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Oxidative Stress Biomarkers in Age-Related Lower Urinary Tract Disorders: A Systematic Review

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Purpose: To conduct a systematic review of preclinical and clinical peer-reviewed evidence linking alterations in oxidative stress biomarkers or outcome measures that were also prevalent in specific age-related lower urinary tract (LUT) disorders. Methods: PubMed, Scopus, CINAHL, and Embase were searched for peer-reviewed studies published between January 2000 and March 2021. Animal and human studies that reported on the impact of oxidative stress in age-related LUT disorders through structural or functional changes in the LUT and changes in biomarkers were included. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol was followed. Results: Of 882 articles identified, 21 studies (13 animal; 8 human) met inclusion criteria. Across LUT disorders, common structural changes were increased bladder and prostate weights, ischemic damage, nerve damage and detrusor muscle hypertrophy; common functional changes included decreased bladder contraction, increased bladder sensation and excitability, decreased perfusion, and increased inflammation. The disorders were associated with increased levels of biomarkers of oxidative stress that provided evidence of either molecular damage, protective mechanisms against oxidative stress, neural changes, or inflammation. In all cases, the effect on biomarkers and enzymes was greater in aged groups compared to younger groups. Conclusions: Increased oxidative stress, often associated with mitochondrial dysfunction, plays a significant role in the pathogenesis of age-related LUT disorders and may explain their increasing prevalence. This systematic review identifies potential markers of disease progression and treatment opportunities; further research is warranted to evaluate these markers and the mechanisms by which these changes may lead to age-related LUT disorders.

Abstract

Purpose: To conduct a systematic review of preclinical and clinical peer-reviewed evidence linking alterations in oxidative stress biomarkers or outcome measures that were also prevalent in specific age-related lower urinary tract (LUT) disorders. Methods: PubMed, Scopus, CINAHL, and Embase were searched for peer-reviewed studies published between January 2000 and March 2021. Animal and human studies that reported on the impact of oxidative stress in age-related LUT disorders through structural or functional changes in the LUT and changes in biomarkers were included. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) protocol was followed. Results: Of 882 articles identified, 21 studies (13 animal; 8 human) met inclusion criteria. Across LUT disorders, common structural changes were increased bladder and prostate weights, ischemic damage, nerve damage and detrusor muscle hypertrophy; common functional changes included decreased bladder contraction, increased bladder sensation and excitability, decreased perfusion, and increased inflammation. The disorders were associated with increased levels of biomarkers of oxidative stress that provided evidence of either molecular damage, protective mechanisms against oxidative stress, neural changes, or inflammation. In all cases, the effect on biomarkers and enzymes was greater in aged groups compared to younger groups. Conclusions: Increased oxidative stress, often associated with mitochondrial dysfunction, plays a significant role in the pathogenesis of age-related LUT disorders and may explain their increasing prevalence. This systematic review identifies potential markers of disease progression and treatment opportunities; further research is warranted to evaluate these markers and the mechanisms by which these changes may lead to age-related LUT disorders.

참고문헌 (58)

