신경병증성 토끼모델에서 고전압맥동천류의 창상치유 효과

Abstract

The purpose of this study was to determine whether high voltage pulsed currentstimulation (HVPCS) would enhance wound healing in neuropathic rabbits. Ten rabbitswere assigned to either an experimental or a control group. The wounded part aroundthe peripheral neuropathy of the experimental rabbits was stimulated for two hourstwice a day for six days under the following conditions: pulse frequency 80 pps, pulseduration 100 μS ， and stimulation intensity 30-40 V. The results indicated that therewas no difference in the wound closure between the experimental and control groups. The two groups showed similar aspects in collagen and reticulum, which were observedby colored Masson’s trichome. While the rabbits in the control group had more or lessthick fibers, the rabbits in the experimental group had thin and branched-shape fibers. The rabbits in the experimental group showed both strong responses in the shaping ofelastic fibers and the increased aspects in fibroblast when compared with the controlgroup.