Preclinical Evidence and Underlying Mechanisms of Polygonum multiflorum and Its Chemical Constituents Against Cognitive Impairments and Alzheimer’s Disease
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: Cognitive impairments, ranging from mild to severe, adversely affect daily functioning, quality of life, and work capacity. Despite significant efforts in the past decade, more than 200 promising drug candidates have failed in clinical trials. Herbal remedies are gaining interest as potential treatments for dementia due to their long history and safety, making them valuable for drug development. This review aimed to examine the mechanisms behind the effect of Polygonum multiflorum on cognitive function. Methods: This study focused primarily on the effects of Polygonum multiflorum and its chemical constituents on cognitive behavioral outcomes including the Morris water maze, the passive avoidance test, and the Y maze, as well as pathogenic targets of cognitive impairment and Alzheimer’s disease (AD) like amyloid deposition, amyloid precursor protein, tau hyperphosphorylation, and cognitive decline. Additionally, a thorough evaluation of the mechanisms behind Polygonum multiflorum’s impact on cognitive function was conducted. We reviewed the most recent data from preclinical research done on experimental models, particularly looking at Polygonum multiflorum’s effects on cognitive decline and AD. Results: According to recent research, Poligonum multiflorum and its bioactive components, stilbene, and emodin, influence cognitive behavioral results and regulate the pathological target of cognitive impairment and AD. Their mechanisms of action include reducing oxidative and mitochondrial damage, regulating neuroinflammation, halting apoptosis, and promoting increased neurogenesis and synaptogenesis. Conclusion: This review serves as a comprehensive compilation of current experiments on AD and other cognitive impairment models related to the therapeutic effects of Polygonum multiflorum. We believe that these findings can serve as a basis for future clinical trials and have potential applications in the treatment of human neurological disorders.
Abstract
Objectives: Cognitive impairments, ranging from mild to severe, adversely affect daily functioning, quality of life, and work capacity. Despite significant efforts in the past decade, more than 200 promising drug candidates have failed in clinical trials. Herbal remedies are gaining interest as potential treatments for dementia due to their long history and safety, making them valuable for drug development. This review aimed to examine the mechanisms behind the effect of Polygonum multiflorum on cognitive function. Methods: This study focused primarily on the effects of Polygonum multiflorum and its chemical constituents on cognitive behavioral outcomes including the Morris water maze, the passive avoidance test, and the Y maze, as well as pathogenic targets of cognitive impairment and Alzheimer’s disease (AD) like amyloid deposition, amyloid precursor protein, tau hyperphosphorylation, and cognitive decline. Additionally, a thorough evaluation of the mechanisms behind Polygonum multiflorum’s impact on cognitive function was conducted. We reviewed the most recent data from preclinical research done on experimental models, particularly looking at Polygonum multiflorum’s effects on cognitive decline and AD. Results: According to recent research, Poligonum multiflorum and its bioactive components, stilbene, and emodin, influence cognitive behavioral results and regulate the pathological target of cognitive impairment and AD. Their mechanisms of action include reducing oxidative and mitochondrial damage, regulating neuroinflammation, halting apoptosis, and promoting increased neurogenesis and synaptogenesis. Conclusion: This review serves as a comprehensive compilation of current experiments on AD and other cognitive impairment models related to the therapeutic effects of Polygonum multiflorum. We believe that these findings can serve as a basis for future clinical trials and have potential applications in the treatment of human neurological disorders.