  1. Coyne KS, "The prevalence of lower urinary tract symptoms (LUTS)in the USA, the UK and sweden: results from the epidemiology of LUTS (EpiLUTS) study", BJU Int, 104, pp.352~360 (2009)
  2. Irwin DE, "Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries:Results of the EPIC study", Eur Urol, 50, pp.1306~1305 (2006)
  3. Zhang AY, "Prevalence, burden, and treatment of lower urinary tract symptoms in men aged 50 and older: a systematic review of the literature", SAGE Open Nurs, 4, pp.2377960818811773~ (2018)
  4. Birder LA, "Is there a role for oxidative stress and mitochondrial dysfunction in age-associated bladder disorders", Ci Ji Yi Xue Za Zhi, 32, pp.223~226 (2020)
  5. Vahabi B, "Can we define and characterize the aging lower urinary tract?-ICI-RS 2015", Neurourol Urodyn, 36, pp.854~858 (2017)
  6. Fathollahi A, "Melatonin and its role in lower urinary tract function : an article review", Curr Urol, 8, pp.113~118 (2015)
  7. Birder LA, "Aging increases the expression of vasopressin receptors in both the kidney and urinary bladder", Neurourol Urodyn, 38, pp.393~397 (2019)
  8. Kudryavtseva AV, "Mitochondrial dysfunction and oxidative stress in aging and cancer", Oncotarget, 7, pp.44879~44905 (2016)
  9. Moher D, "Preferred reporting items for systematic reviews and meta-analyses : the PRISMA statement", BMJ, 339, pp.b2535~ (2009)
  10. Moher D, "Preferred reporting items for systematic review and metaanalysis protocols(PRISMA-P)2015 statement", Syst Rev, 4, pp.1~ (2015)
  11. Page MJ, "Tools for assessing risk of reporting biases in studies and syntheses of studies : a systematic review", BMJ Open, 8, pp.e019703~ (2018)
  12. (2022)[URL]
  13. Wei D, "The use of GRADE approach in systematic reviews of animal studies", J Evid Based Med, 9, pp.98~104 (2016)
  14. Aikawa K, "Effect of age on hydrogen peroxide mediated contraction damage in the male rat bladder", J Urol, 170, pp.2082~2085 (2003)
  15. Kirpatovsky VI, "Role of oxidative stress and mitochondria in onset of urinary bladder dysfunction under acute urine retention", Biochemistry(Mosc), 78, pp.542~548 (2013)
  16. Lin WY, "Oxidative stress biomarkers in urine and plasma of rabbits with partial bladder outlet obstruction", BJU Int, 107, pp.1839~1843 (2011)
  17. Nomiya M, "The effect of atherosclerosis-induced chronic bladder ischemia on bladder function in the rat", Neurourol Urodyn, 31, pp.195~200 (2012)
  18. Radu F, "The effect of in vitro ischemia", reperfusion on contraction, free fatty acid content, phospholipid content, and malondialdehyde levels of the rabbit urinary bladder, 2011, pp.346, 179~186
  19. Sezginer EK, "Effects of varying degrees of partial bladder outlet obstruction on urinary bladder function of rats : a novel link to inflammation, oxidative stress and hypoxia", Low Urin Tract Symptoms, 11, pp.O193~O201 (2019)
  20. Su N, "Quantitative proteomic analysis of differentially expressed proteins and downstream signaling pathways in chronic bladder ischemia", J Urol, 195, pp.515~523 (2016)
  21. Vital P, "Oxidative stress promotes benign prostatic hyperplasia", Prostate, 76, pp.58~67 (2016)
  22. Witthaus MW, "Bladder oxidative stress in sleep apnea contributes to detrusor instability and nocturia", J Urol, 193, pp.1692~1699 (2015)
  23. Yang JH, "Mitochondrial stress and activation of PI3K and akt survival pathway in bladder ischemia", Res Rep Urol, 9, pp.93~100 (2017)
  24. Yuan X, "Role of nitric oxide synthase in bladder pathologic remodeling and dysfunction resulting from partial outlet obstruction", Urology, 77, pp.1008.e1~1008.e8 (2011)
  25. Zhang Q, "Effects of ischemia and oxidative stress on bladder purinoceptors expression", Urology, 84, pp.1249.e1~1249.e7 (2014)
  26. Zuohui Zhao, "Progressive changes in detrusor function and micturition patterns with chroinc bladder ischemia", Investigative and Clinical Urology, 57(4), pp.249~259 (2016), 대한비뇨의학회[DOI]
  27. Antunes-Lopes T, "The impact of chronic pelvic ischemia on LUTS and urinary levels of neuroinflammatory, inflammatory, and oxidative stress markers in elderly men: a case-control study", Urology, 123, pp.230~234 (2019)
  28. Averbeck MA, "Oxidative stress in the bladder of men with LUTS undergoing open prostatectomy : a pilot study", Int Braz J Urol, 44, pp.1182~1193 (2018)
  29. Azadzoi KM, "Human bladder smooth muscle cell damage in disturbed oxygen tension", Urology, 78, pp.967.e9~967.e15 (2011)
