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Oral Pathogens and Their Antibiotics from Marine Organisms: A Systematic Review of New Drugs for Novel Drug Targets

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Background: Recent studies have elucidated the quorum-sensing mechanisms, biofilm formation, inter-pathogen interactions, and genes related to oral pathogens. This review aims to explore the recent expansion of drug targets against oral pathogens and summarize the current research on novel antibiotic substances derived from marine organisms that target oral pathogens. Methods: A comprehensive literature review summarized the novel mechanisms pertaining to quorum-sensing signal transmission systems, biofilm formation, and metabolite exchange in oral pathogens. The amino acid sequences of the 16 proteins identified as potential drug targets were systematically classified and compared across various oral microorganisms. Results: Through a literature review, we identified nine studies researching quorum sensing signaling inhibitors targeting oral pathogens. A comparison of the amino acid sequences of 16 potential drug targets in oral microorganisms revealed significant differences between oral pathogens and beneficial oral symbiotic microorganisms. These findings imply that it is possible to design drugs that can bind more selectively to oral pathogens. Conclusion: By summarizing the results of recent research on the signaling mechanisms that cause pathogenicity, new drug targets against oral pathogens were proposed. Additionally, the current status of developing new antibiotics for oral pathogens using recently developed quorum sensing inhibitors and natural products derived from marine organisms was introduced. Consequently, marine natural products can be used to develop drugs targeting new proteins in oral pathogens.

Abstract

Background: Recent studies have elucidated the quorum-sensing mechanisms, biofilm formation, inter-pathogen interactions, and genes related to oral pathogens. This review aims to explore the recent expansion of drug targets against oral pathogens and summarize the current research on novel antibiotic substances derived from marine organisms that target oral pathogens. Methods: A comprehensive literature review summarized the novel mechanisms pertaining to quorum-sensing signal transmission systems, biofilm formation, and metabolite exchange in oral pathogens. The amino acid sequences of the 16 proteins identified as potential drug targets were systematically classified and compared across various oral microorganisms. Results: Through a literature review, we identified nine studies researching quorum sensing signaling inhibitors targeting oral pathogens. A comparison of the amino acid sequences of 16 potential drug targets in oral microorganisms revealed significant differences between oral pathogens and beneficial oral symbiotic microorganisms. These findings imply that it is possible to design drugs that can bind more selectively to oral pathogens. Conclusion: By summarizing the results of recent research on the signaling mechanisms that cause pathogenicity, new drug targets against oral pathogens were proposed. Additionally, the current status of developing new antibiotics for oral pathogens using recently developed quorum sensing inhibitors and natural products derived from marine organisms was introduced. Consequently, marine natural products can be used to develop drugs targeting new proteins in oral pathogens.

