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녹용 약침과 산조인 약침이 정상인의 심박변이도(HRV)에 미치는 영향

The Effects of distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture on the Heart Rate Variability

육태한|김희준|송범용
대한약침학회 (Korean Pharmacopuncture Institute)|2009.09|Journal of Pharmacopuncture|제12권 제3호|pp. 31-40

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참고문헌

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HRVPharmacopunctureCervi Pantotrichum CornuZizyphi Spinosi Semen
주제분류한의학

초록

Objective : This study was to investigate the effects of distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture on autonomic nervous system with Heart Rate Variability(HRV). Purpose of the trial was to observe what influence distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture have on the autonomic nervous system. Methods : 60 healthy male volunteers were divided into three groups which consist of two experimental groups such as Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture, and a control group. Study design was a randomized, placebo-controlled, double-blind clinical trial. 20 subjects in experimental group were injected distilled Cervi Pantotrichum Cornu Pharmacopuncture at GB21(Kyonjong), 20 subjects in other experimental group were injected distilled Zizyphi Spinosi Semen Pharmacopuncture and 20 subjects in control group were injected Normal Saline at G21(Kyonjong). One volunteer of each groups were excluded from analysis because of error during measuring HRV. At the end of the study 57 volunteers completed HRV analysis. HRV was measured by QECG-3:LXC3203(LAXTHA Inc. Korea) at P0, P1, P2, P3, P4, P5 and P6 and its time-course dependent change in each group was analyzed using paired t-test, and the difference of HRV fluctuation among two experimental group and a control was evaluated by one way ANOVA(p<0.05). Results : A. Time Domain Analysis 1. Analysis of Mean HRV, SDNN and Complexity After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Mean HRV was significantly decreased only at 20 minutes after injection. SDNN was significantly increased from 15 minute after injection. Complexity was significantly decreased only at 15 minute after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Complexity was significantly decreased at 10, 15 and 30 minutes after injection. 2. Analysis of HRV index, pNN50 After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, pNN50 was significantly decreased at 15, 20 and 25 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture showed significant difference on HRV index and pNN50 at 5 minutes after injection. B. Frequency Domain Analysis 1. Analysis of Ln(TP), Ln(VLF) After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Ln(TP) was significantly increased at 15 and 30 minutes after injection. Ln(VLF) was significantly increased at 10, 15 and 30 minutes after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Ln(VLF) was significantly increased only at 30 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture showed significant difference on Ln(TP) after 5 minutes of injection. Conclusion : Our results suggest that Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture in healthy adult man tend to activate the autonomic nervous system and sympathetic nervous system compared to Normal Saline within normal range.

Abstract

Objective : This study was to investigate the effects of distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture on autonomic nervous system with Heart Rate Variability(HRV). Purpose of the trial was to observe what influence distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture have on the autonomic nervous system. Methods : 60 healthy male volunteers were divided into three groups which consist of two experimental groups such as Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture, and a control group. Study design was a randomized, placebo-controlled, double-blind clinical trial. 20 subjects in experimental group were injected distilled Cervi Pantotrichum Cornu Pharmacopuncture at GB21(Kyonjong), 20 subjects in other experimental group were injected distilled Zizyphi Spinosi Semen Pharmacopuncture and 20 subjects in control group were injected Normal Saline at G21(Kyonjong). One volunteer of each groups were excluded from analysis because of error during measuring HRV. At the end of the study 57 volunteers completed HRV analysis. HRV was measured by QECG-3:LXC3203(LAXTHA Inc. Korea) at P0, P1, P2, P3, P4, P5 and P6 and its time-course dependent change in each group was analyzed using paired t-test, and the difference of HRV fluctuation among two experimental group and a control was evaluated by one way ANOVA(p<0.05). Results : A. Time Domain Analysis 1. Analysis of Mean HRV, SDNN and Complexity After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Mean HRV was significantly decreased only at 20 minutes after injection. SDNN was significantly increased from 15 minute after injection. Complexity was significantly decreased only at 15 minute after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Complexity was significantly decreased at 10, 15 and 30 minutes after injection. 2. Analysis of HRV index, pNN50 After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, pNN50 was significantly decreased at 15, 20 and 25 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture showed significant difference on HRV index and pNN50 at 5 minutes after injection. B. Frequency Domain Analysis 1. Analysis of Ln(TP), Ln(VLF) After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Ln(TP) was significantly increased at 15 and 30 minutes after injection. Ln(VLF) was significantly increased at 10, 15 and 30 minutes after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Ln(VLF) was significantly increased only at 30 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture showed significant difference on Ln(TP) after 5 minutes of injection. Conclusion : Our results suggest that Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture in healthy adult man tend to activate the autonomic nervous system and sympathetic nervous system compared to Normal Saline within normal range.