  30. Ener K, "Evaluation of oxidative stress status and antioxidant capacity in patients with painful bladder syndrome", interstitial cystitis : preliminary results of a randomised study, 2015, pp.47, 1297~1302
  31. Guzel S, "Association of pb, cd, and se concentrations and oxidative damage-related markers in different grades of prostate carcinoma", Biol Trace Elem Res, 145, pp.23~32 (2012)
  32. Keske M, "Relationship between oxidative stress and detrussor overactivity : a case control study", Urol J, 16, pp.371~374 (2019)
  33. Merendino RA, "Malondialdehyde in benign prostate hypertrophy : a useful marker", Mediators Inflamm, 12, pp.127~128 (2003)
  34. Ren H, "The effects of ROS in prostatic stromal cells under hypoxic environment", Aging Male, 18, pp.84~88 (2015)
  35. Levin RM, "Oxidative stress and lower urinary tract dysfunctions primarily found in women", Urol Sci, 21, pp.8~18 (2010)
  36. Andersson KE, "Oxidative stress and its possible relation to lower urinary tract functional pathology", BJU Int, 121, pp.527~533 (2018)
  37. Speich JE, "Are oxidative stress and ischemia significant causes of bladder damage leading to lower urinary tract dysfunction? Report from the ICI-RS 2019", Neurourol Urodyn, 39(Suppl 3), pp.S16~S22 (2020)
  38. Liguori I, "Oxidative stress, aging, and diseases", Clin Interv Aging, 13, pp.757~772 (2018)
  39. Miyata Y, "A review of oxidative stress and urinary dysfunction caused by bladder outlet obstruction and treatments using antioxidants", Antioxidants(Basel), 8, pp.132~ (2019)
  40. Del Rio D, "A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress", Nutr Metab Cardiovasc Dis, 15, pp.316~328 (2005)
  41. Cooke MS, "Oxidative DNA damage:mechanisms, mutation, and disease", FASEB J, 17, pp.1195~1214 (2003)
  42. Cherian DA, "Malondialdehyde as a marker of oxidative stress in periodontitis patients", J Pharm Bioallied Sci, 11(Suppl 2), pp.S297~S300 (2019)
  43. Valavanidis A, "8-hydroxy-2’ -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis", J Environ Sci Health C Environ Carcinog Ecotoxicol Rev, 27, pp.120~139 (2009)
  44. Coverdale JPC, "Ischemia-modified albumin : crosstalk between fatty acid and cobalt binding", Prostaglandins Leukot Essent Fatty Acids, 135, pp.147~157 (2018)
  45. Xiao L, "Using advanced oxidation protein products and ischaemia-modified albumin to monitor oxidative stress levels in patients with drug-induced liver injury", Scientific Reports, 10, pp.18128~ (2020)
  46. Jomova K, "Advances in metal-induced oxidative stress and human disease", Toxicology, 283, pp.65~87 (2011)
  47. Ercal N, "Toxic metals and oxidative stress part I : mechanisms involved in metal-induced oxidative damage", Curr Top Med Chem, 1, pp.529~539 (2001)
  48. Li HS, "HIF-1α protects against oxidative stress by directly targeting mitochondria", Redox Biol, 25, pp.101109~ (2019)
  49. Schiffrin EL, "Oxidative stress, nitric oxide synthase, and superoxide dismutase: A matter of imbalance underlies endothelial dysfunction in the human coronary circulation", Hypertension, 51, pp.31~32 (2008)
  50. Bickel M, "The role of interleukin-8 in inflammation and mechanisms of regulation", J Periodontol, 64(5 Suppl), pp.456~460 (1993)
  51. Lingappan K, "NF-κB in oxidative stress", Curr Opin Toxicol, 7, pp.81~86 (2018)
  52. Verhasselt V, "Oxidative stress up-regulates IL-8 and TNF-alpha synthesis by human dendritic cells", Eur J Immunol, 28, pp.3886~3890 (1998)
  53. Emin O, "Total antioxidant status and oxidative stress and their relationship to total IgE levels and eosinophil counts in children with allergic rhinitis", J Investig Allergol Clin Immunol, 22, pp.188~192 (2012)
  54. Cottone S, "Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension", Am J Hypertens, 19, pp.313~318 (2006)
  55. Hussain T, "Oxidative stress and inflammation : what polyphenols can do for us", Oxid Med Cell Longev, 2016, pp.7432797~ (2016)
  56. Gold R, "Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis", N Engl J Med, 367, pp.1098~1107 (2012)
  57. Irwin DE, "Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction", BJU Int, 108, pp.1132~1138 (2011)
  58. Birder LA, "A uro-protective agent with restorative actions on urethral and striated muscle morphology", World J Urol, 39, pp.2685~2690 (2021)

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