참고문헌 (95)

  1. Takahashi N, "Oral microbiome metabolism : from"who are they?"to"what are they doing?"", J Dent Res, 94, pp.1628~1637 (2015)[DOI]
  2. Xu X, "Oral cavity contains distinct niches with dynamic microbial communities", Environ Microbiol, 17, pp.699~710 (2015)[DOI]
  3. Bowen WH, "Oral biofilms : pathogens, matrix, and polymicrobial interactions in microenvironments", Trends Microbiol, 26, pp.229~242 (2018)[DOI]
  4. Marsh PD, "Microbiology of dental plaque biofilms and their role in oral health and caries", Dent Clin North Am, 54, pp.441~454 (2010)[DOI]
  5. Marsh PD, "Dental plaque as a biofilm and a microbial community-implications for health and disease", BMC Oral Health 6 Suppl, 1, pp.S14~ (2006)[DOI]
  6. Debelian GJ, "Systemic diseases caused by oral microorganisms", Endod Dent Traumatol, 10, pp.57~65 (1994)[DOI]
  7. Beck JD, "Systemic effects of periodontitis : epidemiology of periodontal disease and cardiovascular disease", J Periodontol, 76, pp.2089~2100 (2005)[DOI]
  8. Borgnakke WS, "Effect of periodontal disease on diabetes : systematic review of epidemiologic observational evidence", J Clin Periodontol, 40, pp.S135~S152 (2013)[DOI]
  9. Olsen I, "Possible role of Porphyromonas gingivalis in orodigestive cancers", J Oral Microbiol, 11, pp.1563410~ (2019)[DOI]
  10. Könönen E, "Prevotella species as oral residents and infectious agents with potential impact on systemic conditions", J Oral Microbiol, 14, pp.2079814~ (2022)[DOI]
  11. Issrani R, "Exploring the mechanisms and association between oral microflora and systemic diseases", Diagnostics(Basel), 12, pp.2800~ (2022)[DOI]
  12. Aas JA, "Bacteria of dental caries in primary and permanent teeth in children and young adults", J Clin Microbiol, 46, pp.1407~1417 (2008)[DOI]
  13. Yanagisawa M, "Proteinase activity of Prevotella species associated with oral purulent infection", Curr Microbiol, 52, pp.375~378 (2006)[DOI]
  14. Neilands J, "Bacterial profiles and proteolytic activity in peri-implantitis versus healthy sites", Anaerobe, 35, pp.28~34 (2015)[DOI]
  15. van Winkelhoff AJ, "Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction", J Clin Periodontol, 29, pp.1023~1028 (2002)[DOI]
  16. Bostanci N, "Porphyromonas gingivalis : an invasive and evasive opportunistic oral pathogen", FEMS Microbiol Lett, 333, pp.1~9 (2012)[DOI]
  17. Bao K, "Role of Porphyromonas gingivalis gingipains in multi-species biofilm formation", BMC Microbiol, 14, pp.258~ (2014)[DOI]
  18. Scannapieco FA, "Role of oral bacteria in respiratory infection", J Periodontol, 70, pp.793~802 (1999)[DOI]
  19. Williams D, "Pathogenesis and treatment of oral candidosis", J Oral Microbiol, 3, pp.5771~ (2011)[DOI]
  20. Vila T, "Oral candidiasis: a disease of opportunity", J Fungi (Basel), 6, pp.15~ (2020)[DOI]
  21. Patil S, "Microbial flora in oral diseases", J Contemp Dent Pract, 14, pp.1202~1208 (2013)[DOI]
  22. Deepa A, "Uncommon opportunistic fungal infections of oral cavity : a review", J Oral Maxillofac Pathol, 18, pp.235~243 (2014)[DOI]
  23. Seifert HS, "Location, location, location-commensalism, damage and evolution of the pathogenic Neisseria", J Mol Biol, 431, pp.3010~3014 (2019)[DOI]
  24. Giacomini JJ, "Spatial ecology of Haemophilus and Aggregatibacter in the human oral cavity", Microbiol Spectr, 12, pp.e0401723~ (2024)[DOI]
  25. Jakubovics NS, "The road to ruin : the formation of disease-associated oral biofilms", Oral Dis, 16, pp.729~739 (2010)[DOI]
