본문 바로가기
KERD
논문KCI 등재

Aging

1

조회

0

다운로드

2

인용

0

참고문헌

초록

Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression onto pathological aging. Despite the efforts from many researchers, the progression and the mechanisms of aging are not clearly understood yet. Therefore, the authors would like to introduce several theories which have gained attentions among the published theories up to date; genetic program theory, wear-and-tear theory, telomere theory, endocrine theory, DNA damage hypothesis, error catastrophe theory, the rate of living theory, mitochondrial theory, and free radical theory. Although there have been many studies that have tried to prevent aging and prolong life, here we introduce a couple of theories which have been proven more or less; food, exercise, and diet restriction.

Abstract

Aging is initiated based on genetic and environmental factors that operate from the time of birth of organisms. Aging induces physiological phenomena such as reduction of cell counts, deterioration of tissue proteins, tissue atrophy, a decrease of the metabolic rate, reduction of body fluids, and calcium metabolism abnormalities, with final progression onto pathological aging. Despite the efforts from many researchers, the progression and the mechanisms of aging are not clearly understood yet. Therefore, the authors would like to introduce several theories which have gained attentions among the published theories up to date; genetic program theory, wear-and-tear theory, telomere theory, endocrine theory, DNA damage hypothesis, error catastrophe theory, the rate of living theory, mitochondrial theory, and free radical theory. Although there have been many studies that have tried to prevent aging and prolong life, here we introduce a couple of theories which have been proven more or less; food, exercise, and diet restriction.

참고문헌 (23)

  1. Harman D, "The aging process", Proc Natl Acad Sci U S A, 78, pp.7124~7128 (1981)
  2. Albert MA, "Diseases of the Nervous System-Clinical Neurobiology", pp.598~611 (1992), WB Saunders
  3. Park SS., "Characteristics of Aging: Anatomical changes. Geriatrics", pp.7~13 (1997), Seoul National University Press
  4. Kin J., "Characteristics of Aging: Functional changes. Geriatrics", pp.14~26 (1997), Seoul National University Press
  5. Brizzee KR., "Relations between Normal aging and Disease", pp.191~224 (1985), Raven Press
  6. Kohn RR, "Relations between Normal Aging and Disease", pp.1~44 (1985), Raven Press
  7. Evers BM, "Organ physiology of aging", Surg Clin North Am, 74, pp.23~39 (1994)
  8. Resnick NM, "Principle of Internal Medicine", pp.31~38 (1994), WB Saunders
  9. Arking R., "The Biology of Aging: Observarion and principles", pp.153~250 (1998), Sinauer Associates Inc
  10. Troen BR, "The biology of aging", Mt Sinai J Med, 70, pp.3~22 (2003)
  11. Hasty P, "Genomic priorities in aging", Science, 296, pp.1250~1251 (2002)
  12. Wong JM, "Telomere maintenance and disease", Lancet, 362, pp.983~988 (2003)
  13. Tatar M, "The endocrine regulation of aging by insulin-like signals", Science, 299, pp.1346~1351 (2003)
  14. Bohr VA, "DNA damage, mutation and fine structure DNA repair in aging", Mutat Res, 338, pp.25~34 (1995)
  15. Weinert BT, "Invited review : theories of aging", J Appl Physiol, 95, pp.1706~1716 (2003)
  16. Trifunovic A, "Premature ageing in mice expressing defective mitochondrial DNA polymerase", Nature, 429, pp.417~423 (2004)
  17. Balaban RS, "Mitochondria, oxidants, and aging", Cell, 120, pp.483~495 (2005)
  18. Beckman KB, "The free radical theory of aging matures", Physiol Rev, 78, pp.547~581 (1998)
  19. Croteau DL, "Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells", J Biol Chem, 272, pp.25409~25412 (1997)
  20. Kim CI., "Treatment: Nutirtion alimentotherapy. Geriatrics", pp.122~131 (1997), Seoul National University Press
  21. DeBoer S, "Diet Manual", pp.58~70 (1994), Mosby
  22. Yu BP, "Life span study of SPF Fischer 344 male rats fed ad libitum or restricted diets: longevity, growth, lean body mass and disease", J Gerontol, 37, pp.130~141 (1982)
  23. Yamaza H, "Lifespan extension by caloric restriction : an aspect of energy metabolism", Microsc Res Tech, 59, pp.325~330 (2002)

관련 논문AI추천

이 간행물의 다른 논문 (11건)