Diagnostic Significance of pH-Responsive Gd3+-Based T1 MR Contrast Agents
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We discuss recent advances in Gd-based T1-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as 3 mm3. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.
Abstract
We discuss recent advances in Gd-based T1-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as 3 mm3. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.
참고문헌 (37)
- Boron WF, "Medical physiology: a cellular and molecular approach", pp.2008, Saunders
- Lambers H, "Natural skin surface pH is on average below 5, which is beneficial for its resident flora", Int J Cosmet Sci, 28, pp.359~370 (2006)
- Han J, "Fluorescent indicators for intracellular pH", Chem Rev, 110, pp.2709~2728 (2010)
- Adrogué HJ, "Blackwell’s basics of medicine", pp.49~133 (1994), Blackwell Science
- Vander Heiden MG, "Understanding the Warburg effect: the metabolic requirements of cell proliferation", Science, 324, pp.1029~1033 (2009)
- Behne MJ, "Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function", J Invest Dermatol, 120, pp.998~1006 (2003)
- Ilic D, "Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+", H+exchanger 1 plasma membrane localization, 2007, pp.170, 2055~2067
- Okabe Y, "Tissue-specific signals control reversible program of localization and functional polarization of macrophages", Cell, 157, pp.832~844 (2014)
- Lee MH, "Mitochondria-immobilized pH-sensitive off-on fluorescent probe", J Am Chem Soc, 136, pp.14136~14142 (2014)
- Chen G, "Wide-acidity-range pH fluorescence probes for evaluation of acidification in mitochondria and digestive tract mucosa", Anal Chem, 89, pp.8509~8516 (2017)
- Podder A, "A two-photon fluorescent probe records the intracellular pH through 'OR' logic operation via internal calibration", Sensors and Actuators B:Chemical, 268, pp.195~204 (2018)
- Raghunand N, "Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy", Biochem Pharmacol, 57, pp.309~312 (1999)
- Mason RP, "Transmembrane pH gradients in vivo:measurements using fluorinated vitamin B6 derivatives", Curr Med Chem, 6, pp.481~499 (1999)
- Ojugo AS, "Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous (19)F and (31)P probes", NMR Biomed, 12, pp.495~504 (1999)
- van Sluis R, "In vivo imaging of extracellular pH using 1H MRSI", Magn Reson Med, 41, pp.743~750 (1999)
- Garcia-Martin ML, "Mapping extracellular pH in rat brain gliomas in vivo by 1H magnetic resonance spectroscopic imaging: comparison with maps of metabolites", Cancer Res, 61, pp.6524~6531 (2001)
- Vermathen P, "Administration and (1)H MRS detection of histidine in human brain:application to in vivo pH measurement", Magn Reson Med, 43, pp.665~675 (2000)
- Mori S, "Proton NMR spectroscopy of solvent-saturable resonances: a new approach to study pH effects in situ", Magn Reson Med, 40, pp.36~42 (1998)
- Ward KM, "Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST)", Magn Reson Med, 44, pp.799~802 (2000)
- Goldman MR, "Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging and paramagnetic ion contrast enhancement in excised canine hearts", Circulation, 66, pp.1012~1016 (1982)
- Caravan P, "Strategies for increasing the sensitivity of gadolinium based MRI contrast agents", Chem Soc Rev, 35, pp.512~523 (2006)
- Koenig SH, "A novel derivation of the Solomon-Bloembergen-Morgan equations: application to solvent relaxation by Mn2+-protein complexes", J Magn Reson, 31, pp.1~10 (1978)
- Westlund PO, "A generalized Solomon-Bloembergen-Morgan theory for arbitrary electron spin quantum number S - the dipole-dipole coupling between a nuclear spin I = 1", 2 and an electron spin system S = 5, Mol Phys, pp.1995, 85[DOI]
- Kowalewski J, "Nuclear spin relaxation in paramagnetic systems: electron spin relaxation effects under near-red field limit conditions and beyond", J Phys Chem A, 106, pp.7376~7382 (2002)
- Yin J, "MRI relaxivity enhancement of gadolinium oxide nanoshells with a controllable shell thickness", Phys Chem Chem Phys, 20, pp.10038~10047 (2018)
- Zech SG, "Protein binding to lanthanide(III) complexes can reduce the water exchange rate at the lanthanide", Inorg Chem, 46, pp.3576~3584 (2007)
- Werner EJ, "High-relaxivity MRI contrast agents: where coordination chemistry meets medical imaging", Angew Chem Int Ed Engl, 47, pp.8568~8580 (2008)
- Zhang S, "A novel pH-Sensitive MRI contrast agent", Angew Chem Int Ed Engl, 38, pp.3192~3194 (1999)
- Ali MM, "Synthesis and relaxometric studies of a dendrimer-based pH-responsive MRI contrast agent", Chemistry, 14, pp.7250~7258 (2008)
- Garcia-Martin ML, "High resolution pH(e) imaging of rat glioma using pH-dependent relaxivity", Magn Reson Med, 55, pp.309~315 (2006)
- Aime S, "A R2", R1 ratiometric procedure for a concentration-independent, pH-responsive, Gd(III)-based MRI agent, 2006, pp.128, 11326~11327
- Toth E, "Water-soluble gadofullerenes: toward high-relaxivity, pH-responsive MRI contrast agents", J Am Chem Soc, 127, pp.799~805 (2005)
- Bhuniya S, "Uridine-based paramagnetic supramolecular nanoaggregate with high relaxivity capable of detecting primitive liver tumor lesions", Biomaterials, 32, pp.6533~6540 (2011)
- Woods M, "Synthesis, relaxometric and photophysical properties of a new pH-responsive MRI contrast agent: the effect of other ligating groups on dissociation of a p-nitrophenolic pendant arm", J Am Chem Soc, 126, pp.9248~9256 (2004)
- Frullano L, "Bimodal MR-PET agent for quantitative pH imaging", Angew Chem Int Ed Engl, 49, pp.2382~2384 (2010)
- Moriggi L, "Serum albumin targeted, pH-dependent magnetic resonance relaxation agents", Chemistry, 18, pp.3675~3686 (2012)
- Kim KS, "A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle", Biomaterials, 35, pp.337~343 (2014)
