본문 바로가기
KERD
논문KCI 등재

A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities

0

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류한의학

초록

Portulaca oleracea L. (PO) or Purslane is an annual grassy plant that is distributed in many parts of the world, especially the tropical and subtropical areas. PO has some pharmacological properties such as analgesic, antibacterial, skeletal muscle-relaxant, wound-healing, anti- inflammatory and a radical scavenger. This review article is focused on the anti-inflammatory, immuno-modulatory, anti-oxidant and anti-tumor activities of the PO. Anti-inflammatory, immuno-modulatory, anti-oxidant and Anti-tumor effects of PO were searched using various databases until the end of August 2018. The online literature was searched using PubMed, Science Direct, Scopus, Google Scholar and Web of Science. Our review showed that PO exerts its effects through anti-inflammatory properties and balancing the adaptive and innate immune system depending on situations. PO acts as immune-modulator and anti-oxidant agent in both inflammatory states by the dominance of Th2 response such as asthma, cancer and atopic dermatitis and evoked Th1 disorders including hepatitis and multiple sclerosis.

Abstract

Portulaca oleracea L. (PO) or Purslane is an annual grassy plant that is distributed in many parts of the world, especially the tropical and subtropical areas. PO has some pharmacological properties such as analgesic, antibacterial, skeletal muscle-relaxant, wound-healing, anti- inflammatory and a radical scavenger. This review article is focused on the anti-inflammatory, immuno-modulatory, anti-oxidant and anti-tumor activities of the PO. Anti-inflammatory, immuno-modulatory, anti-oxidant and Anti-tumor effects of PO were searched using various databases until the end of August 2018. The online literature was searched using PubMed, Science Direct, Scopus, Google Scholar and Web of Science. Our review showed that PO exerts its effects through anti-inflammatory properties and balancing the adaptive and innate immune system depending on situations. PO acts as immune-modulator and anti-oxidant agent in both inflammatory states by the dominance of Th2 response such as asthma, cancer and atopic dermatitis and evoked Th1 disorders including hepatitis and multiple sclerosis.

참고문헌 (53)

