본문 바로가기
KERD
논문

The Regulation of Lipolysis in Adipose Tissue

이기춘|Xiang Li|Julie Serr
한국축산학회 (Korean Society of Animal Sciences and Technology)|2013.08|한국축산학회지 (Journal of Animal Science and Technology)|제55권 제4호|pp. 303-314

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

LipolysisMGLCGI-58HSLATGLG0S2
주제분류축산학

초록

Knowledge regarding lipid catabolism has been of great interest in the field of animal sciences. In the livestock industry, excess fat accretion in meat is costly to the producer and undesirable to the consumer. However, intramuscular fat(marbling) is desirable to enhance carcass and product quality. The manipulation of lipid content to meet the goals of animal production requires an understanding of the detailed mechanisms of lipid catabolism to help meticulously design nutritional, pharmacological, and physiological approaches to regulate fat accretion. The concept of a basic system of lipases and their co-regulators has been identified. The major lipases cleave triacylglycerol(TAG) stored in lipid droplets in a sequential manner. In adipose tissue, adipose triglyceride lipase(ATGL) performs the first and rate-limiting step of TAG breakdown through hydrolysis at the sn-1 position of TAG to release a non-esterified fatty acid(NEFA) and diacylglycerol(DAG). Subsequently, cleavage of DAG occurs via the rate-limiting enzyme hormone-sensitive lipase(HSL) for DAG catabolism, which is followed by monoglyceride lipase (MGL) for monoacylglycerol(MAG) hydrolysis. Recent identification of the co-activator(Comparative Gene Identification-58) and inhibitor [G(0)/G(1) Switch Gene 2] of ATGL have helped elucidate this important initial step of TAG breakdown, while also generating more questions. Additionally, the roles of these lipolysis-related enzymes in muscle, liver and skin tissue have also been found to be of great importance for the investigation of systemic lipolytic regulation.

Abstract

Knowledge regarding lipid catabolism has been of great interest in the field of animal sciences. In the livestock industry, excess fat accretion in meat is costly to the producer and undesirable to the consumer. However, intramuscular fat(marbling) is desirable to enhance carcass and product quality. The manipulation of lipid content to meet the goals of animal production requires an understanding of the detailed mechanisms of lipid catabolism to help meticulously design nutritional, pharmacological, and physiological approaches to regulate fat accretion. The concept of a basic system of lipases and their co-regulators has been identified. The major lipases cleave triacylglycerol(TAG) stored in lipid droplets in a sequential manner. In adipose tissue, adipose triglyceride lipase(ATGL) performs the first and rate-limiting step of TAG breakdown through hydrolysis at the sn-1 position of TAG to release a non-esterified fatty acid(NEFA) and diacylglycerol(DAG). Subsequently, cleavage of DAG occurs via the rate-limiting enzyme hormone-sensitive lipase(HSL) for DAG catabolism, which is followed by monoglyceride lipase (MGL) for monoacylglycerol(MAG) hydrolysis. Recent identification of the co-activator(Comparative Gene Identification-58) and inhibitor [G(0)/G(1) Switch Gene 2] of ATGL have helped elucidate this important initial step of TAG breakdown, while also generating more questions. Additionally, the roles of these lipolysis-related enzymes in muscle, liver and skin tissue have also been found to be of great importance for the investigation of systemic lipolytic regulation.

참고문헌 (89)

