三一腎氣丸이 methotrexate로 誘發된 흰쥐의 免疫機能低下에 미치는 影響
The Effect of Samilshinkihwan on Immunosuppression Induced in Rats by Methotrexate
1
조회
0
다운로드
1
인용
0
참고문헌
초록
Abstract
Objective : To investigate the effect of Samilshinkihwan(SISKW) on white rats with deteriorated immunity caused by methotrexate.Methods : The test articles were dosed once a day for 14 days by gastric gavage at a dosage 1000, 500 and 250㎎/㎏/10㎖ of SISKW from 2 days after last MTX-dosing, and changes in body weight, spleen weight, total blood leukocyte numbers, total lymphocyte numbers, B and T lymphocyte ratio, CD3+CD4+, CD3+/CD8+ and CD4+/CD8+ T lymphocyte ratio in the blood and spleen were measured. In addition, the serum interleukin (IL)-2 levels and the productivity of IL-2 of splenic cells were also demonstrated in this study.Results : The changes on body weight increased significantly in the 1000㎎/㎏of SISKW group. The changes on the spleen weight, the total blood leukocytenumbers, the total lymphocyte numbers in the blood and spleen, the ratio of T-cell in the blood and spleen and the ratio of CD3+CD4+ T-cell in spleen increased significantly in all SISKW groups as compared with the control group. The ratio of CD4+/CD8+ T-cells in blood increased significantly. The serum IL-2 levels and productivity of IL-2 of splenic cells increased significantly in 1000 and 500㎎/㎏ SISKW groups as compared with the control group.Conclusions : Samilshinkihwanhas an effect of increasing immune responses, especially on cellular immune responses, in white rats with deteriorated immunity caused by methotrexate.
참고문헌 (25)
- "세포분자면역학", pp.3~38 (2002), 범문사
- "黃帝內經讀解", pp.12~ (2000), 成輔社
- "今釋黃帝內經靈樞", pp.277~ (1995), 成輔社
- "면역과 한방", pp.19~ (1998), 열린책들
- "實驗硏究 虛證和實證病因的免疫狀態", 6, pp.44~6 (1984)
- "加味補兒湯의 免疫調節作用에 對한 實驗的 硏究", 14(2), pp.61~84 (2000)
- "Taurine protects against methotrexate- induced toxicity and inhibits leukocyte death", 209(1), pp.39~50 (2005)
- "黃水鍼이 methotrexate를 투여한 생쥐의 免疫機能低下에 미치는 영향", pp.49~66 (1994)
- "濃度差에 따른 黃藥鍼이 methotrexate를 투여한 생쥐의 면역기능저하에 미치는 영향", pp.67~81 (1994)
- "何首烏가 methotrexate로 유도된 흰쥐의 免疫機能低下에 미치는 影響", 4(2), pp.152~169 (2000)
- "固眞飮子가 methotrexate로 유발된 흰쥐의 免疫機能低下에 미치는 影響", 25(4), pp.117~128 (2004)
- "黃建中湯이 methotrexate로 유도된 흰쥐의 免疫機能低下에 미치는 影響", 18(1), pp.27~48 (2004)
- "對譯東醫寶鑑", pp.1183~1184 (1999), 法人文化社
- "免疫에 관한 東洋醫學的 考察" (1986)
- "면역과 알레르기", pp.9~10 (1990)
- "면역 및 알레르기학", pp.1~12 (1999), 전남대학교 출판부
- "면역학 길라잡이", pp.37~ (2000), 고려의학
- "細胞分子免疫學", pp.30~ (1998), 正門閣
- "免疫의 意味論", pp.117~121 (1998), 한울
- "Hormones and immune responsiveness in chronic lymphocytic leukemia", pp.483~9 (1992)
- "Spectrum of expression of intestinal cellular immunity proposal for a charge in dignostic criteria of celiac disease", pp.29~32 (1993)
- "Prognostic Value of Hiv-1 Syncytium-inducing Phenotype for Rate of CD4+ T-cell Depletion and Progression to AIDS", 118, pp.681~8 (1993)
- "이우주의 약리학강의", pp.622~ (1993), 의학문화사
- "임상약리학총서 Ⅰ 임상약학개론", pp.180~ (1991), 희성출판사
- "Effect of lactoferrin on the methotrexate-induced suppression of the cellular and humoral immune response in mice", 24(6), pp.3831~3836 (2004)