The emerging roles of extracellular vesicles as intercellular messengers in liver physiology and pathology
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Extracellular vesicles (EVs) are membrane-enclosed particles released from almost all cell types. EVs mediate intercellular communication by delivering their surface and luminal cargoes, including nucleic acids, proteins, and lipids, which reflect the pathophysiological conditions of their cellular origins. Hepatocytes and hepatic non-parenchymal cells utilize EVs to regulate a wide spectrum of biological events inside the liver and transfer them to distant organs through systemic circulation. The liver also receives EVs from multiple organs and integrates these extrahepatic signals that participate in pathophysiological processes. EVs have recently attracted growing attention for their crucial roles in maintaining and regulating hepatic homeostasis. This review summarizes the roles of EVs in intrahepatic and interorgan communications under different pathophysiological conditions of the liver, with a focus on chronic liver diseases including nonalcoholic steatohepatitis, alcoholic hepatitis, viral hepatitis, liver fibrosis, and hepatocellular carcinoma. This review also discusses recent progress for potential therapeutic applications of EVs by targeting or enhancing EV-mediated cellular communication for the treatment of liver diseases.
Abstract
Extracellular vesicles (EVs) are membrane-enclosed particles released from almost all cell types. EVs mediate intercellular communication by delivering their surface and luminal cargoes, including nucleic acids, proteins, and lipids, which reflect the pathophysiological conditions of their cellular origins. Hepatocytes and hepatic non-parenchymal cells utilize EVs to regulate a wide spectrum of biological events inside the liver and transfer them to distant organs through systemic circulation. The liver also receives EVs from multiple organs and integrates these extrahepatic signals that participate in pathophysiological processes. EVs have recently attracted growing attention for their crucial roles in maintaining and regulating hepatic homeostasis. This review summarizes the roles of EVs in intrahepatic and interorgan communications under different pathophysiological conditions of the liver, with a focus on chronic liver diseases including nonalcoholic steatohepatitis, alcoholic hepatitis, viral hepatitis, liver fibrosis, and hepatocellular carcinoma. This review also discusses recent progress for potential therapeutic applications of EVs by targeting or enhancing EV-mediated cellular communication for the treatment of liver diseases.
참고문헌 (139)
- Théry C, "Minimal information for studies of extracellular vesicles 2018(MISEV2018) : a position statement of the international society for extracellular vesicles and update of the MISEV2014 guidelines", J Extracell Vesicles, 7, pp.1535750~ (2018)
- Xu R, "Extracellular vesicle isolation and characterization : toward clinical application", J Clin Invest, 126, pp.1152~1162 (2016)
- Hessvik NP, "Current knowledge on exosome biogenesis and release", Cell Mol Life Sci, 75, pp.193~208 (2018)
- Akers JC, "Biogenesis of extracellular vesicles(EV) : exosomes, microvesicles, retroviruslike vesicles, and apoptotic bodies", J Neurooncol, 113, pp.1~11 (2013)
- Vlachakis D, "Functions, pathophysiology and current insights of exosomal endocrinology(review)", Mol Med Rep, 23, pp.26~ (2021)
- Guay C, "Exosomes as new players in metabolic organ cross-talk", Diabetes Obes Metab, 19(1), pp.137~146 (2017)
- Mulcahy LA, "Routes and mechanisms of extracellular vesicle uptake", J Extracell Vesicles, 3, pp.24641~ (2014)