  1. Ailhaud, G., "Development of white adipose tissue. Handbook of Obesity, Etiology and Pathophysiology", pp.48~ (2004), Marcel Dekker
  2. Bernlohr, D. A., "Adipose tissue and lipid metabolism, In Biochemistry of Lipids, Lipoproteins and Membrances", pp.263~289 (2002), Elsevier
  3. Bertrand, T., "Structural basis for human monoglyceride lipase inhibition", J. Mol. Biol, 396, pp.663~673 (2010)
  4. Borgström, B, "Pancreatic juice co-lipase: physiological importance", Biochim. Biophys. Acta, 20, pp.509~513 (1971)
  5. Chakrabarti, P., "Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage", Diabetes, 59, pp.775~781 (2010)
  6. Chanarin, I., "Neutral-lipid storage disease: a new disorder of lipid metabolism", Br. Med. J, 1, pp.553~555 (1975)
  7. Cinti, S., "The role of brown adipose tissue in human obesity", Nutr. Metab. Cardiovasc. Dis, 16, pp.569~574 (2006)
  8. Cornaciu, I., "The minimal domain of adipose triglyceride lipase(ATGL)ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively", PLoS One, 6, pp.26349~ (2011)
  9. Coppack, S. W., "In vivo regulation of lipolysis in humans", J. Lipid Res, 35, pp.177~193 (1994)
  10. DeFronzo, R. A., "Pathogenesis of type 2 diabetes mellitus", Med. Clin. North Am, 88, pp.787~835 (2004)
  11. Deiuliis, J. A., "The metabolic and molecular regulation of adipose triglyceride lipase", 박사, pp.2007
  12. Deiuliis, J. A., "Developmental, hormonal, and nutritional regulation of porcine adipose triglyceride lipase(ATGL)", Lipids, 43, pp.215~225 (2008)
  13. Eastmond, P. J., "Sugar-dependent1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds", Plant Cell, 18, pp.665675~ (2006)
  14. Enerbäck, S., "Human brown adipose tissue", Cell Metab, 11, pp.248~252 (2010)
  15. Festuccia, W. T., "PPARgamma agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control", Diabetologia, 49, pp.2427~2436 (2006)
  16. Fischer, J., "Neutral lipid storage diseases and ATGL(adipose triglyceride lipase) and CGI-58", ABHD5(alpha-beta hydrolase domain-containing 5) deficiency: myopathy, ichthyosis, but not obesity, 2007, pp.23, 575~578
  17. Fortin, A., "The eating quality of Canadian pork and its relationship with intramuscular fat", Meat Sci, 69, pp.297~305 (2005)
  18. Gardan, D., "Lipid metabolism and secretory function of porcine intramuscular adipocytes compared with subcutaneous and perirenal adipocytes", Am. J. Physiol. Endocrinol. Metab, 291, pp.372~380 (2006)
  19. Ghosh, A. K., "CGI-58, the causative gene for Chanarin-Dorfman syndrome, mediates acylation of lysophos- phatidic acid", J. Biol.Chem, 283, pp.24525~24533 (2008)
  20. Giordano, A., "Adipose organ nerves revealed by immunohistochemistry", Methods Mol. Biol, 456, pp.83~95 (2008)
  21. Gjerlaug-Enger, E., "Genetic parameters of meat quality traits in two pig breeds measured by rapid methods", Animal, 4, pp.1832~1843 (2010)
  22. Granneman, J. G., "Analysis of lipolytic protein trafficking and interactions in adipocytes", J. Biol. Chem, 282, pp.5726~5735 (2007)
  23. Gruber, A., "The N-terminal region of comparative gene identification-58 (CGI-58) is important for lipid droplet binding and activation of adipose triglyceride lipase", J. Biol. Chem, 285, pp.12289~12298 (2010)
  24. Hamill, R. M., "Functional analysis of muscle gene expression profiles associated with tenderness and intramuscular fat content in pork", Meat Sci, 92, pp.440~450 (2012)
  25. Hausman, G. J., "Board-invited review: the biology and regulation of preadipocytes and adipocytes in meat animals", J. Anim. Sci, 87, pp.1218~1246 (2009)
  26. Holm, C., "Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue", Biochem. Biophys. Res. Commun, 148, pp.99~105 (1987)
  27. Holm, C., "Hormone-sensitive lipase: structure, function, evolution and overproduction in insect cells using the baculovirus expression system", Protein Eng, 7, pp.537~541 (1994)
  28. Hovenier, R., "Repeatability of taste panel tenderness scores and their relationships to objective pig meat quality traits", J. Anim. Sci, 71, pp.2018~2025 (1993)
  29. Jenkins, C. M., "Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities", J. Biol. Chem, 279, pp.48968~48975 (2004)
