First-pass Stress Perfusion MR Imaging Findings of Apical Hypertrophic ardiomyopathy: with Relation to LV Wall Thickness and Late Gadolinium-enhancement
First-pass Stress Perfusion MR Imaging Findings of Apical Hypertrophic Cardiomyopathy: with Relation to LV Wall Thickness and Late Gadolinium-enhancement
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Purpose : To evaluate the prevalence and pattern of perfusion defect (PD) on first-pass stress perfusion MR imaging inrelation with the degree of left ventricular hypertrophy (LVH) and late gadolinium-enhancement (LGE) in patients with apicalhypertrophic cardiomyopathy (APH). Materials and Methods: Cardiac MR imaging with first-pass stress perfusion, cine, and LGE sequence was performed in26 patients with APH from January 2008 to December 2012. We analyzed a total of 416 segments for LV wall thicknesson end-diastolic phase of cine images, and evaluated the number of hypertrophied segment and number of consecutivehypertrophied segment (NCH). We assessed the presence or absence of PD and LGE from all patients. If there was PD, wesubdivided the pattern into sporadic (sporadic-PD) or ring (ring-PD). Using univariate logistic method, we obtained theindependent predictor for presence of overall PD and ring-PD. Results: PD on stress perfusion MRI was observed in 20 patients (76.9%), 12 of them (60%) showed ring-PD. Maximal LVwall thickness and number of hypertrophied segment were independent predictors for overall PD (all, p < 0.05). NCH withmore than 3 segments was an additional independent factor for ring-PD. However, LGE was not statistically related withPD in patients with APH. Conclusion: About three quarters of the patients with APH showed PD, most of them represented as ring-PD. LVH degreeor distribution was related with pattern of PD, however, LGE was not related with PD. Therefore, the clinical significanceof PD in the patients with APH seems to be different from those with non-APH, and further comparison study betweenthe two groups should be carried out.
Abstract
Purpose : To evaluate the prevalence and pattern of perfusion defect (PD) on first-pass stress perfusion MR imaging inrelation with the degree of left ventricular hypertrophy (LVH) and late gadolinium-enhancement (LGE) in patients with apicalhypertrophic cardiomyopathy (APH). Materials and Methods: Cardiac MR imaging with first-pass stress perfusion, cine, and LGE sequence was performed in26 patients with APH from January 2008 to December 2012. We analyzed a total of 416 segments for LV wall thicknesson end-diastolic phase of cine images, and evaluated the number of hypertrophied segment and number of consecutivehypertrophied segment (NCH). We assessed the presence or absence of PD and LGE from all patients. If there was PD, wesubdivided the pattern into sporadic (sporadic-PD) or ring (ring-PD). Using univariate logistic method, we obtained theindependent predictor for presence of overall PD and ring-PD. Results: PD on stress perfusion MRI was observed in 20 patients (76.9%), 12 of them (60%) showed ring-PD. Maximal LVwall thickness and number of hypertrophied segment were independent predictors for overall PD (all, p < 0.05). NCH withmore than 3 segments was an additional independent factor for ring-PD. However, LGE was not statistically related withPD in patients with APH. Conclusion: About three quarters of the patients with APH showed PD, most of them represented as ring-PD. LVH degreeor distribution was related with pattern of PD, however, LGE was not related with PD. Therefore, the clinical significanceof PD in the patients with APH seems to be different from those with non-APH, and further comparison study betweenthe two groups should be carried out.
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