수학적 모델링을 이용한 골조직 세포 네트워크에서 Osteal Macrophage와 골세포의 역할 예측
Predicting the Role of Osteal Macrophages and Osteocytes in Bone Tissue Network Using a Mathematical Modeling
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The aim of this study was to investigate the role of osteal macrophages (osteomac) and osteocytes in bone remodeling using a mathematical model. We constructed the bone system with pre-osteoblasts, osteoclasts, osteocytes, and osteomac. Each link of the parameters and ordinary differential equations followed the Graham's model in 2013 except for the parameters of osteomac signaling and osteocytes signaling to link preosteoblasts and osteoblasts. We simulated the changes in each cell and bone volume according to the changes in the parameters of osteomac signaling and osteocytes signaling. The results showed bone volume was unstable and decreased gradually when the effectiveness of osteocytes and osteomac dropped below a certain level. When the parameters of osteomac signaling and osteocytes signaling to link preosteoblasts and osteoblasts had a value less than 1, bone volume increased with the increase in the parameter of osteomac signaling to link preosteoblasts and osteoblasts. Moreover, although the parameter of osteocytes signaling to link preosteoblasts and osteoblasts, increased in case of a small parameter of osteomac signaling, bone volulme decreased. If the parameters of osteomac signaling to link preosteoblasts and osteoblasts were over a certain level, bone volume was positively maintained, despite the parameter of osteocyte signaling to link preosteoblasts and osteoblasts. We suggested the osteomac may affect bone remodeling and may play an important role in bone cell network.
Abstract
The aim of this study was to investigate the role of osteal macrophages (osteomac) and osteocytes in bone remodeling using a mathematical model. We constructed the bone system with pre-osteoblasts, osteoclasts, osteocytes, and osteomac. Each link of the parameters and ordinary differential equations followed the Graham's model in 2013 except for the parameters of osteomac signaling and osteocytes signaling to link preosteoblasts and osteoblasts. We simulated the changes in each cell and bone volume according to the changes in the parameters of osteomac signaling and osteocytes signaling. The results showed bone volume was unstable and decreased gradually when the effectiveness of osteocytes and osteomac dropped below a certain level. When the parameters of osteomac signaling and osteocytes signaling to link preosteoblasts and osteoblasts had a value less than 1, bone volume increased with the increase in the parameter of osteomac signaling to link preosteoblasts and osteoblasts. Moreover, although the parameter of osteocytes signaling to link preosteoblasts and osteoblasts, increased in case of a small parameter of osteomac signaling, bone volulme decreased. If the parameters of osteomac signaling to link preosteoblasts and osteoblasts were over a certain level, bone volume was positively maintained, despite the parameter of osteocyte signaling to link preosteoblasts and osteoblasts. We suggested the osteomac may affect bone remodeling and may play an important role in bone cell network.
참고문헌 (21)
- Breitling R, "What is systems biology?", Front Physiol, 1, pp.9~ (2010)
- Kitano H, "Systems biology: a brief overview", Science, 295, pp.1662~1664 (2002)[DOI]
- Hsu YH, "Variation in genes involved in the RANKL", RANK, Hum Genet, pp.2006, 118[DOI]
- Lamora A, "TGF-<TEX>${\beta}$<", TEX> signaling in bone remodeling and osteosarcoma progression, 2016, pp.5, E96~
- Poon B, "Bone morphogenetic protein-2 and bone therapy: successes and pitfalls", J Pharm Pharmacol, 68, pp.139~147 (2016)[DOI]
- Karner CM, "Wnt signaling and cellular metabolism in osteoblasts", Cell Mol Life Sci, 74, pp.1649~1657 (2017)[DOI]
- Zhao B, "TNF and bone remodeling", Curr Osteoporos Rep, 15, pp.126~134 (2017)[DOI]
- Ruscitti P, "The role of IL-1<TEX>${\beta}$<", TEX> in the bone loss during rheumatic diseases, 2015, pp.2015, 782382~
- Prideaux M, "Osteocytes: the master cells in bone remodelling", Curr Opin Pharmacol, 28, pp.24~30 (2016)[DOI]
- Miron RJ, "OsteoMacs: key players around bone biomaterials", Biomaterials, 82, pp.1~19 (2016)[DOI]
- Graham JM, "The role of osteocytes in targeted bone remodeling: a mathematical model", PLoS One, 8, pp.e63884~ (2013)[DOI]
- Raggatt LJ, "Cellular and molecular mechanisms of bone remodeling", J Biol Chem, 285, pp.25103~25108 (2010)[DOI]
- Teitelbaum SL, "Osteoclasts, macrophage, and the molecular mechanisms of bone resorption", J Leukoc Biol, 61, pp.381~388 (1997)[DOI]
- Komarova SV, "Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling", Bone, 33, pp.206~215 (2003)[DOI]
- Ayati BP, "A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease", Biol Direct, 5, pp.28~ (2010)[DOI]
- Lemaire V, "Modeling the interactions between osteoblast and osteoclast activities in bone remodeling", J Theor Biol, 229, pp.293~309 (2004)[DOI]
- Pivonka P, "Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling", J Theor Biol, 262, pp.306~316 (2010)[DOI]
- Sun X, "Cytokine combination therapy prediction for bone remodeling in tissue engineering based on the intracellular signaling pathway", Biomaterials, 33, pp.8265~8276 (2012)[DOI]
- Sabokbar A, "Human arthroplasty derived macrophage differentiate into osteoclast bone resorbing cells", Ann Rheum Dis, 56, pp.414~420 (1997)[DOI]
- Fujikawa Y, "Human osteoclast formation and bone resorption by monocytes and synovial macrophages in rheumatoid arthritis", Ann Rheum Dis, 55, pp.816~822 (1996)[DOI]
- Chang MK, "Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo", J Immunol, 181, pp.1232~1244 (2008)[DOI]