  30. Jeong, J., "Expression of fat deposition and fat removal genes is associated with intramuscular fat content in longissimus dorsi muscle of Korean cattle steers.", J. Anim. Sci, 90, pp.2044~20453 (2012)
  31. Jocken, J. W., "Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state", J. Clin. Endocrinol. Metab, 92, pp.2292~2299 (2007)
  32. Karlsson, M., "cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases", J. Biol. Chem, 272, pp.27218~27223 (1997)
  33. Kershaw, E. E., "Adipose triglyceride lipase : function, regulation by insulin, and comparison with adiponutrin", Diabetes, 55, pp.148~157 (2006)
  34. Kim, J. Y., "The adipose tissue triglyceride lipase ATGL", PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPARgamma, 2006, pp.291, E115~E127
  35. Kinnunen, P. K., "Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II", Proc. Natl. Acad. Sci. USA, 74, pp.4848~4851 (1977)
  36. Kraemer, F. B., "Detection of hormone-sensitive lipase in various tissues. I. Expression of an HSL", bacterial fusion protein and generation of anti-HSL antibodies, 1993, pp.34, 663~671
  37. Kralisch, S., "Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes", Mol. Cell. Endocrinol, 240, pp.43~49 (2005)
  38. Labar, G. C., "Crystal structure of the human mono- acylglycerol lipase, a key actor in endocannabinoid signaling", Chembiochem, 11, pp.218~227 (2010)
  39. Lake, A. C., "Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members", J. Lipid Res, 46, pp.2477~2487 (2005)
  40. Langin, D., "Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antartic bacterium", Proc. Natl. Acad. Sci, 90, pp.4897~4901 (1993)
  41. Lass, A., "Lipolysis- a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores", Prog. Lipid Res, 50, pp.14~27 (2011)
  42. Lass, A., "Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome", Cell Metab, 3, pp.309~319 (2006)
  43. Lau, D. C., "Adipokines: molecular links between obesity and atherosclerosis", Am. J. Physiol. Heart Circ. Physiol, 288(5), pp.H2031~H2041 (2005)
  44. Lee, S. H., "Identification of differentially expressed genes related to intramuscular fat development in the early and late fattening stages of hanwoo steers", J. Biochem. Mol. Biol, 40, pp.757~764 (2007)
  45. Lee, K., "Cloning of adipose triglyceride lipase in poultry and expression of adipose triglyceride lipase during development of adipose in chickens", Poult. Sci, 88, pp.620~630 (2009)
  46. Lefèvre, C., "Mutations in CGI-58, the gene encoding a new protein of the esterase", lipase, Am. J. Hum. Genet, pp.2001, 69[DOI]
  47. Lefèvre, C., "Mutations in CGI-58, the gene encoding a new protein of the esterase", lipase, Am. J. Hum. Genet, pp.2001, 69[DOI]
  48. Li, X., "Alternative splicing and developmental and hormonal regulation of porcine comparative gene identification-58 (CGI-58) mRNA", J. Anim. Sci, 90, pp.4346~4354 (2012)
  49. Li, Y., "Effects of leptin on porcine primary adipocytes lipolysis and mRNA expression of key lipolytic enzymes", Sheng Wu Gong Cheng Xue Bao, 24, pp.1612~1619 (2008)
  50. Li, Y. C., "Regulation of ATGL expression mediated by leptin in vitro in porcine adipocyte lipolysis", Mol. Cell Biochem, 333(1-2), pp.121~128 (2010)
  51. Liu, L. F., "Regulation of adipose triglyceride lipase by rosiglitazone", Diabetes Obes. Metab, 11, pp.131~142 (2009)
  52. Lu, X., "Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2", Cell Cycle, 9, pp.2719~2725 (2010)
  53. McGarry, J. D, "Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes", Diabetes, 51, pp.7~18 (2002)
  54. Miyoshi, H., "Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes", J. Cell Biochem, 105, pp.1430~1436 (2008)
  55. Miyoshi, H., "Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and -independent mecha- nisms", J. Biol. Chem, 281, pp.15837~15844 (2006)
  56. Montero-Moran, G., "CGI-58", ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase, 2010, pp.51, 709~719
  57. Mourot, J., "Lipogenic enzyme activities in muscles of growing Large White and Meishan Pigs", Livest. Prod. Sci, 55, pp.127~133 (1998)
  58. Notari, L, Baladron, V., "Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor", J. Biol. Chem, 281, pp.38022~38037 (2006)
  59. Oh, S. A., "Cloning of avian G(0)", G(1) switch gene 2 genes and developmental and nutritional regulation of G(0), J. Anim. Sci, pp.2010, 89[DOI]