  1. Costa JFO, "Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii", Fitoterapia, 78(7), pp.510~514 (2007)
  2. Askari VR, "The influence of hydro- ethanolic extract of Portulaca oleracea L. on Th1", Th2 balance in isolated human lymphocytes, 2016, pp.194, 1112~1121
  3. Noorbakhshnia M, "Portulaca oleracea L. prevents lipopolysaccharide-induced passive avoidance learning and memory and TNF impairments in hippocampus of rat", Physiol. Behav, 169, pp.69~73 (2017)
  4. Iranshahy M, "A review of traditional uses, phytochemistry, and pharmacology of Portulaca oleracea L", J. Ethnopharmacol, 205, pp.158~172 (2017)
  5. Wu B, "New CuCl 2-induced glucoside esters and other constituents from Portucala oleracea", Carbohydr. Res, 351, pp.68~73 (2012)
  6. Bai Y, "Anti-diabetic effect of Portulaca oleracea L. Polysaccharideandits mechanism in diabetic rats", Int. J. Mol. Sci, 17(8), pp.1201~ (2016)
  7. Lee AS, "Anti-TNF-alpha activity of Portulaca oleracea in vascular endothelial cells", Int. J. Mol. Sci, 13(5), pp.5628~5644 (2012)
  8. Chan K, "The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak", J. Ethnopharmacol, 73(3), pp.445~451 (2000)
  9. Shakeri F, "A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism (s) and potency", J. Ethnopharmacol, 175, pp.528~548 (2015)
  10. Lim Y, "Antioxidant properties of different cultivars of Portulaca oleracea", Food Chem, 103(3), pp.734~740 (2007)
  11. Dkhil MA, "Antioxidant effect of purslane (Portulaca oleracea) and its mechanism of action", J. Med. Plant. Res, 5(9), pp.1589~1593 (2011)
  12. Yue T, "The Effects of Portulaca oleracea on Hypoxia-Induced Pulmonary Edema in Mice", High Alt. Med. Biol, 16(1), pp.43~51 (2015)
  13. Gai Guo LY, "Antioxidant and Antiproliferative Activities of Purslane Seed Oil", J. Hypertens, 5(2) (2016)
  14. Li L-L, "Effect of Extraction Reagents on the Content of Phenolics and Antioxidant Activity of Portulaca oleracea L", XXVII International Horticultural Congress-IHC2006: International Symposium on Plants as Food and Medicine: The Utilization, pp.765~ (2006)
  15. Zhou Y-X, "Portulaca oleracea L.: a review of phytochemistry and pharmacological effects", BioMed Res. Int (2015)
  16. Xu X, "Determination of flavonoids in Portulaca oleracea L. by capillary electrophoresis with electrochemical detection", J. Pharm. Biomed. Anal, 41(2), pp.493~499 (2006)
  17. Zhu H, "Analysis of Flavonoids in Portulaca oleracea L. by UV– Vis Spectrophotometry with Comparative Study on Different Extraction Technologies", Food Anal. Methods, 3(2), pp.90~97 (2010)
  18. Yan J, "Homoisoflavonoids from the medicinal plant Portulaca oleracea", Phytochemistry, 80, pp.37~41 (2012)
  19. Yue ME, "Simultaneous determination of noradrenaline and dopamine in Portulaca oleracea L. by capillary zone electrophoresis", J. Sep. Sci, 28(4), pp.360~364 (2005)
  20. Chen J, "Determination of noradrenaline and dopamine in Chinese herbal extracts from Portulaca oleracea L. by high-performance liquid chromatography", J. Chromatogr. A, 1003(1- 2), pp.127~132 (2003)
  21. Xiang L, "Alkaloids from Portulaca oleracea L", Phytochemistry, 66(21), pp.2595~2601 (2005)
  22. Tian JL, "Two new alkaloids from Portulaca oleracea and their cytotoxic activities", J. Asian Nat. Prod. Res, 16(3), pp.259~264 (2014)
  23. Liang X, "Rapid determination of eight bioactive alkaloids in Portulaca oleracea L. by the optimal microwave extraction combined with positive-negative conversion multiple reaction monitor (+", -MRM) technology, 2014, pp.120, 167~172
  24. Aljeboori KH, "Study of pathological, effects of crude extract of Portulaca olercea L. in the albino mice organs", Int. J. Tech. Res. Appl, 2(1), pp.29~32 (2014)
  25. Sakai N, "Portuloside A, a monoterpene glucoside, from Portulaca oleracea", Phytochemistry, 42(6), pp.1625~1628 (1996)
  26. 서영완, "A New Monoterpene Glucoside from Portulaca oleracea", Bulletin of the Korean Chemical Society, 24(10), pp.1475~1477 (2003), 대한화학회
  27. Elkhayat ES, "Portulene, a new diterpene from Portulaca oleracea L", J. Asian Nat. Prod. Res, 10(11-12), pp.1039~1043 (2008)
  28. Xin H-L, "Two Novel Triterpenoids from Portulaca oleracea L", Helv. Chim. Acta, 91(11), pp.2075~2080 (2008)
  29. Mohamed AI, "Chemical composition of purslane (Portulaca oleracea)", Plant Foods Hum. Nutr, 45(1), pp.1~9 (1994)
  30. Uddin MK, "Purslane weed(Portulaca oleracea) : a prospective plant source of nutrition, omega-3 fatty acid, and antioxidant attributes", Scientific World Journal, 2014, pp.951019~ (2014)
  31. Cheng Z, "LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration", Nat. Prod. Res, 26(23), pp.2247~2250 (2012)
  32. Palaniswamy UR, "Stage of harvest and polyunsaturated essential fatty acid concentrations in purslane (Portulaca oleraceae) leaves", J. Agric. Food Chem, 49(7), pp.3490~3493 (2001)
  33. Esiyok D, "Herbs as a food source in Turkey", Asian Pac. J. Cancer Prev, 5(3), pp.334~339 (2004)
  34. Simopoulos AP, "Purslane: a plant source of omega-3 fatty acids and melatonin", J. Pineal Res, 39(3), pp.331~332 (2005)
  35. Palaniswamy UR, "Effect of nitrate : ammonium nitrogen ratio on oxalate levels of purslane", Trends New Crops New Uses, 11(5), pp.453~455 (2002)
  36. Georgiev YN, "Acidic polysaccharide complexes from purslane, silver linden and lavender stimulate Peyer’s patch immune cells through innate and adaptive mechanisms", Int. J. Biol. Macromol (2017)
  37. Xu L, "A novel alkaloid from Portulaca oleracea L", Nat. Prod. Res, 31(8), pp.902~908 (2017)
  38. 김재현, "Anti-oxidative and Anti-inflammatory Effects of Protulaca Oleracea on the LPS-stimulated AGS Cells", 동의생리병리학회지, 23(2), pp.488~493 (2009), 한의병리학회
  39. Swamy M, "Nitric oxide (no), citrulline-no cycle enzymes, glutamine synthetase and oxidative stress in anoxia (hypobaric hypoxia) and reperfusion in rat brain", Int. J. Med. Sci, 7(3), pp.147~ (2010)
  40. Malek F, "Bronchodilatory effect of Portulaca oleracea in airways of asthmatic patients", J. Ethnopharmacol., 93(1), pp.57~62 (2004)
  41. Mulry KR, "Alternative Strategies in Response to Saline Stress in Two Varieties of Portulaca oleracea (Purslane)", PloS one, 10(9), pp.e0138723~ (2015)
  42. Ahangarpour A, "Effects of Portulaca oleracea ethanolic extract on reproductive system of aging female mice", Int. J. Reprod. BioMed, 14(3), pp.205~ (2016)
  43. Kaveh M, "The Extract of Portulaca oleracea and its Constituent, Alpha Linolenic Acid Affects Serum Oxidant Levels and Inflammatory Cells in Sensitized Rats", Iran. J. Allergy. Asthma Immunol (2017)
  44. Javad Behravan, "Protective Effects of Aqueous and Ethanolic Extracts of Portulaca oleracea L. Aerial Parts on H_2O_2- Induced DNA Damage in Lymphocytes by Comet Assay", Journal of Acupuncture & Meridian Studies, 4(3), pp.193~197 (2011), 사단법인약침학회
  45. Li Y, "Evaluation of antioxidant and immuno-enhancing activities of Purslane polysaccharides in gastric cancer rats", Int. J. Biol. Macromol, 68, pp.113~116 (2014)
  46. Kaveh M, "Modulation of lung inflammation and immune markers in asthmatic rats treated by Portulaca oleracea", Avicenna J. Phytomed, 7(5), pp.409~416 (2017)
  47. Barakat LA, "The antiatherogenic, renal protective and immunomodulatory effects of purslane, pumpkin and flax seeds on hypercholesterolemic rats", N. Am. J. Med. Sci, 3(9), pp.411~417 (2011)
  48. Catap ES, "In vivo nonspecific immunomodulatory and antispasmodic effects of common purslane (Portulaca oleracea Linn.) leaf extracts in ICR mice", J. Ethnopharmacol, 215, pp.191~198 (2018)
  49. Shen H, "Purification and characterization of an antitumor polysaccharide from Portulaca oleracea L", Carbohyd. Polym, 93(2), pp.395~400 (2013)
  50. Farshori NN, "Cytotoxicity Assessments of Portulaca oleracea and Petroselinum sativum Seed Extracts on Human Hepatocellular Carcinoma Cells (HepG2)", Asian Pac. J. Cancer Prev, 15(16), pp.6633~6638 (2014)
  51. YouGuo C, "Evaluation of free radicals scavenging and immunity- modulatory activities of Purslane polysaccharides. Int", J. Biol. Macromol, 45(5), pp.448~452 (2009)
  52. Chen T, "Sulfated modification and cytotoxicity of Portulaca oleracea L. polysaccharides", Glycoconj J, 27(6), pp.635~642 (2010)
  53. Zheng G-Y, "Portulacerebroside A induces apoptosis via activation of the mitochondrial death pathway in human liver cancer HCCLM3 cells", Phytochem. Lett, 7, pp.77~84 (2014)