- Whitham M, "Extracellular vesicles provide a means for tissue crosstalk during exercise", Cell Metab, 27, pp.237~251 (2018)
- Alamri ZZ, "The role of liver in metabolism : an updated review with physiological emphasis", Int J Basic Clin Pharmacol, 7, pp.2271~2276 (2018)
- Hosseini N, "Alcoholic hepatitis : a review", Alcohol Alcohol, 54, pp.408~416 (2019)
- Lewis JR, "Nonalcoholic fatty liver disease : a review and update", Dig Dis Sci, 55, pp.560~578 (2010)
- Itoh N, "Roles of FGFs as paracrine or endocrine signals in liver development, health, and disease", Front Cell Dev Biol, 4, pp.30~ (2016)
- Woo DH, "Direct and indirect contribution of human embryonic stem cellderived hepatocyte-like cells to liver repair in mice", Gastroenterology, 142, pp.602~611 (2012)
- Campana L, "Liver regeneration and inflammation : from fundamental science to clinical applications", Nat Rev Mol Cell Biol, 22, pp.608~624 (2021)
- Royo F, "Transcriptome of extracellular vesicles released by hepatocytes", PLoS One, 8, pp.e68693~ (2013)
- Witek RP, "Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells", Gastroenterology, 136, pp.320~330 (2009)
- Fonsato V, "Human liver stem cell-derived microvesicles inhibit hepatoma growth in SCID mice by delivering antitumor microRNAs", Stem Cells, 30, pp.1985~1998 (2012)
- Conde-Vancells J, "Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes", J Proteome Res, 7, pp.5157~5166 (2008)
- Wan L, "Exosomes from activated hepatic stellate cells contain GLUT1 and PKM2 : a role for exosomes in metabolic switch of liver nonparenchymal cells", FASEB J, 33, pp.8530~8542 (2019)
- Palomo L, "Abundance of cytochromes in hepatic extracellular vesicles is altered by drugs related with drug-induced liver injury", Hepatol Commun, 2, pp.1064~1079 (2018)
- Yuasa T, "Sequential cleavage of insulin receptor by calpain 2 and γ-secretase impairs insulin signalling", Diabetologia, 59, pp.2711~2721 (2016)
- Boucher J, "Insulin receptor signaling in normal and insulin-resistant states", Cold Spring Harb Perspect Biol, 6, pp.a009191~ (2014)
- Rahman MA, "Plasma exosomes exacerbate alcohol-and acetaminopheninduced toxicity via CYP2E1 pathway", Sci Rep, 9, pp.6571~ (2019)
- Fafián-Labora JA, "Small extracellular vesicles have GST activity and ameliorate senescence-related tissue damage", Cell Metab, 32, pp.71~86 (2020)
- Fu Q, "Hepatocytes derived extracellular vesicles from high-fat diet induced obese mice modulate genes expression and proliferation of islet βcells", Biochem Biophys Res Commun, 516, pp.1159~1166 (2019)
- Zhao Y, "Liver governs adipose remodelling via extracellular vesicles in response to lipid overload", Nat Commun, 11, pp.719~ (2020)
- Kobayashi Y, "Circulating extracellular vesicles are associated with lipid and insulin metabolism", Am J Physiol Endocrinol Metab, 315, pp.E574~E582 (2018)
- Wu J, "Hepatic exosomederived miR-130a-3p attenuates glucose intolerance via suppressing PHLPP2 gene in adipocyte", Metabolism, 103, pp.154006~ (2020)
- Yang MQ, "Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia", reperfusion injury, 2018, pp.67, 1056~1070
- Li X, "Cholangiocyte-derived exosomal lncRNA H19 promotes macrophage activation and hepatic inflammation under cholestatic conditions", Cells, 9, pp.190~ (2020)
- Yu Y, "Adipocyte-derived exosomal miR-27a induces insulin resistance in skeletal muscle through repression of PPARγ", Theranostics, 8, pp.2171~2188 (2018)
- Gan L, "Small extracellular microvesicles mediated pathological communications between dysfunctional adipocytes and cardiomyocytes as a novel mechanism exacerbating ischemia", reperfusion injury in diabetic mice, 2020, pp.141, 968~983
- Costa-Silva B, "Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver", Nat Cell Biol, 17, pp.816~826 (2015)
