Sequential Involvement of Distinct Portions of the Medial Prefrontal Cortex in Different Stages of Decision Making Using the Iowa Gambling Task
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Functional magnetic resonance imaging (fMRI) was used to assess the temporal response of neural activation in healthy subjects while they performed the Iowa Gambling Test (IGT), which utilizes decisions involving ambiguity and risk. The IGT was divided into five blocks of 20 trials; analysis showed that activity in the medial prefrontal cortex (mPFC) moves gradually from the dorsal to the ventral mPFC over the course of the IGT. These findings suggest that cognitive division of the mPFC, including the dorsal portion of the anterior cingulated cortex (ACC), plays a major role in ambiguous decision making and that the aspect of the IGT corresponding to risky decision making is associated with significant activity within the corticolimbic network strongly implicated in emotion and reinforcement. Our results also suggest that decisions made under ambiguity and decisions made under risk situations can be further divided into sub-phases based on the neural network involved.
Abstract
Functional magnetic resonance imaging (fMRI) was used to assess the temporal response of neural activation in healthy subjects while they performed the Iowa Gambling Test (IGT), which utilizes decisions involving ambiguity and risk. The IGT was divided into five blocks of 20 trials; analysis showed that activity in the medial prefrontal cortex (mPFC) moves gradually from the dorsal to the ventral mPFC over the course of the IGT. These findings suggest that cognitive division of the mPFC, including the dorsal portion of the anterior cingulated cortex (ACC), plays a major role in ambiguous decision making and that the aspect of the IGT corresponding to risky decision making is associated with significant activity within the corticolimbic network strongly implicated in emotion and reinforcement. Our results also suggest that decisions made under ambiguity and decisions made under risk situations can be further divided into sub-phases based on the neural network involved.
참고문헌 (30)
- Adinoff B, "Resting regional cerebral blood flow and gambling task performance in cocainedependent subjects and healthy comparison subjects", Am J Psychiatry, 160, pp.1892~1894 (2003)
- Akitsuki Y, "Context-dependent cortical activation in response to financial reward and penalty: an event-related fMRI study", Neuroimage, 19, pp.1674~1685 (2003)
- Barry D, "Predictors of decision-making on the Iowa Gambling Task: Independent effects of lifetime history of substance use disorders and performance on the Trail Making Test", Brain and Cognition, 66, pp.243~252 (2008)
- Bechara A, "The role of emotion in decision-making: evidence from neurological patients with orbitofrontal damage", Brain and Cognition, 55, pp.30~40 (2004)
- Bechara A, "Insensitivity to future consequences following damage to human prefrontal cortex", Cognition, 50, pp.7~15 (1994)
- Bechara A, "Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers", Neuropsychologia, 39, pp.376~389 (2001)
- Bolla KI, "Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task", NeuroImage, 19, pp.1085~1094 (2003)
- Bush G, "The counting Stroop: an interference task specialized for functional neuroimaging - validation study with functional MRI", Hum. Brain Mapp, 6, pp.270~282 (1998)
- Cavedini P, "Frontal lobe dysfunction in pathological gambling patients", Biol Psychiatry, 51, pp.334~341 (2002)
- Clark L, "The contributions of lesion laterality and lesion volume to decisionmaking impairment following frontal lobe damage", Neuropsychologia, 41, pp.1474~1483 (2003)
- Damasio AR, "Subcortical and cortical brain activity during the feeling of self-generated emotions", Nat Neurosci, 3, pp.1049~1056 (2000)
- Devinsky O, "Contributions of anterior cingulate cortex to behaviour", Brain, 118, pp.279~306 (1995)
- Drevets WC, "Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: implications for interactions between emotion and cognition", Cognition Emotion, 12, pp.353~385 (1998)
- Ventromedial prefrontal cortex mediates guessing, "Ventromedial prefrontal cortex mediates guessing", Neuropsychologia, 37, pp.403~411 (1999)
- Ernst M, "Neurobiology of decision making: a selective review from a neurocognitive and clinical perspective", Biol. Psychiatry, 58, pp.597~604 (2005)
- Ernst M, "Decisionmaking in a risk-taking task: a PET study", Neuropsychopharmacology, 26, pp.682~691 (2002)
- Evans AC, "3D statistical neuroanatomical models from 305 MRI volumes", IEEE-Nucl. Sci. Symp. Med. Imaging, pp.1813~1817 (1993)
- Friston KJ, "Statistical parametric paps in functional imaging: a general linear approach", Hum Brain Mapp, 2, pp.189~210 (1995)
- Fukui H, "Functional activity related to risk anticipation during performance of the Iowa gambling task", NeuroImage, 24, pp.253~259 (2007)
- Hornak J, "Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices", Brain, 126, pp.1691~1712 (2003)
- Koski L, "Functional connectivity of the anterior cingulated cortex within the human frontal lobe: A brainmapping meta-analysis", Exp Brain Res, 133, pp.55~65 (2000)
- Manes F, "Decision-making processes following damage to the prefrontal cortex", Brain, 125, pp.624~639 (2002)
- McGonigle DJ, "Variability in fMRI: an examination of intersession differences", Neuroimage, 11, pp.708~734 (2000)
- Northoff G, "Reciprocal modulation and attenuation in the prefrontal cortex: an fMRI study on emotionalcognitive interaction", Hum Brain Mapp, 21, pp.202~212 (2004)
- Patterson JC, "Taskindependent functional brain activity correlation with skin conductance changes: an fMRI study", Neuroimage, 17, pp.1797~1806 (2002)
- Paus T, "Regional differences in the effects of task difficulty and motor output on blood flow response in the human anterior cingulate cortex: a review of 107 PET activation studies", Neuroreport, 9, pp.R37~R47 (1998)
- Rogers RD, "Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition", Biol Psychiatry, 55, pp.594~602 (2004)
- .Sanfey AG, "Phineas gauged: decision-making and the human prefrontal cortex", Neuropsychologia, 41, pp.1218~1229 (2003)
- , 1999, S36~
- Tranel D, "Asymmetric functionalroles of right and left ventromedial prefrontal cortices in social conduct, decision-making, and emotional processing", Cortex, 38, pp.589~612 (2002)