An MRI-Based Quantification for Correlation of Imaging Biomarker and Clinical Performance in Chronic Phase of Carbon Monoxide Poisoning
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Purpose: The purpose of this study was to determine the relation between quantitative magnetic resonance imaging biomarkers, and clinical performances in chronic phase of carbon monoxide intoxication. Materials and Methods: Eighteen magnetic resonance scans and cognitive evaluations were performed, on patients with carbon monoxide intoxication in chronic phase. Apparent diffusion coefficient (ADC) ratios of affected versus unaffected centrum semiovale, and corpus callosum were obtained. Signal intensity (SI) ratios between affected centrum semiovale, and normal pons in T2-FLAIR (fluidattenuated inversion recovery) images were obtained. The Mini-Mental State Exam, and clinical outcome scores were assessed. Correlation coefficients were calculated, between MRI and clinical markers. Patients were further classified into poor-outcome and good-outcome groups based on clinical performance, and imaging parameters were compared. T2-SI ratio of centrum semiovale was compared, with that of 18 sexmatched and age-matched controls. Results: T2-SI ratio of centrum semiovale was significantly higher in the pooroutcome group, than that in the good-outcome group and was strongly inversely correlated, with results from the Mini-Mental State Exam. ADC ratios of centrum semiovale were significantly lower in the poor outcome group than in the good outcome group, and were moderately correlated with the Mini-Mental State Exam score. Conclusion: A higher T2-SI and a lower ratio of ADC values in the centrum semiovale, may indicate presence of more severe white matter injury and clinical impairment. T2-SI ratio and ADC values in the centrum semiovale, are useful quantitative imaging biomarkers for correlation with clinical performance in individuals with carbon monoxide intoxication.
Abstract
Purpose: The purpose of this study was to determine the relation between quantitative magnetic resonance imaging biomarkers, and clinical performances in chronic phase of carbon monoxide intoxication. Materials and Methods: Eighteen magnetic resonance scans and cognitive evaluations were performed, on patients with carbon monoxide intoxication in chronic phase. Apparent diffusion coefficient (ADC) ratios of affected versus unaffected centrum semiovale, and corpus callosum were obtained. Signal intensity (SI) ratios between affected centrum semiovale, and normal pons in T2-FLAIR (fluidattenuated inversion recovery) images were obtained. The Mini-Mental State Exam, and clinical outcome scores were assessed. Correlation coefficients were calculated, between MRI and clinical markers. Patients were further classified into poor-outcome and good-outcome groups based on clinical performance, and imaging parameters were compared. T2-SI ratio of centrum semiovale was compared, with that of 18 sexmatched and age-matched controls. Results: T2-SI ratio of centrum semiovale was significantly higher in the pooroutcome group, than that in the good-outcome group and was strongly inversely correlated, with results from the Mini-Mental State Exam. ADC ratios of centrum semiovale were significantly lower in the poor outcome group than in the good outcome group, and were moderately correlated with the Mini-Mental State Exam score. Conclusion: A higher T2-SI and a lower ratio of ADC values in the centrum semiovale, may indicate presence of more severe white matter injury and clinical impairment. T2-SI ratio and ADC values in the centrum semiovale, are useful quantitative imaging biomarkers for correlation with clinical performance in individuals with carbon monoxide intoxication.
