The Urobiome and Its Role in Overactive Bladder
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Urine is no longer considered to be sterile. After the existence of the microbiome was revealed through metagenomic analysis using next-generation sequencing, the relationship between characteristics of the microbiome and diseases have been studied and published in various journals. A microbiome exists in the urinary tract and is associated with urinary tract infection, malignancy of the genitourinary tract, and lower urinary tract symptoms. Based on the urine sampling method, sampling site, culture method, and sex, the characteristics of the microbiome vary. Most of the Lactobacillus species are identified mainly in women, and various other species are identified in men. These microorganisms can cause or prevent various diseases. Variations in the microbiome are seen in those with and without disease, and an asymptomatic status does not indicate the absence of microbes. This microbiome has been implicated in a variety of lower urinary tract symptoms and diseases, in particular, overactive bladder. The microbiome differs between patients with urgency and urge urinary incontinence and healthy individuals. There are many aspects of the microbiome yet to be studied in relation to other lower urinary tract symptoms.
Abstract
Urine is no longer considered to be sterile. After the existence of the microbiome was revealed through metagenomic analysis using next-generation sequencing, the relationship between characteristics of the microbiome and diseases have been studied and published in various journals. A microbiome exists in the urinary tract and is associated with urinary tract infection, malignancy of the genitourinary tract, and lower urinary tract symptoms. Based on the urine sampling method, sampling site, culture method, and sex, the characteristics of the microbiome vary. Most of the Lactobacillus species are identified mainly in women, and various other species are identified in men. These microorganisms can cause or prevent various diseases. Variations in the microbiome are seen in those with and without disease, and an asymptomatic status does not indicate the absence of microbes. This microbiome has been implicated in a variety of lower urinary tract symptoms and diseases, in particular, overactive bladder. The microbiome differs between patients with urgency and urge urinary incontinence and healthy individuals. There are many aspects of the microbiome yet to be studied in relation to other lower urinary tract symptoms.
참고문헌 (81)
- Marchesi JR, "The vocabulary of microbiome research : a proposal", Microbiome, 3, pp.31~ (2015)
- 박상태, "Trends in Next-Generation Sequencing and a New Era for Whole Genome Sequencing", International Neurourology Journal, 20, pp.76~83 (2016), 대한배뇨장애요실금학회
- Drake MJ, "The urinary microbiome and its contribution to lower urinary tract symptoms; ICI-RS 2015", Neurourol Urodyn, 36, pp.850~853 (2017)
- Aragón IM, "The urinary tract microbiome in health and disease", Eur Urol Focus, 4, pp.128~138 (2018)
- Kogan MI, "Human urine is not sterile-shift of paradigm", Urol Int, 94, pp.445~452 (2015)
- 김아람, "What is the Cause of Recurrent Urinary Tract Infection? Contemporary Microscopic Concepts of Pathophysiology", International Neurourology Journal, 25(3), pp.192~201 (2021), 대한배뇨장애요실금학회[DOI]
- 김명수, "The Urinary Tract Microbiome in Male Genitourinary Diseases: Focusing on Benign Prostate Hyperplasia and Lower Urinary Tract Symptoms", International Neurourology Journal, 25(1), pp.3~11 (2021), 대한배뇨장애요실금학회[DOI]
- Drake MJ, "Do we need a new definition of the overactive bladder syndrome? ICI-RS 2013", Neurourol Urodyn, 33, pp.622~624 (2014)
