Quantitative Susceptibility Mapping of Oxygen Metabolism: A Feasibility Study Utilizing a Large-Scale Clinical Dataset
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Purpose: The aim of the present study was to investigate the potential utility of the magnetic susceptibility-based assessment of cerebral oxygen metabolism with a dataset from a memory clinic. Materials and Methods: We collected and processed three-dimensional gradient-recalled echo phase data of 290 participants. To analyze oxygen metabolism, quantitative susceptibility mapping was performed for two major veins (superior sagittal sinus and straight sinus), and the venous oxygen saturation was estimated. Results: The estimated venous oxygen saturations of the two major veins were positively correlated with the clinical and volumetric measurements. They did not differ with the clinical diagnosis or clinical dementia rating. The values of the superior sagittal sinus were associated with the presence of the apolipoprotein E type 4 allele, when considering age, sex, and their interactions. Conclusion: The results demonstrate that quantitative susceptibility mapping of clinically available three-dimensional susceptibility-weighted imaging sequences in a large-scale clinical dataset can estimate cerebral oxygen metabolism.
Abstract
Purpose: The aim of the present study was to investigate the potential utility of the magnetic susceptibility-based assessment of cerebral oxygen metabolism with a dataset from a memory clinic. Materials and Methods: We collected and processed three-dimensional gradient-recalled echo phase data of 290 participants. To analyze oxygen metabolism, quantitative susceptibility mapping was performed for two major veins (superior sagittal sinus and straight sinus), and the venous oxygen saturation was estimated. Results: The estimated venous oxygen saturations of the two major veins were positively correlated with the clinical and volumetric measurements. They did not differ with the clinical diagnosis or clinical dementia rating. The values of the superior sagittal sinus were associated with the presence of the apolipoprotein E type 4 allele, when considering age, sex, and their interactions. Conclusion: The results demonstrate that quantitative susceptibility mapping of clinically available three-dimensional susceptibility-weighted imaging sequences in a large-scale clinical dataset can estimate cerebral oxygen metabolism.
참고문헌 (16)
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