Predicting factors of present hepatitis C virus infection among patients positive for the hepatitis C virus antibody
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Background/Aims: To identify the predicting factors of present hepatitis C virus (HCV) infection among patients with positivity for antibodies to HCV (anti-HCV). Methods: We analyzed patients who showed positive enzyme immunoassay (EIA) results and performed an HCV RNA test as a confirmatory test at Kyung Hee University Hospital at Gangdong from June 2006 to July 2012. The features distinguishing the groups with positive and negative HCV RNA results were reviewed. Results: In total, 490 patients were included. The results of the HCV RNA test were positive and negative in 228 and 262 patients, respectively. The index value of anti-HCV, mean age, platelet counts, total bilirubin, prothrombin time international normalized ratio, albumin and alanine transaminase (ALT) levels differed significantly between the two groups. On multivariable analysis, an index value of anti-HCV >10 [odds ratio (OR)=397.27, P<0.001), ALT >40 IU/L (OR=3.64, P=0.001), and albumin <3.8 g/dL (OR=2.66, P=0.014) were related to present HCV infection. Conclusions: Although EIA is not a quantitative test, considering the anti-HCV titer with ALT and albumin levels may be helpful in predicting present of HCV infection. (Clin Mol Hepatol 2013;19:376-381)
Abstract
Background/Aims: To identify the predicting factors of present hepatitis C virus (HCV) infection among patients with positivity for antibodies to HCV (anti-HCV). Methods: We analyzed patients who showed positive enzyme immunoassay (EIA) results and performed an HCV RNA test as a confirmatory test at Kyung Hee University Hospital at Gangdong from June 2006 to July 2012. The features distinguishing the groups with positive and negative HCV RNA results were reviewed. Results: In total, 490 patients were included. The results of the HCV RNA test were positive and negative in 228 and 262 patients, respectively. The index value of anti-HCV, mean age, platelet counts, total bilirubin, prothrombin time international normalized ratio, albumin and alanine transaminase (ALT) levels differed significantly between the two groups. On multivariable analysis, an index value of anti-HCV >10 [odds ratio (OR)=397.27, P<0.001), ALT >40 IU/L (OR=3.64, P=0.001), and albumin <3.8 g/dL (OR=2.66, P=0.014) were related to present HCV infection. Conclusions: Although EIA is not a quantitative test, considering the anti-HCV titer with ALT and albumin levels may be helpful in predicting present of HCV infection. (Clin Mol Hepatol 2013;19:376-381)
참고문헌 (14)
- Ghany MG, "Diagnosis, management, and treatment of hepatitis C: an update", Hepatology, 49, pp.1335~1374 (2009)
- European Association for the Study of the Liver, "EASL Clinical Practice Guidelines: management of hepatitis C virus infection", J Hepatol, 55, pp.245~264 (2011)
- 박승국, "대구.경북 지역 성인의 바이러스성 간염 표지자 양성률에 관한 연구-건강검진 수진자를 대상으로-", 대한소화기학회지, 41(6), pp.473~479 (2003), 대한소화기학회
- Na HY, "Geographic Characteristics of Positivity of Anti - HCV and Chonnam Province: Survey Data of 6, 790 Health Screenees", Korean J Gastroenterol, 38, pp.177~184 (2001)
- Viral hepatitis surveillance system and statue of C hepatitis sentinel surveillance in Korea, "Kim SJ", KCDC, 214~219, pp.Public Health Weekly Report,5 (2012)
- Alter MJ, "Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention", MMWR Recomm Rep, 52, pp.1~13 (2003)
- Colin C, "Sensitivity and specificity of third-generation hepatitis C virus antibody detection assays: an analysis of the literature", J Viral Hepat, 8, pp.87~95 (2001)
- Denoyel G, "Performance of a new hepatitis C assay on the Bayer ADVIA centaur immunoassay system", Clin lab, 50, pp.75~82 (2004)
- Vermehren J, "Differences between two real-time PCR-based hepatitis C virus (HCV) assays (RealTime HCV and Cobas AmpliPrep", Cobas TaqMan) and one signal amplification assay (Versant HCV RNA 3.0) for RNA detection and quantification, 2008, pp.46, 3880~3891
- Nolte FS, "Prospective multicenter clinical evaluation of AMPLICOR and COBAS AMPLICOR hepatitis C virus tests", J Clin Microbiol, 39, pp.4005~4012 (2001)
- Oh EJ, "Different signal-to-cut-off ratios from three automated anti-hepatitis C virus chemiluminescence immunoassays in relation to results of recombinant immunoblot assays and nucleic acid testing", Blood Transfus, 11, pp.471~473 (2013)
- Moretti M, "Role of signal-to-cutoff ratios in hepatitis C virus antibody detection", Clin Vaccine Immunol, 19, pp.1329~1331 (2012)
- Stramer SL, "The value of screening signal-to-cutoff ratios for hepatitis C virus antibody confirmation", Transfusion, 53, pp.1497~1500 (2013)
- Eslam M, "Insulin resistance and hepatitis C: an evolving story", Gut, 60, pp.1139~1151 (2011)