Correlation Between Nitric Oxide and Urodynamics in Men With Bladder Outlet Obstruction
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: To investigate the correlation between nitric oxide (NO) and urodynamics in men with bladder outlet obstruction (BOO) by analyzing nitric oxide synthase (NOS) in the urothelium. Methods: We prospectively enrolled 25 men who planned to undergo surgical treatment for benign prostatic obstruction and identified as BOO in the preoperative urodynamics. Bladder tissue was taken during surgical prostate resection. Expressions of endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS (nNOS) in the urothelium were analyzed, and their correlation with urodynamic parameters was also assessed in all patients. We also compared the expressions of eNOS, iNOS, and nNOS between BOO with detrusor underactivity (DU) group and BOO without DU group. Results: In all patients, the level of eNOS positively correlated with maximal flow rate and with maximum cystometric capacity (MCC). The level of iNOS positively correlated with MCC. nNOS levels were positively correlated with detrusor pressure at maximal flow and with bladder contractility index in all patients. The level of eNOS, iNOS, and nNOS did not significantly differ between BOO without DU group and BOO with DU group. Conclusions: This study suggests that NO was correlated with bladder dysfunction in men with BOO. Particularly, nNOS may reflect the change in detrusor function.
Abstract
Purpose: To investigate the correlation between nitric oxide (NO) and urodynamics in men with bladder outlet obstruction (BOO) by analyzing nitric oxide synthase (NOS) in the urothelium. Methods: We prospectively enrolled 25 men who planned to undergo surgical treatment for benign prostatic obstruction and identified as BOO in the preoperative urodynamics. Bladder tissue was taken during surgical prostate resection. Expressions of endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS (nNOS) in the urothelium were analyzed, and their correlation with urodynamic parameters was also assessed in all patients. We also compared the expressions of eNOS, iNOS, and nNOS between BOO with detrusor underactivity (DU) group and BOO without DU group. Results: In all patients, the level of eNOS positively correlated with maximal flow rate and with maximum cystometric capacity (MCC). The level of iNOS positively correlated with MCC. nNOS levels were positively correlated with detrusor pressure at maximal flow and with bladder contractility index in all patients. The level of eNOS, iNOS, and nNOS did not significantly differ between BOO without DU group and BOO with DU group. Conclusions: This study suggests that NO was correlated with bladder dysfunction in men with BOO. Particularly, nNOS may reflect the change in detrusor function.
참고문헌 (23)
- Sutherland RS, "Neuroanatomical changes in the rat bladder after bladder outlet obstruction", Br J Urol, 82, pp.895~901 (1998)
- Nathan Hoag, "Underactive Bladder: Clinical Features, Urodynamic Parameters, and Treatment", International Neurourology Journal, 19(3), pp.185~189 (2015), 대한배뇨장애요실금학회
- Kim M, "Effect of preoperative urodynamic detrusor underactivity on transurethral surgery for benign prostatic hyperplasia : a systematic review and meta-analysis", J Urol, 199, pp.237~244 (2018)
- Niemczyk G, "Pathophysiological effect of bladder outlet obstruction on the urothelium", Ultrastruct Pathol, 42, pp.317~322 (2018)
- Sellers D, "Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium", Naunyn Schmiedebergs Arch Pharmacol, 391, pp.675~694 (2018)
- Kim HS, "Effects of nitric oxide synthases on detrusor overactivity after removal of bladder outlet obstruction in rats", Urol Int, 81, pp.107~112 (2008)
- Yuan X, "Role of nitric oxide synthase in bladder pathologic remodeling and dysfunction resulting from partial outlet obstruction", Urology, 77, pp.1008.e1~1008.e8 (2011)
- Drake MJ, "Fundamentals of urodynamic practice, based on International Continence Society good urodynamic practices recommendations", Neurourol Urodyn, 37, pp.S50~60 (2018)
- Cho KJ, "Changes in adenosine triphosphate and nitric oxide in the urothelium of patients with benign prostatic hyperplasia and detrusor underactivity", J Urol, 198, pp.1392~1396 (2017)
- Birder L, "Urothelial signaling", Physiol Rev, 93, pp.653~680 (2013)
- Birder LA, "Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells", J Neurosci, 22, pp.8063~8070 (2002)
- Sancho M, "Altered neuronal and endothelial nitric oxide synthase expression in the bladder and urethra of cyclophosphamide-treated rats", Nitric Oxide, 39, pp.8~19 (2014)
- Jiang YH, "Urothelial barrier deficits, suburothelial inflammation and altered sensory protein expression in detrusor underactivity", J Urol, 197, pp.197~203 (2017)
- Felsen D, "Inducible nitric oxide synthase promotes pathophysiological consequences of experimental bladder outlet obstruction", J Urol, 169, pp.1569~1572 (2003)
- Pereira ML, "Effects of nitric oxide inhibitors in mice with bladder outlet obstruction", Int Braz J Urol, 43, pp.356~366 (2017)
- Biallosterski BT, "Changes in bladder innervation in a mouse model of Alzheimer’s disease", J Chem Neuroanat, 39, pp.204~210 (2010)
- Hu J, "The effect of chronic bladder outlet obstruction on neuronal nitric oxide synthase expression in the intramural ganglia of the guinea pig bladder", J Urol, 172, pp.1160~1165 (2004)
- Hu J, "Effects of l-arginine and N(G)-nitro-l-arginine methyl ester treatments on expression of neuronal nitric oxide synthase in the guinea-pig bladder after partial bladder outlet obstruction", Neuroscience, 151, pp.680~691 (2008)
- Hannan JL, "Impaired contraction and decreased detrusor innervation in a female rat model of pelvic neuropraxia", Int Urogynecol J, 28, pp.1049~1056 (2017)
- Theobald RJ Jr, "Differing effects of N(G)-monomethyl L-arginine and 7-nitroindazole on detrusor activity", Neurourol Urodyn, 22, pp.62~69 (2003)
- Nishijima S, "Mechanisms underlying the effects of propiverine on bladder activity in rats with pelvic venous congestion and urinary frequency", Biomed Res, 40, pp.145~152 (2019)
- Kim SO, "Effect of detrusor overactivity on the expression of aquaporins and nitric oxide synthase in rat urinary bladder following bladder outlet obstruction", Can Urol Assoc J, 7, pp.E268~74 (2013)
- Osman NI, "Detrusor underactivity and the underactive bladder: a new clinical entity? A review of current terminology, definitions, epidemiology, aetiology, and diagnosis", Eur Urol, 65, pp.389~398 (2014)