Regional MRI Diffusion, White-Matter Hyperintensities, and Cognitive Function in Alzheimer’s Disease and Vascular Dementia
2
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background and Purpose An increase in brain water diffusivity as measured using magnetic resonance imaging (MRI) has been recently reported in normal-appearing white matter (NAWM) in patients affected by cognitive impairment. However, it remains to be clarified if this reflects an overt neuronal tissue disruption that leads to degenerative or microvascular lesions. This question was addressed by comparing the regional MRI apparent diffusion coefficients (ADCs) of NAWM in patients affected by Alzheimer’s disease (AD) or vascular dementia (VaD). The relationships of ADCs with the white-matter hyperintensity (WMH) burden, carotid atherosclerosis, and cognitive performance were also investigated. Methods Forty-nine AD and 31 VaD patients underwent brain MRI to assess the WMH volume and regional NAWM ADCs, neuropsychological evaluations, and carotid ultrasound to assess the plaque severity and intima-media thickness (IMT). Results Regional ADCs in NAWM did not differ between VaD and AD patients, while the WMH volume was greater in VaD than in AD patients. The ADC in the anterior corpus callosum was related to the WMH volume, while a greater carotid IMT was positively correlated with the temporal ADC and WMH volume. The memory performance was worse in patients with higher temporal ADCs. Constructional praxis scores were related to ADCs in the frontal, and occipital lobes, in the anterior and posterior corpus callosum as well as to the WMH volume. Abstract reasoning was related to frontal, parietal, and temporal ADCs. Conclusions Our data show that higher regional ADCs in NAWM are associated with microcirculatory impairment, as depicted by the WMH volume. Moreover, regional ADCs in NAWM are differently associated with the neuropsychological performances in memory, constructional praxia, and abstract reasoning domains.
Abstract
Background and Purpose An increase in brain water diffusivity as measured using magnetic resonance imaging (MRI) has been recently reported in normal-appearing white matter (NAWM) in patients affected by cognitive impairment. However, it remains to be clarified if this reflects an overt neuronal tissue disruption that leads to degenerative or microvascular lesions. This question was addressed by comparing the regional MRI apparent diffusion coefficients (ADCs) of NAWM in patients affected by Alzheimer’s disease (AD) or vascular dementia (VaD). The relationships of ADCs with the white-matter hyperintensity (WMH) burden, carotid atherosclerosis, and cognitive performance were also investigated. Methods Forty-nine AD and 31 VaD patients underwent brain MRI to assess the WMH volume and regional NAWM ADCs, neuropsychological evaluations, and carotid ultrasound to assess the plaque severity and intima-media thickness (IMT). Results Regional ADCs in NAWM did not differ between VaD and AD patients, while the WMH volume was greater in VaD than in AD patients. The ADC in the anterior corpus callosum was related to the WMH volume, while a greater carotid IMT was positively correlated with the temporal ADC and WMH volume. The memory performance was worse in patients with higher temporal ADCs. Constructional praxis scores were related to ADCs in the frontal, and occipital lobes, in the anterior and posterior corpus callosum as well as to the WMH volume. Abstract reasoning was related to frontal, parietal, and temporal ADCs. Conclusions Our data show that higher regional ADCs in NAWM are associated with microcirculatory impairment, as depicted by the WMH volume. Moreover, regional ADCs in NAWM are differently associated with the neuropsychological performances in memory, constructional praxia, and abstract reasoning domains.
참고문헌 (46)
- Viticchi G, "Vascular predictors of cognitive decline in patients with mild cognitive impairment", Neurobiol Aging, 33, pp.1127.e1~1127.e9 (2012)
- Iadecola C, "The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia", Acta Neuropathol, 120, pp.287~296 (2010)
- van Oijen M, "Atherosclerosis and risk for dementia", Ann Neurol, 61, pp.403~410 (2007)
- Altamura C, "What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia?", Eur J Neurol, 14, pp.679~682 (2007)
- de la Torre JC, "The vascular hypothesis of Alzheimer’s disease: bench to bedside and beyond", Neurodegener Dis, 7, pp.116~121 (2010)
- Buratti L, "Markers for the risk of progression from mild cognitive impairment to Alzheimer’s disease", J Alzheimers Dis, 45, pp.883~890 (2015)
- de la Torre JC, "Carotid artery ultrasound and echocardiography testing to lower the prevalence of Alzheimer’s disease", J Stroke Cerebrovasc Dis, 18, pp.319~328 (2009)
- Marshall RS, "Pumps, aqueducts, and drought management:vascular physiology in vascular cognitive impairment", Stroke, 42, pp.221~226 (2011)
- O’Sullivan M, "Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis", J Neurol Neurosurg Psychiatry, 75, pp.441~447 (2004)