참고문헌 (30)

  1. Joo YS, "Herbology", pp.545~ (1994), Young-Rim
  2. Shin MK, "Clinical Herbology", pp.643~644 (2000), Young-Rim
  3. Kang YS, "Clinical Proportion Herbo-logy", pp.307~308 (1994), Young-Rim
  4. Journal of Korean Institute of Herbal Acupuncture, "Manual of Herbal Acupuncture", Journal of Korean Institute of Herbal Acupuncture, pp.13~14 (1999)
  5. Son IC, "Herbal Acupuncture", pp.17~18 (1999), Il-Jung
  6. KIM JE, "Miracle of Herbal Acupuncture", pp.173~174 (1987), Keum-kwang
  7. "Acupuncture", pp.235~236 (2008), Jib Moon Dang
  8. Choi HS, "Utilization of HRV of Evaluation for Stress", Stress, 13(2), pp.59~63 (2005)
  9. Cowan MJ, "Measurement of heart rate variability", Western J Nursing Res., 17, pp.32~48 (1995)
  10. Task Force of the European society of Cardiology and the North American Society of Pacing and Electrophysiology, "Heart Rate Variability : Standards of measurement. physiological interpretation and clinical use", Circulation, 93, pp.1043~1065 (1996)
  11. Haker E, "Effect of sensory stimulation(acupuncture) on sympathetic and parasympathetic activities in healthy subjects", J Autonomic Nervous System., 79, pp.52~59 (2000)
  12. Akselrod S, "Hemodynamic regulation : Investigation by spectral analysis", Am J Physiol., 249, pp.867~875 (1985)
  13. Mukai S, "Heart rate and blood pressure variabilities during head up tilt", Jappl Physiol., 78(1), pp.212~216 (1995)
  14. Pomeranz B, "Assessment of autonomic function in humans by heart rate spectral analysis", Am J Physiol., 17, pp.32~48 (1985)
  15. Jeon JM, "Pharmacological Study of Sanjoin Ex", pp.1979
  16. Shin KS, "Autonomic differences between athletes and nonathletes:spectral analysis approach", Med Sci Sports Exerc., 29(11), pp.1482~1490 (1997)
  17. Kamath MV, "Power spectral analysis of heart rate variability: anoninvasive signature of cardiac autonomic function", Crit Rev Biomed Eng., 21(3), pp.245~311 (1993)
  18. Korpelainen JT, "Abnormal heart rate variability reflecting autonomic dysfunction in brainstem infarction", Acta Neurol Scand, 94(5), pp.337~342 (1996)
  19. Yoshioka K, "Relationship between diabetic autonomic neuropathy and peripheral neuropathy as assessed by power spectral analysis of heart rate variations and vibratory perception thresholds", Diabetes Res Clin Pract., 24(1), pp.9~14 (1994)
  20. 설현, "肩井穴 黃連解毒湯藥鍼이 심박변이율(HRV)에 미치는 영향", 대한침구학회지, 21(6), pp.37~50 (2004), 대한침구학회
  21. 김정신, "少府(HT8) 刺針이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향", 대한침구학회지, 21(5), pp.227~240 (2004), 대한침구학회
  22. 송범용, "7구역진단기와 심박변이도의 연관성에 대한 임상연구", 대한침구학회지, 25(1), pp.15~23 (2008), 대한침구학회
  23. Nam DH, "A Study of Gender and Age-related Differences in the Pulse Rate Variability", The Journal of The Korea Institute of Oriental Medical Diagnosis, 5(2), pp.331~349 (2001)
  24. 최창민, "우황청심원이 정상인의 심박변이도에 미치는 영향", 대한한방내과학회지, 28(4), pp.717~726 (2007), 대한한방내과학회
  25. Son DH, "Effect of Mahuang on the Heart Rate Variability in Adults:a Double-Blind, Placebo-Controlled, Randomized Trial", Korean J. Orient.Int. Med., 28(1), pp.105~116 (2007)
  26. 장보형, "이침 요법이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향", 대한침구학회지, 22(6), pp.173~180 (2005), 대한침구학회
  27. 이태호, "InGaAlP 레이저 경피혈액조사가정상성인의 심박변이도에 미치는 영향", 대한한방내과학회지, 25(4), pp.25~33 (2004), 대한한방내과학회
  28. 노정두, "산삼 약침이 정상인의 심박변이도(HRV)에 미치는 영향", 대한약침학회지, 11(1), pp.55~69 (2008), 대한약침학회
  29. 신진철, "생지황 약침이 정상인의 심박변이도(HRV)에 미치는 영향", 대한약침학회지, 11(1), pp.83~97 (2008), 대한약침학회
  30. 이상훈, "침자극이 뇌졸중 환자의 심박변이도에 미치는 영향", 대한침구학회지, 23(1), pp.135~143 (2006), 대한침구학회

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