- Tariq F. Al-Shaiji, "Relationship between Body Mass Index and Overactive Bladder in Women and Correlations with Urodynamic Evaluation", International Neurourology Journal, 16(3), pp.126~131 (2012), 대한배뇨장애요실금학회[DOI]
- Hakki Uzum, "Association of Insulin Resistance with Overactive Bladder in Female Patients", International Neurourology Journal, 16(4), pp.181~186 (2012), 대한배뇨장애요실금학회[DOI]
- Peyronnet B, "A comprehensive review of overactive bladder pathophysiology : on the way to tailored treatment", Eur Urol, 75, pp.988~1000 (2019)
- Rachel Shoemaker, "Urobiome: An outlook on the metagenome of urological diseases", Investigative and Clinical Urology, 62(6), pp.611~622 (2021), 대한비뇨의학회[DOI]
- Wolfe AJ, ""Sterile urine"and the presence of bacteria", Eur Urol, 68, pp.173~174 (2015)
- Fouts DE, "Integrated next-generation sequencing of 16S rDNA and metaproteomics differentiate the healthy urine microbiome from asymptomatic bacteriuria in neuropathic bladder associated with spinal cord injury", J Transl Med, 10, pp.174~ (2012)
- Price TK, "The clinical urine culture : enhanced techniques improve detection of clinically relevant microorganisms", J Clin Microbiol, 54, pp.1216~1222 (2016)
- Perez-Carrasco V, "Urinary microbiome : yin and yang of the urinary tract", Front Cell Infect Microbiol, 11, pp.617002~ (2021)
- Hans G. Pohl, "The Urine Microbiome of Healthy Men and Women Differs by Urine Collection Method", International Neurourology Journal, 24(1), pp.41~51 (2020), 대한배뇨장애요실금학회[DOI]
- Wolfe AJ, "Urobiome updates : advances in urinary microbiome research", Nat Rev Urol, 16, pp.73~74 (2019)
- Ozer MS, "Urinary microbiota; which non-ınvasive urine collection method should we use", Int J Clin Pract, 75, pp.e14193~ (2021)
- Kramer H, "Diversity of the midstream urine microbiome in adults with chronic kidney disease", Int Urol Nephrol, 50, pp.1123~1130 (2018)
- Koedooder R, "Identification and evaluation of the microbiome in the female and male reproductive tracts", Hum Reprod Update, 25, pp.298~325 (2019)
- Ghemrawi M, "The genital microbiome and its potential for detecting sexual assault", Forensic Sci Int Genet, 51, pp.102432~ (2021)
- 이승주, "Commentary on “The Urine Microbiome of Healthy Men and Women Differs by Urine Collection Method”", International Neurourology Journal, 24(2), pp.182~184 (2020), 대한배뇨장애요실금학회[DOI]
- Curtiss N, "Age, menopausal status and the bladder microbiome", Eur J Obstet Gynecol Reprod Biol, 228, pp.126~129 (2018)
- Pearce MM, "The female urinary microbiome in urgency urinary incontinence", Am J Obstet Gynecol, 213, pp.347.e1~347.e11 (2015)
- Thomas-White KJ, "Urinary microbes and postoperative urinary tract infection risk in urogynecologic surgical patients", Int Urogynecol J, 29, pp.1797~1805 (2018)
- Liu F, "Characterization of the urinary microbiota of elderly women and the effects of type 2 diabetes and urinary tract infections on the microbiota", Oncotarget, 8, pp.100678~100690 (2017)
- Komesu YM, "The urinary microbiome in women with mixed urinary incontinence compared to similarly aged controls", Int Urogynecol J, 29, pp.1785~1795 (2018)
- Pearce MM, "The female urinary microbiome : a comparison of women with and without urgency urinary incontinence", mBio, 5, pp.e01283-14~ (2014)
- Thomas-White KJ, "Incontinence medication response relates to the female urinary microbiota", Int Urogynecol J, 27, pp.723~733 (2016)
- Siddiqui H, "Alterations of microbiota in urine from women with interstitial cystitis", BMC Microbiol, 12, pp.205~ (2012)
- Neugent ML, "Advances in understanding the human urinary microbiome and its potential role in urinary tract infection", mBio, 11, pp.e00218~e00220 (2020)
- Price TK, "Bladder bacterial diversity differs in continent and incontinent women : a cross-sectional study", Am J Obstet Gynecol, 223, pp.729.e1~729.e10 (2020)