- Verweij FJ, "Live tracking of inter-organ communication by endogenous exosomes in vivo", Dev Cell, 48, pp.573~589 (2019)
- Pardo F, "Extracellular vesicles in obesity and diabetes mellitus", Mol Aspects Med, 60, pp.81~91 (2018)
- Jansen F, "Extracellular vesicles in cardiovascular disease : potential applications in diagnosis, prognosis, and epidemiology", Circ Res, 120, pp.1649~1657 (2017)
- Imai T, "Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice", J Extracell Vesicles, 4, pp.26238~ (2015)
- Bala S, "Biodistribution and function of extracellular miRNA-155in mice", Sci Rep, 5, pp.10721~ (2015)
- Kim OY, "Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response", Nat Commun, 8, pp.626~ (2017)
- Couch Y, "Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation", Sci Rep, 7, pp.9574~ (2017)
- Chen L, "Therapeutic effects of serum extracellular vesicles in liver fibrosis", J Extracell Vesicles, 7, pp.1461505~ (2018)
- Willekens FL, "Liver Kupffer cells rapidly remove red blood cell-derived vesicles from the circulation by scavenger receptors", Blood, 105, pp.2141~2145 (2005)
- Afrisham R, "Effect of circulating exosomes derived from normal-weight and obese women on gluconeogenesis, glycogenesis, lipogenesis and secretion of FGF21 and fetuin A in HepG2 cells", Diabetol Metab Syndr, 12, pp.32~ (2020)
- Su T, "Bone marrow mesenchymal stem cells-derived exosomal MiR-29b-3p regulates aging-associated insulin resistance", ACS Nano, 13, pp.2450~2462 (2019)
- Ying W, "Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity", Cell, 171, pp.372~384 (2017)
- Luo Z, "CRIg+ macrophages prevent gut microbial DNAcontaining extracellular vesicle-induced tissue inflammation and insulin resistance", Gastroenterology, 160, pp.863~874 (2021)
- Deng ZB, "Exosomelike nanoparticles from intestinal mucosal cells carry prostaglandin E2 and suppress activation of liver NKT cells", J Immunol, 190, pp.3579~3589 (2013)
- Kumar S, "Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications", Biochem Biophys Res Commun, 491, pp.675~680 (2017)
- Cho YE, "Increased ethanol-inducible cytochrome P450-2E1 and cytochrome P450 isoforms in exosomes of alcohol-exposed rodents and patients with alcoholism through oxidative and endoplasmic reticulum stress", Hepatol Commun, 1, pp.675~690 (2017)
- Cho YE, "Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice", Sci Rep, 8, pp.16070~ (2018)
- Hardy T, "Nonalcoholic fatty liver disease : pathogenesis and disease spectrum", Annu Rev Pathol, 11, pp.451~496 (2016)
- Povero D, "Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require vanin-1for uptake by endothelial cells", Sci Signal (2013)
- Povero D, "Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease", PLoS One, 9, pp.e113651~ (2014)
- Wu GY, "MicroRNA-122 inhibits lipid droplet formation and hepatic triglyceride accumulation via Yin Yang 1", Cell Physiol Biochem, 44, pp.1651~1664 (2017)
- Liu XL, "miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1", World J Gastroenterol, 23, pp.8140~8151 (2017)
- Geng Y, "How does hepatic lipid accumulation lead to lipotoxicity in nonalcoholic fatty liver disease?", Hepatol Int, 15, pp.21~35 (2021)
- Liu M, "The emerging role of CXCL10 in cancer(review)", Oncol Lett, 2, pp.583~589 (2011)
- Ibrahim SH, "Mixed lineage kinase 3 mediates release of C-XC motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes", Hepatology, 63, pp.731~744 (2016)
- Guo Q, "Integrin β1-enriched extracellular vesicles mediate monocyte adhesion and promote liver inflammation in murine NASH", J Hepatol, 71, pp.1193~1205 (2019)
- Hirsova P, "Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes", Gastroenterology, 150, pp.956~967 (2016)