  60. Ollis, D. L., "The alpha", beta hydrolase fold, 1992, pp.5, 197~211
  61. Osterlund, T., "Domain-structure analysis of recombinant rat hormone-sensitive lipase", Biochem. J, 319, pp.411~420 (1996)
  62. Pagnon, J., "Identification and Functional Characterization of Protein Kinase A Phosphorylation Sites in the Major Lipolytic Protein, Adipose Triglyceride Lipase", Endocrinology, 153, pp.4278~4289 (2012)
  63. Pethick, D. W., "Growth, development and nutritional manipulation of marbling in cattle: a review", Aust. J. Exp.Agric, 44, pp.705~715 (2004)
  64. Peyot, M. L., "Adipose triglyceride lipase is implicated in fuel- and non-fuel- stimulated insulin secretion", J. Biol. Chem, 284, pp.16848~16859 (2009)
  65. Radner, F. P., "Fat in the skin: Triacylglycerol metabolism in keratinocytes and its role in the development of neutral lipid storage disease", Dermatoendocrinol, 3, pp.77~83 (2011)
  66. Russell, L, "A human putative lymphocyte G0", G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated, 1991, pp.10, 581~591
  67. Schlosburg, J. E., "Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system", Nat. Neurosci, 13, pp.1113~1119 (2010)
  68. Schweiger, M., "Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase", PNPLA2 or CGI-58, Am. J. Physiol. Endocrinol. Metab, pp.2009, 297[DOI]
  69. Schweiger, M., "The C-terminal region of human adipose triglyceride lipase affects enzyme activity and lipid droplet binding", J. Biol. Chem, 283, pp.17211~17220 (2008)
  70. Serr, J., "Regulation of adipose triglyceride lipase by fasting and refeeding in avian species", Poult. Sci, 88, pp.2585~2591 (2009)
  71. Serr, J, "Cloning of comparative gene identification-58 gene in avian species and investigation of its developmental and nutritional regulation in chicken adipose tissue", J. Anim. Sci, 89, pp.3490~3500 (2011)
  72. Shan, T., "Breed difference and regulation of the porcine adipose triglyceride lipase and hormone sensitive lipase by TNFalpha", Anim. Genet, 40, pp.863~870 (2009)
  73. Shen, W. J., "Characterization of the functional interaction of adipocyte lipid- binding protein with hormone-sensitive lipase", J. Biol. Chem, 376, pp.49443~49448 (2001)
  74. Smekal, G., "Effect of endurance training on muscle fat metabolism during prolonged exercise : agreements and disagreements", Nutrition, 19, pp.891~900 (2003)
  75. Subramanian, V., "Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes", J. Biol. Chem, 279, pp.42062~42071 (2004)
  76. Tornqvist, H., "Determination of protein in adipose tissue extracts", FEBS Lett, 75, pp.259~264 (1976)
  77. Vaughan, M., "Hormone- sensitive lipase and monoglyceride lipase activities in adipose tissue", J. Biol. Chem, 239, pp.401409~ (1964)
  78. Villena, J. A., "Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis", J. Biol. Chem, 279, pp.47066~47075 (2004)
  79. Waki, H., "Endocrine functions of adipose tissue", Annu. Rev. Pathol, 2, pp.31~56 (2007)
  80. Watt, M. J., "Regulation and function of triacylglycerol lipases in cellular metabolism", Biochem. J, 414, pp.313~325 (2008)
  81. Xu, C., "Direct effect of glucocorticoids on lipolysis in adipocytes", Mol. Endocrinol, 23, pp.1161~1170 (2009)
  82. Yamaguchi, T., "CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome", J. Biol. Chem, 279, pp.30490~30497 (2004)
  83. Yang, X, "Identification of a novel splicing isoform of murine CGI-58", FEBS Lett, 584, pp.903~910 (2010)
  84. Yang, X, "The G(0)", G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase, 2010, pp.11, 194~205
  85. Zandenbergen, F., "The G0", G1 switch gene 2 is a novel PPAR target gene, 2005, pp.392, 313~324
  86. Zechner, R., "Lipolysis: pathway under construction", Curr. Opin. Lipidol, 16, pp.333~340 (2005)
  87. Zhang, Y., "Positional cloning of the mouse obese gene and its human homologue", Nature, 372, pp.425~432 (1994)
  88. Zhao, S. M., "Differential expression of lipid metabolism related genes in porcine muscle tissue leading to different intramuscular fat deposition", Lipids, 44, pp.1029~1037 (2009)
  89. Zimmermann, R., "Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase", Science, 306, pp.1383~1386 (2004)

