Magnetization-tagged MRI is a simple method for predicting liver fibrosis
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Background/Aims: To assess the usefulness of magnetization-tagged magnetic resonance imaging (MRI) in quantifying cardiac-induced liver motion and deformation in order to predict liver fibrosis. Methods: This retrospective study included 85 patients who underwent liver MRI including magnetization-tagged sequences from April 2010 to August 2010. Tagged images were acquired in three coronal and three sagittal planes encompassing both the liver and heart. A Gabor filter bank was used to measure the maximum value of displacement (MaxDisp) and the maximum and minimum values of principal strains (MaxP1 and MinP2, respectively). Patients were divided into three groups (no fibrosis, mild-to-moderate fibrosis, and significant fibrosis) based on their aspartate-aminotransferase-to-platelet ratio index (APRI) score. Group comparisons were made using ANOVA tests. Results: The patients were divided into three groups according to APRI scores: no fibrosis (≤0.5; n=41), moderate fibrosis (0.5–1.5; n=23), and significant fibrosis (>1.5; n=21). The values of MaxDisp were 2.9±0.9 (mean±SD), 2.3±0.7, and 2.1±0.6 in the no fibrosis, moderate fibrosis, and significant fibrosis groups, respectively (P<0.001); the corresponding values of MaxP1 were 0.05±0.2, 0.04±0.02, and 0.03±0.01, respectively (P=0.002), while those of MinP2 were –0.07±0.02, –0.05±0.02, and –0.04±0.01, respectively (P<0.001). Conclusions: Tagged MRI to quantify cardiac-induced liver motion can be easily incorporated in routine liver MRI and may represent a helpful complementary tool in the diagnosis of early liver fibrosis.
Abstract
Background/Aims: To assess the usefulness of magnetization-tagged magnetic resonance imaging (MRI) in quantifying cardiac-induced liver motion and deformation in order to predict liver fibrosis. Methods: This retrospective study included 85 patients who underwent liver MRI including magnetization-tagged sequences from April 2010 to August 2010. Tagged images were acquired in three coronal and three sagittal planes encompassing both the liver and heart. A Gabor filter bank was used to measure the maximum value of displacement (MaxDisp) and the maximum and minimum values of principal strains (MaxP1 and MinP2, respectively). Patients were divided into three groups (no fibrosis, mild-to-moderate fibrosis, and significant fibrosis) based on their aspartate-aminotransferase-to-platelet ratio index (APRI) score. Group comparisons were made using ANOVA tests. Results: The patients were divided into three groups according to APRI scores: no fibrosis (≤0.5; n=41), moderate fibrosis (0.5–1.5; n=23), and significant fibrosis (>1.5; n=21). The values of MaxDisp were 2.9±0.9 (mean±SD), 2.3±0.7, and 2.1±0.6 in the no fibrosis, moderate fibrosis, and significant fibrosis groups, respectively (P<0.001); the corresponding values of MaxP1 were 0.05±0.2, 0.04±0.02, and 0.03±0.01, respectively (P=0.002), while those of MinP2 were –0.07±0.02, –0.05±0.02, and –0.04±0.01, respectively (P<0.001). Conclusions: Tagged MRI to quantify cardiac-induced liver motion can be easily incorporated in routine liver MRI and may represent a helpful complementary tool in the diagnosis of early liver fibrosis.
참고문헌 (21)
- Dufour JF, "Regression of hepatic fibrosis in hepatitis C with long-term interferon treatment", Dig Dis Sci, 43, pp.2573~2576 (1998)
- Wanless IR, "Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis", Arch Pathol Lab Med, 124, pp.1599~1607 (2000)
- Malekzadeh R, "Reversibility of cirrhosis in autoimmune hepatitis", Am J Med, 117, pp.125~129 (2004)
- Afdhal NH, "Evaluation of liver fibrosis: a concise review", Am J Gastroenterol, 99, pp.1160~1174 (2004)
- Hølund B, "Reproducibility of liver biopsy diagnosis in relation to the size of the specimen", Scand J Gastroenterol, 15, pp.329~335 (1980)
- Sandrin L, "Transient elastography: a new noninvasive method for assessment of hepatic fibrosis", Ultrasound Med Biol, 29, pp.1705~1713 (2003)
- Foucher J, "Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study", Gut, 55, pp.403~408 (2006)
- Cobbold JF, "Transient elastography for the assessment of chronic liver disease: ready for the clinic?", World J Gastroenterol, 13, pp.4791~4797 (2007)
- Asbach P, "Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography", Radiology, 257, pp.80~86 (2010)
- Foucher J, "Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations", Eur J Gastroenterol Hepatol, 18, pp.411~412 (2006)
- Muthupillai R, "Magnetic resonance elastography by direct visualization of propagating acoustic strain waves", Science, 269, pp.1854~1857 (1995)
- Chung S, "Liver stiffness assessment by tagged MRI of cardiac-induced liver motion", Magn Reson Med, 65, pp.949~955 (2011)
- Wai CT, "A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C", Hepatology, 38, pp.518~526 (2003)
- Snyder N, "APRI: an easy and validated predictor of hepatic fibrosis in chronic hepatitis C", J Clin Gastroenterol, 40, pp.535~542 (2006)
- Huwart L, "Liver fibrosis: noninvasive assessment with MR elastography versus aspartate aminotransferase-to-platelet ratio index", Radiology, 245, pp.458~466 (2007)
- Castéra L, "Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C", Gastroenterology, 128, pp.343~350 (2005)
- Chang PE, "Prospective evaluation of transient elastography for the diagnosis of hepatic fibrosis in Asians: comparison with liver biopsy and aspartate transaminase platelet ratio index", Aliment Pharmacol Ther, 28, pp.51~61 (2008)
- Chung S, "Liver stiffness assessment with tagged MRI of cardiac-induced liver motion in cirrhosis patients", J Magn Reson Imaging, 39, pp.1301~1307 (2014)
- Merboldt KD, "Spatially encoded phasecontrast MRI-3D MRI movies of 1D and 2D structures at millisecond resolution", Magn Reson Med, 66, pp.950~956 (2011)
- Axel L, "MR imaging of motion with spatial modulation of magnetization", Radiology, 171, pp.841~845 (1989)
- Watanabe H, "MR elastography of the liver at 3 T with cinetagging and bending energy analysis: preliminary results", Eur Radiol, 20, pp.2381~2389 (2010)