  26. Kolenbrander PE, "Oral multispecies biofilm development and the key role of cell-cell distance", Nat Rev Microbiol, 8, pp.471~480 (2010)[DOI]
  27. Hasty DL, "Multiple adhesins of streptococci", Infect Immun, 60, pp.2147~2152 (1992)[DOI]
  28. Jakubovics NS, "Functions of cell surface-anchored antigen I", II family and Hsa polypeptides in interactions of Streptococcus gordonii with host receptors, 2005, pp.73, 6629~6638
  29. Jakubovics NS, "Differential binding specificities of oral streptococcal antigen I", II family adhesins for human or bacterial ligands, 2005, pp.55, 1591~1605
  30. Llor C, "Antimicrobial resistance : risk associated with antibiotic overuse and initiatives to reduce the problem", Ther Adv Drug Saf, 5, pp.229~241 (2014)[DOI]
  31. Wright GD, "New strategies for combating multidrug-resistant bacteria", Trends Mol Med, 13, pp.260~267 (2007)[DOI]
  32. Alonso A, "Emergence of multidrug-resistant mutants is increased under antibiotic selective pressure in Pseudomonas aeruginosa", Microbiology, 145, pp.2857~2862 (1999)[DOI]
  33. Terreni M, "New antibiotics for multidrug-resistant bacterial strains : latest research developments and future perspectives", Molecules, 26, pp.2671~ (2021)[DOI]
  34. Brooks L, "Prevalence of antibiotic resistance genes in the oral cavity and mobile genetic elements that disseminate antimicrobial resistance : a systematic review", Mol Oral Microbiol, 37, pp.133~153 (2022)[DOI]
  35. Demain AL, "Antibiotics : natural products essential to human health", Med Res Rev, 29, pp.821~842 (2009)[DOI]
  36. Demain AL, "Importance of microbial natural products and the need to revitalize their discovery", J Ind Microbiol Biotechnol, 41, pp.185~201 (2014)[DOI]
  37. Moloney MG, "Natural products as a source for novel antibiotics", Trends Pharmacol Sci, 37, pp.689~701 (2016)[DOI]
  38. Mehbub MF, "New marine natural products from sponges(Porifera)of the order Dictyoceratida(2001 to 2012); a promising source for drug discovery, exploration and future prospects", Biotechnol Adv, 34, pp.473~491 (2016)[DOI]
  39. Stonik VA, "Antibiotics from marine bacteria", Biochemistry (Mosc), 85, pp.1362~1373 (2020)[DOI]
  40. Fiedler HP, "Marine actinomycetes as a source of novel secondary metabolites", Antonie Van Leeuwenhoek, 87, pp.37~42 (2005)[DOI]
  41. Jagannathan SV, "Marine actinomycetes, new sources of biotechnological products", Mar Drugs, 19, pp.365~ (2021)[DOI]
  42. Deng Y, "Marine natural products and their synthetic analogs as promising antibiofilm agents for antibiotics discovery and development", Eur J Med Chem, 239, pp.114513~ (2022)[DOI]
  43. Liu M, "Antibacterial activity and mechanisms of depolymerized fucoidans isolated from Laminaria japonica", Carbohydr Polym, 172, pp.294~305 (2017)[DOI]
  44. Oka S, "Properties of fucoidans beneficial to oral healthcare", Odontology, 108, pp.34~42 (2020)[DOI]
  45. Senthilkumar K, "Brown seaweed fucoidan : biological activity and apoptosis, growth signaling mechanism in cancer", Int J Biol Macromol, 60, pp.366~374 (2013)[DOI]
  46. Fitton JH, "Therapies from fucoidan; multifunctional marine polymers", Mar Drugs, 9, pp.1731~1760 (2011)[DOI]
  47. de A. Lima B, "Halistanol sulfate A and rodriguesines A and B are antimicrobial and antibiofilm agents against the cariogenic bacterium Streptococcus mutans", Rev Bras Farmacogn, 24, pp.651~659 (2014)[DOI]
  48. Fusetani N, "Bioactive marine metabolites II. Halistanol sulfate, an antimicrobial novel steroid sulfate from the marine sponge Halichondria cf. Moorei bergquist", Tetrahedron Lett, 22, pp.1985~1988 (1981)[DOI]