- Shenkin SD, "Cognitive correlates of cerebral white matter lesions and water diffusion tensor parameters in community-dwelling older people", Cerebrovasc Dis, 20, pp.310~318 (2005)
- Della Nave R, "Whole-brain histogram and voxel-based analyses of diffusion tensor imaging in patients with leukoaraiosis: correlation with motor and cognitive impairment", AJNR Am J Neuroradiol, 28, pp.1313~1319 (2007)
- Nitkunan A, "Multimodal MRI in cerebral small vessel disease: its relationship with cognition and sensitivity to change over time", Stroke, 39, pp.1999~2005 (2008)
- Viana-Baptista M, "Cognitive function correlates with frontal white matter apparent diffusion coefficients in patients with leukoaraiosis", J Neurol, 255, pp.360~366 (2008)
- Wang L, "White matter hyperintensities and changes in white matter integrity in patients with Alzheimer’s disease", Neuroradiology, 53, pp.373~381 (2011)
- Lee DY, "Regional pattern of white matter microstructural changes in normal aging, MCI, and AD", Neurology, 73, pp.1722~1728 (2009)
- Gouw AA, "Heterogeneity of white matter hyperintensities in Alzheimer’s disease: post-mortem quantitative MRI and neuropathology", Brain, 131(Pt 12), pp.3286~3298 (2008)
- Alves GS, "Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients", PLoS One, 7, pp.e52859~ (2012)
- Stahl R, "White matter damage in Alzheimer disease and mild cognitive impairment:assessment with diffusion-tensor MR imaging and parallel imaging techniques", Radiology, 243, pp.483~492 (2007)
- Kantarci K, "Mild cognitive impairment and Alzheimer disease: regional diffusivity of water", Radiology, 219, pp.101~107 (2001)
- Agosta F, "White matter damage in Alzheimer disease and its relationship to gray matter atrophy", Radiology, 258, pp.853~863 (2011)
- Kantarci K, "DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment", Neurology, 64, pp.902~904 (2005)
- Staekenborg SS, "Progression of mild cognitive impairment to dementia:contribution of cerebrovascular disease compared with medial temporal lobe atrophy", Stroke, 40, pp.1269~1274 (2009)
- Schmidt R, "Diffusion-weighted imaging and cognition in the leukoariosis and disability in the elderly study", Stroke, 41, pp.e402~e408 (2010)
- Maillard P, "FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities", AJNR Am J Neuroradiol, 34, pp.54~61 (2013)
- de Groot M, "Changes in normal-appearing white matter precede development of white matter lesions", Stroke, 44, pp.1037~1042 (2013)
- Conklin J, "Mapping white matter diffusion and cerebrovascular reactivity in carotid occlusive disease", Neurology, 77, pp.431~438 (2011)
- Rentsch-Granges V, "ADC mapping of chronic cerebral hypoperfusion induced by carotid artery stenosis", J Neuroradiol, 38, pp.232~237 (2011)
- Soinne L, "Brain diffusion changes in carotid occlusive disease treated with endarterectomy", Neurology, 61, pp.1061~1065 (2003)
- Sahin N, "Brain diffusion changes in unilateral carotid artery stenosis with non-shunt endarterectomy: correlation with white matter lesions", Clin Neurol Neurosurg, 133, pp.24~29 (2015)
- Dubois B, "Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria", Lancet Neurol, 6, pp.734~746 (2007)
- Román GC, "Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop", Neurology, 43, pp.250~260 (1993)
- van Straaten EC, "Operational definitions for the NINDS-AIREN criteria for vascular dementia: an interobserver study", Stroke, 34, pp.1907~1912 (2003)
- Grigoletto F, "Norms for the Mini-Mental State Examination in a healthy population", Neurology, 53, pp.315~320 (1999)
- Miceli G, "Batteria per l’Analisi dei Deficit Afasici (B.A.D.A.)" (1994), CEPSAG, Università Cattolica del Sacro Cuore
- Spinnler H, "Standardizzazione e taratura italiana dei test neuropsicologici", Ital J Neurol Sci, 78-80, pp.97~99 (1987)
- Lezak MD, "Neuropsychological assessment" (2004), Oxford University Press
- Rosset A, "OsiriX: an open-source software for navigating in multidimensional DICOM images", J Digit Imaging, 17, pp.205~216 (2004)
- Stejskal E, "Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient", J Chem Phys, 42, pp.288~292 (1965)
- Touboul PJ, "Mannheim carotid intima-media thickness consensus (2004-2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006", Cerebrovasc Dis, 23, pp.75~80 (2007)
- Kantarci K, "Diffusion tensor imaging and cognitive function in older adults with no dementia", Neurology, 77, pp.26~34 (2011)
- Back SA, "White matter lesions defined by diffusion tensor imaging in older adults", Ann Neurol, 70, pp.465~476 (2011)
- Pievani M, "Assessment of white matter tract damage in mild cognitive impairment and Alzheimer’s disease", Hum Brain Mapp, 31, pp.1862~1875 (2010)
- Lee DY, "Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer disease", Stroke, 41, pp.1791~1797 (2010)
- Gootjes L, "Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer’s disease and healthy aging", Dement Geriatr Cogn Disord, 18, pp.180~188 (2004)
- Kim HJ, "Clinical effect of white matter network disruption related to amyloid and small vessel disease", Neurology, 85, pp.63~70 (2015)
- Acosta-Cabronero J, "Diffusion tensor metrics as biomarkers in Alzheimer’s disease", PLoS One, 7, pp.e49072~ (2012)