참고문헌 (27)
- Hampson NB, "Carbon monoxide poisoning: a new incidence for an old disease", Undersea Hyperb Med, 34, pp.163~168 (2007)
- Weaver LK, "Clinical practice. Carbon monoxide poisoning", N Engl J Med, 360, pp.1217~1225 (2009)
- Ernst A, "Carbon monoxide poisoning", N Engl J Med, 339, pp.1603~1608 (1998)
- Beppu T, "The role of MR imaging in assessment of brain damage from carbon monoxide poisoning: a review of the literature", AJNR Am J Neuroradiol, 35, pp.625~631 (2014)
- Kim JH, "Delayed encephalopathy of acute carbon monoxide intoxication: diffusivity of cerebral white matter lesions", AJNR Am J Neuroradiol, 24, pp.1592~1597 (2003)
- Kinoshita T, "Pallidoreticular damage in acute carbon monoxide poisoning: diffusion-weighted MR imaging findings", AJNR Am J Neuroradiol, 26, pp.1845~1848 (2005)
- Ginsberg MD, "Carbon monoxide intoxication: clinical features, neuropathology and mechanisms of injury", J Toxicol Clin Toxicol, 23, pp.281~288 (1985)
- Lapresle J, "The central nervous system and carbon monoxide poisoning. II. Anatomical study of brain lesions following intoxication with carbon monixide (22cases)", Prog Brain Res, 24, pp.31~74 (1967)
- Chen NC, "Diffusion-weighted imaging improves prediction in cognitive outcome and clinical phases in patients with carbon monoxide intoxication", Neuroradiology, 55, pp.107~115 (2013)
- Chang CC, "Damage of white matter tract correlated with neuropsychological deficits in carbon monoxide intoxication after hyperbaric oxygen therapy", J Neurotrauma, 26, pp.1263~1270 (2009)
- McKinney AM, "Acute toxic leukoencephalopathy: potential for reversibility clinically and on MRI with diffusion-weighted and FLAIR imaging", AJR Am J Roentgenol, 193, pp.192~206 (2009)
- Gale SD, "MRI, quantitative MRI, SPECT, and neuropsychological findings following carbon monoxide poisoning", Brain Inj, 13, pp.229~243 (1999)
- Parkinson RB, "White matter hyperintensities and neuropsychological outcome following carbon monoxide poisoning", Neurology, 58, pp.1525~1532 (2002)
- Takaoka M, "Semiquantitative analysis of corpus callosum injury using magnetic resonance imaging indicates clinical severity in patients with diffuse axonal injury", J Neurol Neurosurg Psychiatry, 73, pp.289~293 (2002)
- Varella PP, "Relationship between fluid-attenuated inversion-recovery (FLAIR)signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis", Arq Neuropsiquiatr, 69, pp.91~99 (2011)
- Kang Y, "Two-dimensional speckle tracking echocardiography combined with high-sensitive cardiac troponin T in early detection and prediction of cardiotoxicity during epirubicine-based chemotherapy", Eur J Heart Fail, 16, pp.300~308 (2014)
- Jain KK, "Textbook of hyperbaric medicine", pp.111~133 (2009), Hogrefe Publishing
- Porter SS, "Corpus callosum atrophy and neuropsychological outcome following carbon monoxide poisoning", Arch Clin Neuropsychol, 17, pp.195~204 (2002)
- Lo CP, "Brain injury after acute carbon monoxide poisoning: early and late complications", AJR Am J Roentgenol, 189, pp.W205~W211 (2007)
- Vieregge P, "Carbon monoxide poisoning: clinical, neurophysiological, and brain imaging observations in acute disease and follow-up", J Neurol, 236, pp.478~481 (1989)
- Pracyk JB, "Brain computerized tomography after hyperbaric oxygen therapy for carbon monoxide poisoning", Undersea Hyperb Med, 22, pp.1~7 (1995)
- Sener RN, "Acute carbon monoxide poisoning: diffusion MR imaging findings", AJNR Am J Neuroradiol, 24, pp.1475~1477 (2003)
- Murata T, "Neuronal damage in the interval form of CO poisoning determined by serial diffusion weighted magnetic resonance imaging plus 1H-magnetic resonance spectroscopy", J Neurol Neurosurg Psychiatry, 71, pp.250~253 (2001)
- Pierpaoli C, "Histopathologic correlates of abnormal water diffusion in cerebral ischemia: diffusion-weighted MR imaging and light and electron microscopic study", Radiology, 189, pp.439~448 (1993)
- Beppu T, "Fractional anisotropy in the centrum semiovale as a quantitative indicator of cerebral white matter damage in the subacute phase in patients with carbon monoxide poisoning:correlation with the concentration of myelin basic protein in cerebrospinal fluid", J Neurol, 259, pp.1698~1705 (2012)
- Fujiwara S, "Detecting damaged regions of cerebral white matter in the subacute phase after carbon monoxide poisoning using voxel-based analysis with diffusion tensor imaging", Neuroradiology, 54, pp.681~689 (2012)
- Pandya DN, "The topographical distribution of interhemispheric projections in the corpus callosum of the rhesus monkey", Brain Res, 32, pp.31~43 (1971)