- Okamoto T, "Altered gut microbiome associated with overactive bladder and daily urinary urgency", World J Urol, 39, pp.847~853 (2021)
- Modena BD, "Changes in urinary microbiome populations correlate in kidney transplants with interstitial fibrosis and tubular atrophy documented in early surveillance biopsies", Am J Transplant, 17, pp.712~723 (2017)
- Diop K, "Exhaustive repertoire of human vaginal microbiota", Hum Microbiome J, 11, pp.100051~ (2019)
- Morand A, "Human bacterial repertoire of the urinary tract : a potential paradigm shift", J Clin Microbiol, 5, pp.e00675-18~ (2019)
- Antunes-Lopes T, "Urinary biomarkers in overactive bladder : revisiting the evidence in 2019", Eur Urol Focus, 5, pp.329~336 (2019)
- 서윤석, "Potential Biomarkers for Diagnosis of Overactive Bladder Patients: Urinary Nerve Growth Factor, Prostaglandin E2, and Adenosine Triphosphate", International Neurourology Journal, 21(3), pp.171~177 (2017), 대한배뇨장애요실금학회
- 서윤석, "Urinary Nerve Growth Factor as a Potential Biomarker of Treatment Outcomes in Overactive Bladder Patients", International Neurourology Journal, 21(4), pp.270~281 (2017), 대한배뇨장애요실금학회
- Sapre N, "A urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance", Br J Cancer, 114, pp.454~462 (2016)
- 윤석중, "Urinary MicroRNAs of Prostate Cancer: Virus-Encoded hsv1-miRH18 and hsv2-miR-H9-5p Could Be Valuable Diagnostic Markers", International Neurourology Journal, 19(2), pp.74~84 (2015), 대한배뇨장애요실금학회
- Monastyrskaya K, "Urinary biomarkers for bladder outlet obstruction", Curr Bladder Dysfunct Rep, 12, pp.129~137 (2017)
- Nienhouse V, "Interplay between bladder microbiota and urinary antimicrobial peptides : mechanisms for human urinary tract infection risk and symptom severity", PLoS One, 9, pp.e114185~ (2014)
- Kim JC, "Changes of urinary nerve growth factor and prostaglandins in male patients with overactive bladder symptom", Int J Urol, 12, pp.875~880 (2005)
- Chuang YC, "Intravesical botulinum toxin A administration inhibits COX-2 and EP4 expression and suppresses bladder hyperactivity in cyclophosphamide-induced cystitis in rats", Eur Urol, 56, pp.159~166 (2009)
- Ford AP, "In pursuit of P2X3 antagonists : novel therapeutics for chronic pain and afferent sensitization", Purinergic Signal, 8, pp.3~26 (2012)
- Harvey RA, "The contractile potency of adenosine triphosphate and ecto-adenosine triphosphatase activity in guinea pig detrusor and detrusor from patients with a stable, unstable or obstructed bladder", J Urol, 168, pp.1235~1239 (2002)
- Qu HC, "Association between polymorphism of β3-adrenoceptor gene and overactive bladder : a metaanalysis", Genet Mol Res, 14, pp.2495~2501 (2015)
- Curtiss N, "A case controlled study examining the bladder microbiome in women with Overactive Bladder(OAB)and healthy controls", Eur J Obstet Gynecol Reprod Biol, 214, pp.31~35 (2017)
- Burnett LA, "Recurrent urinary tract infection : association of clinical profiles with urobiome composition in women", Neurourol Urodyn, 40, pp.1479~1489 (2021)
- Holland B, "The effect of the urinary and faecal microbiota on lower urinary tract symptoms measured by the International Prostate Symptom Score : analysis utilising next-generation sequencing", BJU Int, 125, pp.905~910 (2020)
- Angelini KJ, "An integrative review of current research on the role of the female urinary microbiota in overactive bladder symptoms", Urol Nurs, 37, pp.94~100 (2017)
- Govender Y, "The current evidence on the association between the urinary microbiome and urinary incontinence in women", Front Cell Infect Microbiol, 9, pp.133~ (2019)
- Brubaker L, "Microbiota in 2016 : associating infection and incontinence with the female urinary microbiota", Nat Rev Urol, 14, pp.72~74 (2017)
