Hair Growth Promotion with Black Soybean Extracts: case series
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초록
Black soybean (BS) is widely thought to prevent or alleviate hair loss, which has been demonstrated by in vitro experiments. However, few clinical studies have directly assessed the effect of BS on hair growth. To assess the safety and efficacy of BS, we administered BS extract to 10 adult patients for 3 months without any other hair products and treatments. The number and diameter of hair lost from washing were examined every 4 weeks. In addition, the participants’ satisfaction with their hair condition was also measured using the VAS (1 to 10) before and after treatment. The mean number of lost hair was 140.7 (SD 59.4) at baseline and 38.8 (SD 54.4) after 12 weeks, and the diameter of lost hair was 72.4 µm (SD 11.9) at baseline and 80.4 µm (SD 8.8) after 12 weeks, which indicated a statistically significant improvement (p = 0.002, p = 0.022, paired t-test). The satisfaction score was significantly increased from 6.10 (SD 1.2) to 8.2 (SD 1.1) after 12 weeks. These results suggest that BS extract may promote hair growth and prevent hair loss.
Abstract
Black soybean (BS) is widely thought to prevent or alleviate hair loss, which has been demonstrated by in vitro experiments. However, few clinical studies have directly assessed the effect of BS on hair growth. To assess the safety and efficacy of BS, we administered BS extract to 10 adult patients for 3 months without any other hair products and treatments. The number and diameter of hair lost from washing were examined every 4 weeks. In addition, the participants’ satisfaction with their hair condition was also measured using the VAS (1 to 10) before and after treatment. The mean number of lost hair was 140.7 (SD 59.4) at baseline and 38.8 (SD 54.4) after 12 weeks, and the diameter of lost hair was 72.4 µm (SD 11.9) at baseline and 80.4 µm (SD 8.8) after 12 weeks, which indicated a statistically significant improvement (p = 0.002, p = 0.022, paired t-test). The satisfaction score was significantly increased from 6.10 (SD 1.2) to 8.2 (SD 1.1) after 12 weeks. These results suggest that BS extract may promote hair growth and prevent hair loss.
참고문헌 (21)
- Arase S, "Co-culture of human hair follicles and dermal papillae in a collagen matrix", J Dermatol, 17(11), pp.667~676 (1990)
- Zhao J, "Treatment of alopecia by transplantation of hair follicle stem cells and dermal papilla cells encapsulated in alginate gels", Med Hypotheses, 70(5), pp.1014~1016 (2008)
- Stenn KS, "Hair follicle growth controls", Dermatol Clin, 14(4), pp.543~558 (1996)
- Stenn KS, "Controls of hair follicle cycling", Physiol Rev, 81(1), pp.449~494 (2001)
- Jones LN, "The role of 18-methyleicosanoic acid in the structure and formation of mammalian hair fibres", Micron, 28(6), pp.469~485 (1997)
- Kovalenko IV, "Determination of amino acid composition of soybeans (Glycine max) by nearinfrared spectroscopy", J Agric Food Chem, 54(10), pp.3485~3491 (2006)
- Maeda H, "High correlation between lipid peroxide radical and tumor-promoter effect:suppression of tumor promotion in the Epstein-Barr virus", Blymphocyte system and scavenging of alkyl peroxide radicals by various vegetable extracts, 1992, pp.83(9), 923~928
- and its effect on proliferation and differentiation of human leukemic U937 cells, "Anticancer Drugs", 2001, 841~846
- Jang EH, "Novel black soy peptides with antiobesity effects : activation of leptin-like signaling and AMP-activated protein kinase", Int J Obes (Lond), 32(7), pp.1161~1170 (2008)
- Kim HJ, "Purification and identification of adipogenesis inhibitory peptide from black soybean protein hydrolysate", Peptides, 28(11), pp.2098~2103 (2007)
- Zhao QW, "Estrogenic activity and its mechanism of ethanol extract from black soybean", Zhongguo Zhong Yao Za Zhi, 31(10), pp.825~828 (2006)
- Takahashi R, "Antioxidant activities of black and yellow soybeans against low density lipoprotein oxidation", J Agric Food Chem, 53(11), pp.4578~4582 (2005)
- Kim K, "Black soybean extract can attenuate thrombosis through inhibition of collagen-induced platelet activation", J Nutr Biochem, 22(10), pp.964~970 (2011)
- Shimizu T, "Effects of n-3 polyunsaturated fatty acids and vitamin E on colonic mucosal leukotriene generation, lipid peroxidation, and microcirculation in rats with experimental colitis", Digestion, 63(1), pp.49~54 (2001)
- Lee SJ, "Bonchokangmok", pp.137~148 (2007), Yeoil Publishing Co
- Huh J, "Donguibogam", pp.307~310 (1992), DS Print Co
- Choi SM, "Hair growth effects of Sangmosu in mice", Yakhak Hoeji, 43(3), pp.351~357 (1999)
- 허진주, "C57BL6 마우스에서 복합생약제인 황금궁의 육모 효과", 약 학 회 지, 49(6), pp.518~526 (2005), 대한약학회
- 전희영, "In vitro 및 in vivo에서 검은콩 추출물의 육모 효과", 한국식품과학회지, 43(6), pp.747~753 (2011), 한국식품과학회
- Suzuki K, "Allergic contact dermatitis from minoxidil : study of the cross-reaction to minoxidil", Am J Contact Dermat, 13(1), pp.45~46 (2002)
- Mella JM, "Efficacy and safety of finasteride therapy for androgenetic alopecia : a systematic review", Arch Dermatol, 146(10), pp.1141~1150 (2010)