관련 논문AI추천

Anti-Asthmatic Effects of Portulaca Oleracea and its Constituents, a ReviewAkbar Anaeigoudari, Majid Kianmehr, Mohammad Reza Khazdair대한약침학회 · Journal of Pharmacopuncture2019 · 제22권 제3호Anti-oxidative and Anti-inflammatory Effects of Protulaca Oleracea on the LPS-stimulated AGS Cells김재현, 김태현, 박평범, 이광규, 이창현, 정종길, 정한솔, 최승렬한의병리학회 · 동의생리병리학회지2009 · 제23권 제2호쇠비름 물, 에탄올 추출물의 항산화 및 항염증 활성강민정, 김동규, 신정혜한국식품저장유통학회 · Food Science and Preservation2018 · 제25권 제1호Opuntia dillenii: A Forgotten Plant with Promising Pharmacological PropertiesAmirhossein Sahebkar, Ashrafali Rezaie Kehkhaie, Hassan Rakhshandeh, Reza Shirazinia, Vafa Baradaran Rahimi, Vahid Reza Askari대한약침학회 · Journal of Pharmacopuncture2019 · 제22권 제1호마치현(Portulaca oleracea L.) 추출물의 항염 및 항소양 작용: LPS 처리로 염증을 유도한 Raw264.7세포와 각질형성세포, NC/Nga 마우스, Hairless 마우스에 대한 결과김명남, 김범준, 김정환, 김형미, 박원석, 신홍주, 임윤영대한천식알레르기학회 · 천식 및 알레르기2011 · 제31권 제3호馬齒莧이 DNCB로 유발된 생쥐의 알레르기성접촉피부염에 미치는 영향김종한, 박수연, 이종철, 최정화대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2014 · 제27권 제3호

이 간행물의 다른 논문 (5건)