  49. Schneemann I, "Mayamycin, a cytotoxic polyketide from a Streptomyces strain isolated from the marine sponge Halichondria panicea", J Nat Prod, 73, pp.1309~1312 (2010)[DOI]
  50. "J Antibiot (Tokyo)", 2009, 519~526, 10.1038[DOI]
  51. Sabido EM, "Marine sediment-derived Streptomyces strain produces angucycline antibiotics against multidrug-resistant Staphylococcus aureus harboring SCCmec type 1 gene", J Mar Sci Eng, 8, pp.734~ (2020)[DOI]
  52. Radjasa OK, "Antibacterial activity of marine bacterium Pseudomonas sp. Associated with soft coral Sinularia polydactyla against Streptococcus equi subsp. Zooepidemicus", Int J Pharmacol, 3, pp.170~174 (2007)[DOI]
  53. Noga EJ, "Primary structure and cellular localization of callinectin, an antimicrobial peptide from the blue crab", Dev Comp Immunol, 35, pp.409~415 (2011)[DOI]
  54. Fernández-Peña L, "Recent advances in biologically active coumarins from marine sources : synthesis and evaluation", Mar Drugs, 21, pp.37~ (2023)[DOI]
  55. He Z, "Anti-biofilm activities of coumarin as quorum sensing inhibitor for Porphyromonas gingivalis", J Oral Microbiol, 14, pp.2055523~ (2022)[DOI]
  56. Wright CJ, "Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors", Mol Oral Microbiol, 29, pp.185~193 (2014)[DOI]
  57. Abdelmohsen UR, "Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections", Lancet Infect Dis, 17, pp.e30~e41 (2017)[DOI]
  58. Kumar R, "Aurantoside K, a new antifungal tetramic acid glycoside from a Fijian marine sponge of the genus Melophlus", Mar Drugs, 10, pp.200~208 (2012)[DOI]
  59. Sbordone L, "Oral microbial biofilms and plaque-related diseases : microbial communities and their role in the shift from oral health to disease", Clin Oral Investig, 7, pp.181~188 (2003)[DOI]
  60. Kilian M, "The oral microbiome-friend or foe?", Eur J Oral Sci, 126, pp.5~12 (2018)[DOI]
  61. Sultan AS, "The oral microbiome : a lesson in coexistence", PLoS Pathog, 14, pp.e1006719~ (2018)[DOI]
  62. Dewhirst FE, "The human oral microbiome", J Bacteriol, 192, pp.5002~5017 (2010)[DOI]
  63. Baty JJ, "Oral commensal streptococci : gatekeepers of the oral cavity", J Bacteriol, 204, pp.e0025722~ (2022)[DOI]
  64. Hutcherson JA, "Amixicile, a novel strategy for targeting oral anaerobic pathogens", Sci Rep, 7, pp.10474~ (2017)[DOI]
  65. Gui Q, "Amixicile targets anaerobic bacteria within the oral microbiome", J Oral Biosci, 61, pp.226~235 (2019)[DOI]
  66. Pérot S, "Druggable pockets and binding site centric chemical space : a paradigm shift in drug discovery", Drug Discov Today, 15, pp.656~667 (2010)[DOI]
  67. Stone VN, "Targeted antimicrobial therapy in the microbiome era", Mol Oral Microbiol, 32, pp.446~454 (2017)[DOI]
  68. Soga S, "Use of amino acid composition to predict ligand-binding sites", J Chem Inf Model, 47, pp.400~406 (2007)[DOI]
  69. Fuqua WC, "Quorum sensing in bacteria : the LuxR-LuxI family of cell density-responsive transcriptional regulators", J Bacteriol, 176, pp.269~275 (1994)[DOI]
  70. Shao H, "Quorum sensing regulation of biofilm growth and gene expression by oral bacteria and periodontal pathogens", Periodontol 2000, 52, pp.53~67 (2010)[DOI]
  71. Niazy AA, "LuxS quorum sensing system and biofilm formation of oral microflora : a short review article", Saudi Dent J, 33, pp.116~123 (2021)[DOI]
  72. Stewart PS, "Antibiotic resistance of bacteria in biofilms", Lancet, 358, pp.135~138 (2001)[DOI]