참고문헌 (45)
- Poulos CJ, "A comprehensive approach to reablement in dementia", Alzheimers Dement(N Y), 3(3), pp.450~458 (2017)
- Hugo J, "Dementia and cognitive impairment : epidemiology, diagnosis, and treatment", Clin Geriatr Med, 30(3), pp.421~442 (2014)
- Gonzales MM, "Biological aging processes underlying cognitive decline and neurodegenerative disease", J Clin Invest, 132(10), pp.e158453~ (2022)
- Serý O, "Molecular mechanisms of neuropathological changes in Alzheimer’s disease : a review", Folia Neuropathol, 51(1), pp.1~9 (2013)
- Bondi MW, "Alzheimer’s disease : past, present, and future", J Int Neuropsychol Soc, 23(9-10), pp.818~831 (2017)
- Rao RV, "Ayurvedic medicinal plants for Alzheimer’s disease : a review", Alzheimers Res Ther, 4(3), pp.22~ (2012)
- Gregory J, "Neuroprotective herbs for the management of Alzheimer’s disease", Biomolecules, 11(4), pp.543~ (2021)
- Lin L, "Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb. : a review", J Ethnopharmacol, 159, pp.158~183 (2015)
- Chan YC, "Beneficial effects of different Polygonum multiflorum Thunb. extracts on memory and hippocampus morphology", J Nutr Sci Vitaminol(Tokyo), 48(6), pp.491~497 (2002)
- Chan YC, "Polygonum multiflorum extracts improve cognitive performance in senescence accelerated mice", Am J Chin Med, 31(2), pp.171~179 (2003)
- Zhou L, "Tetrahydroxystilbene glucoside improves the learning and memory of amyloid-β(1-42)-injected rats and may be connected to synaptic changes in the hippocampus", Can J Physiol Pharmacol, 90(11), pp.1446~1455 (2012)
- Xie M, "Cognitive enhancing and antioxidant effects of tetrahydroxystilbene glucoside in Aβ1-42-induced neurodegeneration in mice", J Integr Neurosci, 17(3-4), pp.355~365 (2018)
- Luo H, "Tetrahydroxy stilbene glucoside improved the behavioral disorders of APP695V717I transgenic mice by inhibiting the expression of Beclin-1 and LC3-II", J Tradit Chin Med, 35(3), pp.295~300 (2015)
- Zhang L, "Learning-memory deficit with aging in APP transgenic mice of Alzheimer’s disease and intervention by using tetrahydroxystilbene glucoside", Behav Brain Res, 173(2), pp.246~254 (2006)
- Wang R, "Changes in hippocampal synapses and learning-memory abilities in ageincreasing rats and effects of tetrahydroxystilbene glucoside in aged rats", Neuroscience, 149(4), pp.739~746 (2007)
- Shen C, "Tetrahydroxystilbene glucoside ameliorates memory and movement functions, protects synapses and inhibits α-synuclein aggregation in hippocampus and striatum in aged mice", Restor Neurol Neurosci, 33(4), pp.531~541 (2015)
- Chen YH, "2, 3, 5, 4’-tetrahydroxystilbene-2-O-beta-D-glucoside protects against neuronal cell death and traumatic brain injuryinduced pathophysiology", Aging(Albany NY), 14(6), pp.2607~2627 (2022)
- Chen T, "Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1", miR-134 in vivo, 2016, pp.190, 74~82
- Zeng P, "Emodin rescued hyperhomocysteinemia-induced dementia and Alzheimer’s disease-like features in rats", Int J Neuropsychopharmacol, 22(1), pp.57~70 (2019)
- Um MY, "Protective effect of Polygonum multiflorum Thunb on amyloid beta-peptide 25-35 induced cognitive deficits in mice", J Ethnopharmacol, 104(1-2), pp.144~148 (2006)
- Park HR, "PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice", Neurosci Lett, 617, pp.254~263 (2016)
- Ahn SM, "Neuroprotection and spatial memory enhancement of four herbal mixture extract in HT22 hippocampal cells and a mouse model of focal cerebral ischemia", BMC Complement Altern Med, 15, pp.202~ (2015)
- Park MY, "PMC-12, a prescription of traditional Korean medicine, improves amyloid β-induced cognitive deficits through modulation of neuroinflammation", Evid Based Complement Alternat Med, 2015, pp.768049~ (2015)
