固眞飮子가 methotrexate로 유발된 흰쥐의 免役機能低下에 미치는 影響(영향)
Effects of Gojineumja on Immunosuppression Induced by Methotrexate in Rat
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Abstract
Objectives : To examine the effects of Gojineumja on white rats which deteriorated immunity caused by Methotrexate(MTX), first of all, MTX was fed to the rats once a day for 4 day. Methods : After the immune response of the rats are deteriorated, dried extracts of Gojineumja(GJE) mixed in water was fed to the white rats once a day for 14days. The next conclusion was made by examining the rates of B-cells and T-cells of the peripheral blood and the changes in rates of CD4+ T-cells and CD8+ T-cells of the blood sampled from the spleen and peripheral region. Especially the count of CD3+ CD4+ T-cells of the peripheral blood and the count of CD3+ CD4+ T-cells of the spleen the count of CD4+/ CD8+ T-cell of the peripheral blood and the spleen proved the significant effect of increasing immune responses statistically. Results : ① The following are the summary of the results. ② The percentage of B lymphocyte of peripheral blood was increased significantly in GJE group as compared with control group. ③ The percentage of CD3+ CD4+ T-cell of peripheral blood was increased significantly in GJE group as compared with control group. ④ The percentage of CD3+ CD8+ T-cell of peripheral blood was not different statistically. ⑤ The percentage of CD4+/ CD8+ T-cell of peripheral blood was increased significantly in GJE group as compared with control group. ⑥ The percentage of CD3+ CD4+ T-cell of spleen was increased significantly in GJE group as compared with control group. ⑦ The percentage of CD3+ CD8+ T-cell was not different statistically. ⑧ The percentage of CD4+ /CD8+ T-cell was not different statistically. Conclusions : Gojineumja has an effect of increasing immune responses on white rats with deteriorated immunity caused by MTX.
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