- Garcia-Martinez I, "Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9", J Clin Invest, 126, pp.859~864 (2016)
- Jiang F, "Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1", J Hepatol, 72, pp.156~166 (2020)
- Kornek M, "Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis", Gastroenterology, 143, pp.448~458 (2012)
- Li J, "Characterization of cellular sources and circulating levels of extracellular vesicles in a dietary murine model of nonalcoholic steatohepatitis", Hepatol Commun, 3, pp.1235~1249 (2019)
- Hwi Young Kim, "Recent advances in nonalcoholic fatty liver disease metabolomics", Clinical and Molecular Hepatology, 27(4), pp.553~559 (2021), 대한간학회[DOI]
- Babuta M, "Dysregulated autophagy and lysosome function are linked to exosome production by micro-RNA 155 in alcoholic liver disease", Hepatology, 70, pp.2123~2141 (2019)
- Eguchi A, "Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice", J Mol Med(Berl), 98, pp.1021~1034 (2020)
- Lee JH, "Mitochondrial double-stranded RNA in exosome promotes interleukin-17 production through toll-like receptor 3 in alcoholassociated liver injury", Hepatology, 72, pp.609~625 (2020)
- Saha B, "MicroRNA cargo of extracellular vesicles from alcohol-exposed monocytes signals naive monocytes to differentiate into M2 macrophages", J Biol Chem, 291, pp.149~159 (2016)
- Momen-Heravi F, "Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS", Sci Rep, 5, pp.9991~ (2015)
- Bala S, "Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases", Hepatology, 56, pp.1946~1957 (2012)
- Cai Y, "Mitochondrial DNA-enriched microparticles promote acute-onchronic alcoholic neutrophilia and hepatotoxicity", JCI Insight, 2, pp.e92634~ (2017)
- Saha B, "Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90", Hepatology, 67, pp.1986~2000 (2018)
- Verma VK, "Alcohol stimulates macrophage activation through caspasedependent hepatocyte derived release of CD40L containing extracellular vesicles", J Hepatol, 64, pp.651~660 (2016)
- Lamas-Paz A, "Intestinal epithelial cell-derived extracellular vesicles modulate hepatic injury via the gut-liver axis during acute alcohol injury", Front Pharmacol, 11, pp.603771~ (2020)
- Ramakrishnaiah V, "Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7. 5 cells", Proc Natl Acad Sci U S A, 110, pp.13109~13113 (2013)
- Yang Y, "Exosomes mediate hepatitis B virus(HBV)transmission and NK-cell dysfunction", Cell Mol Immunol, 14, pp.465~475 (2017)
- Chapuy-Regaud S, "Characterization of the lipid envelope of exosome encapsulated HEV particles protected from the immune response", Biochimie, 141, pp.70~79 (2017)
- Shrivastava S, "Knockdown of autophagy inhibits infectious hepatitis C virus release by the exosomal pathway", J Virol, 90, pp.1387~1396 (2015)
- Harwood NM, "HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production", J Leukoc Biol, 99, pp.495~503 (2016)
- Cobb DA, "Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection", Hepatology, 67, pp.71~85 (2018)
- Kakizaki M, "The immunological function of extracellular vesicles in hepatitis B virus-infected hepatocytes", PLoS One, 13, pp.e0205886~ (2018)
- An SY, "Milk fat globule-egf factor 8, secreted by mesenchymal stem cells, protects against liver fibrosis in mice", Gastroenterology, 152, pp.1174~1186 (2017)
- Naoshi Odagiri, "Anti-fibrotic treatments for chronic liver diseases: The present and the future", Clinical and Molecular Hepatology, 27(3), pp.413~424 (2021), 대한간학회[DOI]
- Povero D, "Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-γ", Cell Mol Gastroenterol Hepatol, 1, pp.646~663 (2015)
- Elpek GÖ, "Angiogenesis and liver fibrosis", World J Hepatol, 7, pp.377~391 (2015)
- Kapoor NR, "The HBx gene of hepatitis B virus can influence hepatic microenvironment via exosomes by transferring its mRNA and protein", Virus Res, 240, pp.166~174 (2017)