- Yin X, "Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3β pathway in cells and in APP", PS1 transgenic mice, 2018, pp.495(1), 672~678
- Zhang RY, "Anti-amyloidgenic and neurotrophic effects of tetrahydroxystilbene glucoside on a chronic mitochondrial dysfunction rat model induced by sodium azide", J Nat Med, 72(3), pp.596~606 (2018)
- Luo HB, "Tetrahydroxy stilbene glucoside reduces the cognitive impairment and overexpression of amyloid precursor protein induced by aluminum exposure", Neurosci Bull, 25(6), pp.391~396 (2009)
- Gao Y, "Tetrahydroxy stilbene glycoside ameliorates Alzheimer’s disease in APP", PS1 mice via glutathione peroxidase related ferroptosis, 2021, pp.99, 108002~
- Zhang L, "Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer’s disease", Restor Neurol Neurosci, 31(1), pp.41~52 (2013)
- He H, "Protective effects of 2, 3, 5, 4’-tetrahydroxystilbene-2-O-β-D-glucoside in the MPTP-induced mouse model of Parkinson’s disease : involvement of reactive oxygen species-mediated JNK, P38 and mitochondrial pathways", Eur J Pharmacol, 767, pp.175~182 (2015)
- Li X, "Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation", Neurosci Lett, 483(1), pp.1~5 (2010)
- Tao L, "Protective effect of tetrahydroxystilbene glucoside on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway", PLoS One, 6(10), pp.e26055~ (2011)
- Wang T, "Protection by tetrahydroxystilbene glucoside against cerebral ischemia : involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS", RNS generation, 2009, pp.47(3), 229~240
- Kim HN, "Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells", J Ethnopharmacol, 150(1), pp.108~115 (2013)
- Gao Y, "Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1", Parkin signaling pathway, 2020, pp.177, 113997~
- Jiao C, "Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU. 1 expression", Neuroreport, 29(10), pp.787~793 (2018)
- Zhang F, "Tetrahydroxystilbene glucoside attenuates neuroinflammation through the inhibition of microglia activation", Oxid Med Cell Longev, 2013, pp.680545~ (2013)
- Park SY, "Anti-neuroinflammatory effect of emodin in LPS-stimulated microglia : involvement of AMPK", Nrf2 activation, 2016, pp.41(11), 2981~2992
- Park SY, "Anti-inflammatory effects of novel polygonum multiflorum compound via inhibiting NF-κB", MAPK and upregulating the Nrf2 pathways in LPSstimulated microglia, 2017, pp.651, 43~51
- Park SY, "Novel compound from Polygonum multiflorum inhibits inflammatory response in LPS-stimulated microglia by upregulating AMPK", Nrf2 pathways, 2016, pp.100, 21~29
- Lee SY, "Neuroprotective effects of 2, 3, 5, 4’-tetrahydoxystilbene-2-O-β-Dglucoside from Polygonum multiflorum against glutamateinduced oxidative toxicity in HT22 cells", J Ethnopharmacol, 195, pp.64~70 (2017)
- Sun FL, "Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity", Eur J Pharmacol, 660(2-3), pp.283~290 (2011)
- Qin R, "Protection by tetrahydroxystilbene glucoside against neurotoxicity induced by MPP+ : the involvement of PI3K", Akt pathway activation, 2011, pp.202(1), 1~7
- Ahn SM, "Beneficial effects of Polygonum multiflorum on hippocampal neuronal cells and mouse focal cerebral ischemia", Am J Chin Med, 43(4), pp.637~651 (2015)
- Ren TT, "2, 3, 5, 4’-tetrahydoxystilbene-2-O-β-D-glucoside eliminates staurosporine-induced cytotoxicity by restoring BDNF-TrkB", Akt signaling axis, 2020, pp.17(14), 2207~2213
- Wang T, "Tetrahydroxystilbene glucoside, a plant-derived cognitive enhancer, promotes hippocampal synaptic plasticity", Eur J Pharmacol, 650(1), pp.206~214 (2011)