  73. Høiby N, "Antibiotic resistance of bacterial biofilms", Int J Antimicrob Agents, 35, pp.322~332 (2010)[DOI]
  74. Jenkinson HF, "Structure, function and immunogenicity of streptococcal antigen I", II polypeptides, 1997, pp.23, 183~190
  75. Ahn SJ, "Characteristics of biofilm formation by Streptococcus mutans in the presence of saliva", Infect Immun, 76, pp.4259~4268 (2008)[DOI]
  76. Arciola CR, "Polysaccharide intercellular adhesin in biofilm : structural and regulatory aspects", Front Cell Infect Microbiol, 5, pp.7~ (2015)[DOI]
  77. Sharma A, "Synergy between Tannerella forsythia and Fusobacterium nucleatum in biofilm formation", Oral Microbiol Immunol, 20, pp.39~42 (2005)[DOI]
  78. Okuda T, "Synergy in biofilm formation between Fusobacterium nucleatum and Prevotella species", Anaerobe, 18, pp.110~116 (2012)[DOI]
  79. Sarangi AN, "Subtractive genomics approach for in silico identification and characterization of novel drug targets in Neisseria meningitides serogroup B", J Comput Sci Syst Biol, 2, pp.255~258 (2009)[DOI]
  80. Gerits E, "New approaches to combat Porphyromonas gingivalis biofilms", J Oral Microbiol, 9, pp.1300366~ (2017)[DOI]
  81. Rasmussen TB, "Quorum-sensing inhibitors as anti-pathogenic drugs", Int J Med Microbiol, 296, pp.149~161 (2006)[DOI]
  82. Haque S, "Developments in strategies for quorum sensing virulence factor inhibition to combat bacterial drug resistance", Microb Pathog, 121, pp.293~302 (2018)[DOI]
  83. Chung WO, "Signaling system in Porphyromonas gingivalis based on a LuxS protein", J Bacteriol, 183, pp.3903~3909 (2001)[DOI]
  84. Frias J, "Periodontal pathogens produce quorum sensing signal molecules", Infect Immun, 69, pp.3431~3434 (2001)[DOI]
  85. Kolenbrander PE, "Bacterial interactions and successions during plaque development", Periodontol 2000, 42, pp.47~79 (2006)[DOI]
  86. Jang YJ, "Autoinducer 2of Fusobacterium nucleatum as a target molecule to inhibit biofilm formation of periodontopathogens", Arch Oral Biol, 58, pp.17~27 (2013)[DOI]
  87. Senadheera D, "Quorum sensing and biofilm formation by Streptococcus mutans", Adv Exp Med Biol, 631, pp.178~188 (2008)[DOI]
  88. Shao H, "Autoinducer 2 is required for biofilm growth of Aggregatibacter(Actinobacillus)actinomycetemcomitans", Infect Immun, 75, pp.4211~4218 (2007)[DOI]
  89. Cho YJ, "In vivo inhibition of Porphyromonas gingivalis growth and prevention of periodontitis with quorum-sensing inhibitors", J Periodontol, 87, pp.1075~1082 (2016)[DOI]
  90. Ryu EJ, "D-galactose as an autoinducer 2 inhibitor to control the biofilm formation of periodontopathogens", J Microbiol, 54, pp.632~637 (2016)[DOI]
  91. An SJ, "Inhibitory effect of D-arabinose on oral bacteria biofilm formation on titanium discs", Anaerobe, 75, pp.102533~ (2022)[DOI]
  92. Park T, "Short-chain fatty acids inhibit the biofilm formation of Streptococcus gordonii through negative regulation of competence-stimulating peptide signaling pathway", J Microbiol, 59, pp.1142~1149 (2021)[DOI]
  93. Park JS, "New bicyclic brominated furanones as potent autoinducer-2 quorumsensing inhibitors against bacterial biofilm formation", Eur J Med Chem, 137, pp.76~87 (2017)[DOI]
  94. Chen Y, "Baicalein inhibits Staphylococcus aureus biofilm formation and the quorum sensing system in vitro", PLoS One, 11, pp.e0153468~ (2016)[DOI]
  95. He Z, "Use of the quorum sensing inhibitor furanone C-30 to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain", Int J Antimicrob Agents, 40, pp.30~35 (2012)[DOI]

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