生地黃이 신절제술로 유도된 만성신부전 Rat에 미치는 影響
The Effects of Rehmannia on Nephrectomy-induced Chronic Renal Failure Rats
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The aim of the study was to investigate recovery effects of Rehmannia, which has been used clinically for chronic renal failure therapy. Mice had 5/6 nephrectomy to induce chronic renal failure. The results were as follows: 1. The protein amount in urine per 24hrs of the Rehmannia-treated group was significantly reduced compared to the control. 2. The albumin amount in the blood of the Rehmannia-treated group significantly increased compared to the control. The creatinine, total-cholesterol, LDL-cholesterol and triglyceride levels in serum of the Rehmannia-treated group as compared to the control were significantly inhibited. 3. The structural change in kidney of the Rehmannia-treated group was significantly inhibited compared to the control. 4. The factor (macrophage/monocyte antigen (ED-1), type IV collagen and angiotensin II type 1 (AT1) receptor) of the Rehmannia-treated group was significantly inhibited compared to the control, which induced the structural change in kidneys. The above results suggest that Rehmannia partially improved kidney function.
Abstract
The aim of the study was to investigate recovery effects of Rehmannia, which has been used clinically for chronic renal failure therapy. Mice had 5/6 nephrectomy to induce chronic renal failure. The results were as follows: 1. The protein amount in urine per 24hrs of the Rehmannia-treated group was significantly reduced compared to the control. 2. The albumin amount in the blood of the Rehmannia-treated group significantly increased compared to the control. The creatinine, total-cholesterol, LDL-cholesterol and triglyceride levels in serum of the Rehmannia-treated group as compared to the control were significantly inhibited. 3. The structural change in kidney of the Rehmannia-treated group was significantly inhibited compared to the control. 4. The factor (macrophage/monocyte antigen (ED-1), type IV collagen and angiotensin II type 1 (AT1) receptor) of the Rehmannia-treated group was significantly inhibited compared to the control, which induced the structural change in kidneys. The above results suggest that Rehmannia partially improved kidney function.
참고문헌 (35)
- 대한신장학회, "임상신장학", pp.593~725 (2001), 광문출판사
- 유경환, "만성신부전 환자에게 한약투여 후 사구체여과율 및 빈혈 호전 1례", 대한한방내과학회지, 26(2), pp.498~505 (2005), 대한한방내과학회
- Brenner BM, "Dietary Protein Intake and the Progressive Nature of Kidney Disease :Ｔhe Role of Hemodynamically Mediated Glomerular Injury in the Pathogenesis of Progressive Glomerular Sclerosis in Aging, Renal Ablation, and Intrinsic Renal Disease", N Engl J Med, 307, pp.652~659 (1982)
- Peterson, J C, "Blood pressure control, proteinuria and the progression of renal disease : The Modification of Diet in Renal Disease Study", Ann Intern Med, 123, pp.754~ (1995)
- Reric-Golia L, "peric-Golia M. Aortic and renal lesions in hypercholesterolemic adult male virgin Sprague-Dawley rats", Atherosclerosis, 46, pp.57~65 (1983)
- Border WA, "TGF-β in kidney fibrosis. A target for gene therapy", Kidney Int, 51, pp.1388~ (1997)
- 김용수, "우리나라 투석요법의 현황", 대한신장학회지, 11(3) (1992)
- 두호경, "신계내과학", pp.347~552 (1993), 동양의학연구원
- 황원덕, "慢性腎不全에 대한 沈香의 臨床適用報告", 대한한방내과학회지, 25(2), pp.368~378 (2004), 대한한방내과학회
- 신민교, "원색 임상본초학", pp.297~298 (1986), 남산당
- 신길구, "신씨본초학 <각론>", pp.88~89 (1973), 수문사
- 안상원, "熟地黃과 六味地黃湯이 노화과정 흰쥐에서의 항산화 기전에 미치는 영향", 대전대학교 한의학연구소 한의학논문집, 8(1), pp.593~623 (1999)
- 이경환, 김용성, 조수인, 최종배, "生地黃과 熟知黃의 흰쥐 신장에서의 항산화 효과", 대한한방내과학회지, 24(3), pp.522~530 (2003), 대한한방내과학회
- 이경환, "만성신부전으로 의심되는 환자에서 주증에 따른 한의학적 변증치료의 예", 대한한방내과학회지, 24(4), pp.1046~1054 (2003)
- 김경식, "地黃 수침이 실험적 신성고혈압 白鼠의 신장 기능에 미치는 영향", 대한침구학회지, 11(1), pp.225~239 (1994)
- Wong NL, "Effect of sodium on atrial natriuretic factor released in rats with chronic renal failure", Nephron, 61(4), pp.464~469 (1992)
- Shi S-R, "Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections", J. Histochem Cytochem, pp.742~748 (1991)
- Hsu, S M, "The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. A comparison between ABC and unlabeled antibody PAP procedures", J Histochem Cytochem, pp.577~580 (1981)
- 이종호, "만성신부전의 투석 전 치료", 대한내과학회지, 57(4), pp.783~789 (1999)
- 6 신절제 백서에서 enalapril과 lovastatin의 지연 투여가 사구체경화의 진행에 미치는 영향, "5", pp.1992, 이상구
- El Nahas AM, "Glomerulosclerosis : Insights into pathogenesis and treatment", Nephrol Dial Transplant, 4, pp.843~853 (1989)
- Remuzzi G, "Is glomerulosclerosis a consequence of altered glomerular permeability to macromolecules?", Kidney Int, 28, pp.384~394 (1990)
- Klahr S, "The influence of anticoagulation on the progression of experimental renal disease, in The Progressive Nature of Renal Disease", pp.45~ (1986), Churchill Livingstone
- Reric-Golia L, "Aortic and renal lesions in hypercholesterolemic adult male virgin Sprague-Dawley rats", Atherosclerosis, 46, pp.57~65 (1983)
- Border WA, "TGF-β in kidney fibrosis. A target for gene therapy", Kidney Int, 51, pp.1388~ (1997)
- Gretz N, "The remnant kidney model in: ;Experimental and Genetic Rat Models of Chronic Renal Failure", pp.1~28 (1993), Karger
- 양 위, "681례의 만성신부전 환자에 대한 각 단계에서의 사실겸증의 특점 분석", 동서의학, 32(2), pp.28~38 (2007)
- Waldherr R, "Natural course of the development of histologic lesions after 5", 6 nephrectomy, 1988, pp.60, 64~72
- 전상현, "흰쥐에서 부분적 신절제로 유발된 단백뇨와 진행성 신병변에 대한 Thromboxane A2-수용체 길항제 KT2-962의 효과" (1991), 한양대학교 대학원
- 김진규, "만성신부전의 임상병리 검사", 진단과 치료, 9(10), pp.1221~1224 (1989)
- 김상호, "일반병리학", pp.264~ (1997), 고문사
- Grond J, "Glomerular sclerotic lesions in the rat", Virchows Arch(B), 51, pp.521~524 (1980)
- 이소영, "배양된 메산지움 세포에서 고농도 포도당, 안지오텐신 II 및 안지오텐신 전환효소 억제제가 TGF-β 유전자 발현에 미치는 효과", 대한신장학회지, 18(4), pp.513~522 (1999)
- Raij L, "Glomerular mesangium : its function and relationship to angiotensin II", Am J Med, 79, pp.S24~ (1985)
- Norman J, "ECF induced mitogenesis in proximal tubular cells potentiation by angiotensin II", Am J Physiol, 253, pp.F299~ (1987)