관련 논문AI추천

Lipid remodeling of adipose tissue in metabolic health and disease박주홍, 이재원, 정영석, Cho Yoon Keun, Doh Junsang, Lee Sumin, Lee Yun-Hee생화학분자생물학회 · Experimental and Molecular Medicine2023 · 제55권 Role of Dgat2 in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes부소영한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2023 · 제33권 제12호Medicarpin induces lipolysis via activation of Protein Kinase A in brown adipocytes김용식, 윤다현, 이태진, Khan Mohammad Imran생화학분자생물학회 · BMB Reports2018 · 제51권 제5호mRNA Expression of Ovine Angiopoietin-like Protein 4 Gene in Adipose TissuesChen Liang, Jian-Hua Liu, Jing Zhang, Jiong-Jie Jing, Li-Ying Qiao, Wen-Zhong Liu, Xia-Li Jia아세아·태평양축산학회 · Animal Bioscience2016 · 제29권 제5호Channel Function of TRPML1 Prompts Lipolysis in Mature Adipocytes김미성, 김민석대한구강생물학회 · International Journal of Oral Biology2018 · 제43권 제1호Effects of Starvation on Lipid Metabolism and Gluconeogenesis in YakJiuqiang Guan, Quanhui Peng, Tianwu An, Xiaolin Luo, Xiaoqiang Yu, Zhisheng Wang아세아·태평양축산학회 · Animal Bioscience2016 · 제29권 제11호

이 간행물의 다른 논문 (11건)

Identification of SNPs Affecting Porcine Carcass Weight with the 60K SNP Chip이준헌, 서동원, 임현태, 강권, 박희복, 정은지, 이재봉, 조인철pp. 231-235Effects of Endocrine Disruptors(NP, DBP and BPA) on Sperm Characteristics and Development of IVF Embryos in Pig정희태, 양부근, 여인서, 박인철, 박춘근, 김종택pp. 237-247The Expression Patterns of Connexin Isoforms in the Rat Caput Epididymis During Postnatal Development한수영, 이기호pp. 249-255Effects of Fruit By-product Extracts Supplementation on Growth Performance and Nutrient Digestibility in Growing PigsZheng Fan Zhang, 김인호, 조진호, 이세훈, 홍준기, 박성권, 박준철pp. 257-261Effects of Origins of Soybean Meal on Growth Performance, Nutrient Digestibility and Fecal Microflora of Growing Pigs김진수, 김영화, 이수협, 채병조, Santosh Laxman Ingale, Yun Kupp. 263-272
원문 보기