한약침학회
  6. 손인철, "약침요법", pp.17~18 (1999), 일중사
  7. 박정배, "지황수침이 실험적 신성 고혈압 백서의 신장기능에 미치는 영향", 대한침구학회지, 11(1), pp.225~238 (1994)
  8. 하춘자, "생지황의 Water Extract가 Alloxan 부하 생쥐 및 가토의 혈당치에 미치는 영향", 의학연구, 79(1), pp.135~142 (1979)
  9. Akselrod S., "Power spectral analysis of heart rate fluctuation : a quantitative probe of beat-to-beat cardiovascular control", Science, 213, pp.220~222 (1981)
  10. Pomeranz B., "Assessment of autonomic function in humans by heart rate spectral analysis", Am J Physiol, 248, pp.151~153 (1985)
  11. Akselrod S., "Hemodynamic regulation : Investigation by spectral analysis", Am J Physiol, 249, pp.867~875 (1985)
  12. Cowan MJ., "Measurement of heart rate variability", Western J Nursing Res, 17, pp.32~48 (1995)
  13. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiolog, "Heart rate variability : Standards of measurement, physiological interpretation and clinical use", Circulation, 93, pp.1043~1065 (1996)
  14. Cerutti S., "Methods of Parametric Spectral Estimation applied to Biological Signal Processing", Biomed. Meas. Inform. Contr, 1, pp.114~124 (1986)
  15. Haker E., "Effect of sensory stimulation(acupuncture) on sympatheric and parasympathetic activities in healthy subjects", J Autonomic Nervous System, 79, pp.52~59 (2000)
  16. 전국한의과대학 침구․경혈학교실 편저, "침구학", pp.45~635 (1999), 집문당
  17. Mukai S., "Heart rate and blood pressure variabilities during head up tilt", Jappl Physiol, 78(1), pp.212~216 (1995)
  18. 남동현, "연령별 맥박변이도 표준화에 관한 연구", 대한한의진단학회지, 5(2), pp.331~349 (2001)
  19. 손동혁, "마황복용이 정상인의 심박변이도에 미치는 영향", 박사, pp.2006
  20. 이건영, "심박변이도 측정을 통한 수족다한증 환자의 자율신경계 기능평가", 대한한방내과학회지, 11(1), pp.46~51 (2005)
  21. Ouyang H., "Electroacupuncture accelerates gastric emptying in association with changes in vagal activity", Am J Physiol Gastrointest Liver Physiol, 282(2), pp.390~396 (2002)
  22. Porta A., "Assessing baroflex gain from spontaneous variability in conscious dogs : role of causality and respiration", Am J Physiol, 279, pp.2558~2567 (2000)
  23. 黃宮繡, , 編譯, pp.1999
  24. 구정회, "동약학개론", pp.362~363 (1991), 여강출판사
  25. 이창복, "대한식물도감", pp.680~ (1993), 향문사
  26. 유경수, "지황의 수치에 관한 연구", 경희대논문집, 4, pp.233~252 (1965)
  27. 홍선표, "숙지황, 건지황 및 생지황 중 숙지황의 특이성분 검색", Journal of the Korean Society of Analytical Sciences, 6(4), pp.401~404 (1993)
  28. 전병훈, "실험적 혈전증에 미치는 한약재의 항혈전효과에 관한 연구", 대한동의병리학회지, 10(1), pp.72~78 (1996)
  29. 황인진, "三種 地黃 추출물이 배양 심근세포에 미치는 영향", 동의생리병리학회지, 16(6), pp.6~1121 (2002), 대한동의병리학회
  30. Horn EH., "Electronic evaluations of the fetal heart rate patterns preceding fetal death: further observation", Am J Obster Gynecol, 87, pp.824~826 (1995)
  31. Bigger JT., "Frequency domain measures of heart period variability and mortality after myocardial infarction", Cir, 85(1), pp.164~171 (1992)
  32. Saul JP., "Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis", Am J Cardiol, 61, pp.1292~1299 (1988)
  33. 조정진, "직무 스트레스의 심혈관계 질환", 가정의학회지, 23, pp.841~854 (2002)
  34. 김범택, "비만환자에서 심박동수 변화", 가정의학회지, 25, pp.542~546 (2004)
  35. 이용제, "대사증후군과 심박동수 변이와의 관계", 가정의학회지, 23(12), pp.1432~1439 (2003)
  36. 김정아, "주우울증 환자의 심박동 변이 분석", 가정의학회지, 24, pp.1117~1122 (2003)
  37. Yeragani VK., "Fractal dimension of heart rate time series: an effective measure of autonomic function", J Appl Physiol, 75, pp.2429~2438 (1993)
  38. 김정민, "피로를 주소로 내원한 환자의 피로도에 따른 자율신경 변화", 가정의학회지, 25, pp.52~58 (2004)
  39. 김민수, "전침 자극이 정상 성인의 심박변동에 미치는 영향", 대한침구의학회지, 20(4), pp.15~ (2003), 대한침구의학회
  40. 이상훈, "침자극이 뇌졸중 환자의 심박변이도에 미치는 영향", 대한침구의학회지, 23(1), pp.135~143 (2006), 대한침구의학회
  41. 장보형, "이침 요법이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향", 대한침구의학회지, 22(6), pp.173~180 (2005), 대한침구의학회
  42. 김동훈, "神門穴 刺戟과 寒熱性向의 交互作用이 心博變移度에 미치는 影響", 대한침구의학회지, 23(1), pp.25~38 (2006), 대한침구의학회
  43. 임대정, "HRV를 통한 말초성 안면신경마비와 자율신경실조의 상관성 연구", 대한침구학회지, 22(6), pp.51~60 (2005)
  44. 설현, "견정혈 황련해독탕약침이 심박변이율에 미치는 영향", 대한침구학회지, 21(6), pp.37~50 (2004)
  45. 김정신, "少府(HT8) 刺針이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향", 대한침구의학회지, 21(5), pp.227~240 (2004), 대한침구의학회

