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뇌경색 입원환자대상으로 한약과 Warfarin의 복합 투여시 미치는 Prothrombin Time(INR)의 변화에 대한 후향적 단면연구

A Retrospective Sectional Study about the Effect of the Interaction of Herbal Medicines and Warfarin on Prothrombin Time(INR) in Stroke Patients

안세영|김영석|안영민|이병철|강철호|송문구|두호경|이상헌
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2007.09|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제28권 제3호|pp. 464-472

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참고문헌

주제분류한의학

초록

Abstract

Objectives : Nowadays the combined use of oriental herbal medicines and western biomedical medicines has been prevalent but controversial. Warfarin has been much reported to interact with some herbal medicines so that it influences prothrombin time(PT) & international normalized ratio(INR). This study was aimed to examine how much warfarin interacts with herbal medicines during treatment of stroke patients.Methods : This was a retrospective case control study of 53 patients whowere treated with concomitant treatment of herbal medicines & warfarin. They were within normal limit in liver function, renal function, hematocrit, hemoglobin, and platelet count at first admission lab. We classified them into 2 classes: study group (taking herbal medicines including Panax ginseng, Angelica sinensis, Zingiber officinale, Salvia miltiorrhiza that were reported to interact with warfarin to impact PT (INR)) and control group (taking other herbal medicines). We followed up PT (INR) at 5-10 days interval with AST, ALT, BUN, creatinine, hematocrit, hemoglobin, and platelet count.Results : AST, BUN, creatinine, hemoglobin, hematocrit, and platelet count were not changed significantly between first and final tests during the admission period. Only ALT decreased significantly in the control group. Neither baseline nor peak PT (INR) was significantly different between the groups. However, only warfarin dose was significantly correlated with PT and INR (r=0.810, r=0.798, p<0.01).Conclusions : It was concluded that PT(INR) was not influenced with herbal medicines and warfarin but by far dependent on warfarin dose in stroke patients restricted with normal liver function, renal function, and hematocrit, hemoglobin, and platelet count. Further prospective study is needed on larger samples to conclude that the combined therapy of herbal medicines and warfarin is safe.

참고문헌 (26)

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뇌졸중환자에서 한약과 양약의 병용투여가 간장 및 신장에 미치는 영향고창남, 박성욱, 윤성우, 이상욱, 이형철, 한지영대한한방내과학회 · 대한한방내과학회지2003 · 제24권 제1호경구용 항응고제를 복용하는 뇌경색 환자에서 프로스롬빈 타임에 영향을 주는 요인조광덕대한뇌졸중학회 · 대한뇌졸중영문학회지2003 · 제5권 제2호Warfarin 복용시 人蔘이 포함된 한약처방이 PT INR에 미치는 영향 - 10 증례보고 -권승원, 김영석, 문상관, 박주영, 변형식, 서유리, 윤승규, 정우상, 조기호대한한방내과학회 · 대한한방내과학회지2010 · 제31권 제3호뇌혈관질환에 대한 다빈도 처방 한약의 임상적 유효성 : 후향적 연구이인, 권정남, 서희정, 심소현, 홍진우대한한방내과학회 · 대한한방내과학회지2019 · 제40권 제6호편마비를 주소증으로 입원한 뇌경색 환자의 한방 치료 시기에 따른 치료 효과 분석 : 후향적 의무기록 분석고흥, 김기태, 신선미, 최유진대한한방내과학회 · 대한한방내과학회지2019 · 제40권 제4호한약 투여가 허혈성 질환 환자의 혈액 응고계에 미치는 영향유현희, 이성근한의병리학회 · 동의생리병리학회지2004 · 제18권 제4호

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