- Ying HZ, "PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics(review)", Mol Med Rep, 16, pp.7879~7889 (2017)
- Kostallari E, "Hepatic stellate cell-derived plateletderived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2", Hepatology, 68, pp.333~348 (2018)
- Wang R, "Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate-dependent migration", J Biol Chem, 290, pp.30684~30696 (2015)
- Seo W, "Exosomemediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis", Hepatology, 64, pp.616~631 (2016)
- Koeck ES, "Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes : a novel paradigm for obesity-related liver disease", J Surg Res, 192, pp.268~275 (2014)
- Chen L, "Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells", FASEB J, 34, pp.5178~5192 (2020)
- Benbow JH, "Hepatic stellate cell-derived exosomes modulate macrophage inflammatory response", Exp Cell Res, 405, pp.112663~ (2021)
- Seo W, "ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles", J Hepatol, 71, pp.1000~1011 (2019)
- Wang SC, "Exosome-derived differentiation antagonizing non-protein coding RNA with risk of hepatitis C virus-related hepatocellular carcinoma recurrence", Liver Int, 41, pp.956~968 (2021)
- Wang B, "Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL", 6 mice, 2009, pp.50, 1152~1161
- Zhang Y, "Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling", Hepatology, 56, pp.1631~1640 (2012)
- Niu LJ, "Exosomal microRNA-155 as a biomarker for hepatic fibrosis diagnosis and progression", Ann Transl Med, 9, pp.137~ (2021)
- He M, "Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs", Carcinogenesis, 36, pp.1008~1018 (2015)
- He X, "Exosomes derived from liver cancer cells reprogram biological behaviors of LO2cells by transferring Linc-ROR", Gene, 719, pp.144044~ (2019)
- Cao LQ, "Exosomal miR-21 regulates the TETs", PTENp1, Mol Cancer, pp.2019, 18[DOI]
- Li X, "Regulation of macrophage activation and polarization by HCC-derived exosomal lncRNA TUC339", Int J Mol Sci, 19, pp.2958~ (2018)
- Wang X, "14-3-3ζ delivered by hepatocellular carcinoma-derived exosomes impaired anti-tumor function of tumor-infiltrating T lymphocytes", Cell Death Dis, 9, pp.159~ (2018)
- Zhu AX, "HCC and angiogenesis : possible targets and future directions", Nat Rev Clin Oncol, 8, pp.292~301 (2011)
- Matsuura Y, "Exosomal miR-155 derived from hepatocellular carcinoma cells under hypoxia promotes angiogenesis in endothelial cells", Dig Dis Sci, 64, pp.792~802 (2019)
- Fu X, "Exosomal microRNA-32-5p induces multidrug resistance in hepatocellular carcinoma via the PI3K", Akt pathway, 2018, pp.37, 52~
- Chiba M, "Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines", Oncol Rep, 28, pp.1551~1558 (2012)
- Yan-Chun L, "MicroRNA-192-5p promote the proliferation and metastasis of hepatocellular carcinoma cell by targeting SEMA3A", Appl Immunohistochem Mol Morphol, 25, pp.251~260 (2017)
- Zhang H, "Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7", Oncogene, 38, pp.2844~2859 (2019)
- Wang S, "Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties", J Hematol Oncol, 11, pp.82~ (2018)
- Chen L, "HCC-derived exosomes elicit HCC progression and recurrence by epithelialmesenchymal transition through MAPK", ERK signalling pathway, 2018, pp.9, 513~
- Conigliaro A, "CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA", Mol Cancer, 14, pp.155~ (2015)
- Fang JH, "Hepatoma cell-secreted exosomal microRNA-103 increases vascular permeability and promotes metastasis by targeting junction proteins", Hepatology, 68, pp.1459~1475 (2018)
- Mao X, "Nidogen 1-enriched extracellular vesicles facilitate extrahepatic metastasis of liver cancer by activating pulmonary fibroblasts to secrete tumor necrosis factor receptor 1", Adv Sci(Weinh), 7, pp.2002157~ (2020)