관련 논문AI추천

산삼 약침이 정상인의 심박변이도(HRV)에 미치는 영향김락형, 노정두, 송범용, 육태한대한약침학회 · Journal of Pharmacopuncture2008 · 제11권 제1호황기 약침이 정상인의 심박변이도(HRV)에 미치는 영향김락형, 송범용, 육태한, 임성택대한한방신경정신과학회 · 동의신경정신과학회지2008 · 제19권 제1호녹용 약침과 산조인 약침이 정상인의 심박변이도(HRV)에 미치는 영향김희준, 송범용, 육태한대한약침학회 · Journal of Pharmacopuncture2009 · 제12권 제3호Sweet Bee Venom과 Bee Venom이 심박변이도(HRV)에 미치는 영향유정석, 육태한, 정한성대한약침학회 · Journal of Pharmacopuncture2008 · 제11권 제1호침 자극이 인체의 자율신경계에 미치는 영향 고찰박영배, 박영재, 이주호대한한의진단학회 · 대한한의진단학회지2011 · 제15권 제2호카페인이 HRV에 미치는 영향과 내관 자침의 효과에 대한 예비연구 : 무작위 이중맹검시험김락형, 남지성, 서의석, 양창섭, 장인수, 정현숙대한한방내과학회 · 대한한방내과학회지2008 · 제29권 제3호

이 간행물의 다른 논문 (17건)

줄기세포의 가능한 원천으로서의 장기표면 봉한소체소광섭, 김민수, 우희종, 홍주영, 강대인, 이병천, 홍수, 남창훈pp. 5-12중완혈에서 취장으로 이어지는 새로운 순환적 연결강대인, 김민수, 소광섭, 김민수, 성백경, V.Ogay, 최천주pp. 13-19암성통증에 대한 SBVP 효과-무작위대조시험, 이중맹검김정선, 유화승pp. 21-29동일 농도(0.1㎎/㎖)의 Sweet Bee Venom과 봉약침의 퇴행성 슬관절염에 대한 임상연구김성철, 장은하, 나원민, 임승일, 이성용pp. 31-40Sweet Bee Venom과 Bee Venom이 심박변이도(HRV)에 미치는 영향유정석, 정한성, 육태한pp. 41-54
원문 보기