- Karstens L, "Does the urinary microbiome play a role in urgency urinary incontinence and its severity", Front Cell Infect Microbiol, 6, pp.78~ (2016)
- Ke QS, "Recurrent urinary tract infection in women and overactive bladder-is there a relationship", Tzu Chi Med J, 33, pp.13~21 (2021)
- Richter HE, "Association between the urogenital microbiome and surgical treatment response in women undergoing midurethral sling operation for mixed urinary incontinence", Am J Obstet Gynecol, 226, pp.93.e1~93.e15 (2022)
- Siddiqui H, "Pathogens in urine from a female patient with overactive bladder syndrome detected by culture-independent high throughput sequencing : a case report", Open Microbiol J, 8, pp.148~153 (2014)
- Thomas-White K, "Vaginal estrogen therapy is associated with increased Lactobacillus in the urine of postmenopausal women with overactive bladder symptoms", Am J Obstet Gynecol, 223, pp.727.e1~727.e11 (2020)
- Abbasian B, "Potential role of extracellular atp released by bacteria in bladder infection and contractility", mSphere, 4, pp.e00439-19~ (2019)
- Chen Z, "The urinary microbiome in patients with refractory urge incontinence and recurrent urinary tract infection", Int Urogynecol J, 29, pp.1775~1782 (2018)
- Thomas-White K, "Culturing of female bladder bacteria reveals an interconnected urogenital microbiota", Nat Commun, 9, pp.1557~ (2018)
- Bajic P, "Male bladder microbiome relates to lower urinary tract symptoms", Eur Urol Focus, 6, pp.376~382 (2020)
- Siddiqui H, "Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons", BMC Microbiol, 11, pp.244~ (2011)
- Wolfe AJ, "Evidence of uncultivated bacteria in the adult female bladder", J Clin Microbiol, 50, pp.1376~1383 (2012)
- Lewis DA, "The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults", Front Cell Infect Microbiol, 3, pp.41~ (2013)
- Hilt EE, "Urine is not sterile : use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder", J Clin Microbiol, 52, pp.871~876 (2014)
- Wu P, "Urinary microbiome and psychological factors in women with overactive bladder", Front Cell Infect Microbiol, 7, pp.488~ (2017)
- Gottschick C, "The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment", Microbiome, 5, pp.99~ (2017)
- Abernethy MG, "Urinary microbiome and cytokine levels in women with interstitial cystitis", Obstet Gynecol, 129, pp.500~506 (2017)
- Wang H, "Breast tissue, oral and urinary microbiomes in breast cancer", Oncotarget, 8, pp.88122~88138 (2017)
- Rani A, "Urinary microbiome of kidney transplant patients reveals dysbiosis with potential for antibiotic resistance", Transl Res, 181, pp.59~70 (2017)
- Meriwether KV, "The vaginal and urinary microbiomes in premenopausal women with interstitial cystitis", bladder pain syndrome as compared to unaffected controls : a pilot cross-sectional study, 2019, pp.9, 92~
- Bresler L, "Female lower urinary tract microbiota do not associate with IC", PBS symptoms : a case-controlled study, 2019, pp.30, 1835~1842
- Liu F, "Characteristics of the urinary microbiome in kidney stone patients with hypertension", J Transl Med, 18, pp.130~ (2020)
- Nelson DE, "Bacterial communities of the coronal sulcus and distal urethra of adolescent males", PLoS One, 7, pp.e36298~ (2012)
- Wu P, "Profiling the urinary microbiota in male patients with bladder cancer in china", Front Cell Infect Microbiol, 8, pp.167~ (2018)
- Bučević Popović V, "The urinary microbiome associated with bladder cancer", Sci Rep, 8, pp.12157~ (2018)
- Kassiri B, "A prospective study of the urinary and gastrointestinal microbiome in prepubertal males", Urology, 131, pp.204~210 (2019)
- Xie J, "Profiling the urinary microbiome in men with calcium-based kidney stones", BMC Microbiol, 20, pp.41~ (2020)