- Nakano T, "Circulating exosomal miR-92b : its role for cancer immunoediting and clinical value for prediction of posttransplant hepatocellular carcinoma recurrence", Am J Transplant, 19, pp.3250~3262 (2019)
- Lee J, "Extracellular vesicles from in vivo liver tissue accelerate recovery of liver necrosis induced by carbon tetrachloride", J Extracell Vesicles, 10, pp.e12133~ (2021)
- He Y, "Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223-enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis", J Clin Invest, 131, pp.e141513~ (2021)
- Dreux M, "Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity", Cell Host Microbe, 12, pp.558~570 (2012)
- Li J, "Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity", Nat Immunol, 14, pp.793~803 (2013)
- Chen L, "Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression : role of exosomes in horizontal transfer of Twist1", Am J Physiol Gastrointest Liver Physiol, 309, pp.G491~G499 (2015)
- Kornek M, "Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells", Hepatology, 53, pp.230~242 (2011)
- Rao Q, "Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro", Hepatology, 64, pp.456~472 (2016)
- Lu Z, "Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models", J Hepatol, 67, pp.739~748 (2017)
- Lv LH, "Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro", J Biol Chem, 287, pp.15874~15885 (2012)
- Yoshida M, "Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice", Cell Metab, 30, pp.329~342 (2019)
- Hur YH, "Embryonic stem cell-derived extracellular vesicles maintain ESC stemness by activating FAK", Dev Cell, 56, pp.277~291 (2021)
- Dasgupta D, "IRE1A stimulates hepatocyte-derived extracellular vesicles that promote inflammation in mice with steatohepatitis", Gastroenterology, 159, pp.1487~1503 (2020)
- Johnsen KB, "A comprehensive overview of exosomes as drug delivery vehicles-endogenous nanocarriers for targeted cancer therapy", Biochim Biophys Acta, 1846, pp.75~87 (2014)
- Bruno S, "HLSC-derived extracellular vesicles attenuate liver fibrosis and inflammation in a murine model of nonalcoholic steatohepatitis", Mol Ther, 28, pp.479~489 (2020)
- Yusuke Watanabe, "The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future", Clinical and Molecular Hepatology, 27(1), pp.70~80 (2021), 대한간학회[DOI]
- Kim J, "sEVs from tonsil-derived mesenchymal stromal cells alleviate activation of hepatic stellate cells and liver fibrosis through miR-486-5p", Mol Ther, 29, pp.1471~1486 (2021)
- Mardpour S, "Hydrogel-mediated sustained systemic delivery of mesenchymal stem cell-derived extracellular vesicles improves hepatic regeneration in chronic liver failure", ACS Appl Mater Interfaces, 11, pp.37421~37433 (2019)
- Fiore E, "Human umbilical cord perivascular cellsderived extracellular vesicles mediate the transfer of IGF-I to the liver and ameliorate hepatic fibrogenesis in mice", Gene Ther, 27, pp.62~73 (2020)
- Anticoli S, "Engineered exosomes boost the HCV NS3-specific CD8+ T lymphocyte immunity in humans", Trials in Vaccinol, 5, pp.105~110 (2016)
- nMatsuda A, "Extracellular vesiclebased therapeutic targeting of β-catenin to modulate anticancer immune responses in hepatocellular cancer", Hepatol Commun, 3, pp.525~541 (2019)
- Momen-Heravi F, "Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages", Nanomedicine, 10, pp.1517~1527 (2014)
- Luo N, "Hepatic stellate cell reprogramming via exosome-mediated CRISPR", dCas9-VP64delivery, 2021, pp.28, 10~18
- Liang L, "Treatment for hepatocellular carcinoma is enhanced when norcantharidin is encapsulated in exosomes derived from bone marrow mesenchymal stem cells", Mol Pharm, 18, pp.1003~1013 (2021)
