Quantification of Gadolinium Concentration Using GRE and UTE Sequences
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Purpose: To compare different MR sequences for quantification of gadolinium concentration. Materials and Methods: Gadolinium contrast agents were diluted into 36 different concentrations. They were scanned using gradient echo (GRE) and ultrashort echo time (UTE) and R1, R2* and phase values were estimated from collected data. For analysis, ROI masks were made for each concentration and then ROI value was measured by mean and standard deviation from the estimated quantitative maps. Correlation analysis was performed and correlation coefficient was calculated. Results: Using GRE sequence, R1 showed a strong linear correlation at concentrations of 10 mM or less, and R2* showed a strong linear correlation between 10 to 100 mM. The phase of GRE generally exhibited a negative linear relationship for concentrations of 100 mM or less. In the case of UTE, the phase had a strong negative linear relationship at concentrations 100 mM or above. Conclusion: R1, which was calculated by conventional GRE, showed a high performance of quantification for lower concentrations, with a correlation coefficient of 0.966 (10 mM or less). R2* showed stronger potential for higher concentrations with a correlation coefficient of 0.984 (10 to 100 mM), and UTE phase showed potential for even higher concentrations with a correlation coefficient of 0.992 (100 mM or above).
Abstract
Purpose: To compare different MR sequences for quantification of gadolinium concentration. Materials and Methods: Gadolinium contrast agents were diluted into 36 different concentrations. They were scanned using gradient echo (GRE) and ultrashort echo time (UTE) and R1, R2* and phase values were estimated from collected data. For analysis, ROI masks were made for each concentration and then ROI value was measured by mean and standard deviation from the estimated quantitative maps. Correlation analysis was performed and correlation coefficient was calculated. Results: Using GRE sequence, R1 showed a strong linear correlation at concentrations of 10 mM or less, and R2* showed a strong linear correlation between 10 to 100 mM. The phase of GRE generally exhibited a negative linear relationship for concentrations of 100 mM or less. In the case of UTE, the phase had a strong negative linear relationship at concentrations 100 mM or above. Conclusion: R1, which was calculated by conventional GRE, showed a high performance of quantification for lower concentrations, with a correlation coefficient of 0.966 (10 mM or less). R2* showed stronger potential for higher concentrations with a correlation coefficient of 0.984 (10 to 100 mM), and UTE phase showed potential for even higher concentrations with a correlation coefficient of 0.992 (100 mM or above).
참고문헌 (11)
- Padhani AR, "Dynamic contrast-enhanced MRI studies in oncology with an emphasis on quantification, validation and human studies", Clin Radiol, 56, pp.607~620 (2001)
- Kuo PH, "Gadoliniumbased MR contrast agents and nephrogenic systemic fibrosis", Radiology, 242, pp.647~649 (2007)
- Kanda T, "Gadolinium-based contrast agent accumulates in the brain Even in subjects without severe renal dysfunction : evaluation of autopsy brain specimens with inductively coupled plasma mass spectroscopy", Radiology, 276, pp.228~232 (2015)
- Caravan P, "Strategies for increasing the sensitivity of gadolinium based MRI contrast agents", Chem Soc Rev, 35, pp.512~523 (2006)
- Trattnig S, "Threedimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) for in vivo evaluation of reparative cartilage after matrix-associated autologous chondrocyte transplantation at 3.0T: Preliminary results", J Magn Reson Imaging, 26, pp.974~982 (2007)
- Sasaki M, "Enhancement effects and relaxivities of gadolinium-DTPA at 1.5 versus 3Tesla: a phantom study", Magn Reson Med Sci, 4, pp.145~149 (2005)
- Robson MD, "Magnetic resonance : an introduction to ultrashort TE(UTE)imaging", J Comput Assist Tomogr, 27, pp.825~846 (2003)
- Hittmair K, "Method for the quantitative assessment of contrast agent uptake in dynamic contrast-enhanced MRI", Magn Reson Med, 31, pp.567~571 (1994)
- Li W, "Integrated Laplacianbased phase unwrapping and background phase removal for quantitative susceptibility mapping", NMR Biomed, 27, pp.219~227 (2014)
- Poselt E, "Relaxivity optimization of a PEGylated iron-oxide-based negative magnetic resonance contrast agent for T(2)-weighted spinecho imaging", ACS Nano, 6, pp.1619~1624 (2012)
- Sosnovik DE, "Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications", Basic Res Cardiol, 103, pp.122~130 (2008)