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결명자 및 생리활성 성분의 약리학적 효과에 대한 실험연구 고찰

Comprehensive Review of Experimental Studies on Pharmacological Activities of Cassiae Semen and Bioactive Components

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초록

Objective : Cassiae semen has been used for a long time as a traditional medicinal herb in Eastern Asia. Despite the recent surge in experimental research of Cassiae semen, there is an increasing need for medical reinterpretation of its individual pharmacological effects. The purpose of this study is to investigate the pharmacological effects of Cassiae semen and its constituents. Methods : We included experimental studies related to the Cassiae Semen and bioactive components from 2013 to 2023 using NCBI PubMed, Research Information Service System (RISS), Korean studies Information Service System (KISS), and Korean medicine databases (Oriental Medicine Advanced Searching Integrated System [OASIS]). For 33 animal studies among experimental studies, SYRCLE's Risk of Bias Tool was used to assess the methodological quality. Data extraction included author, year, study design, and main efficacy results. The pharmacological actions of Cassia tora and active components were extracted according to disease group. Results and Conclusion : Based on the inclusion criteria, we selected 51 articles. The risk of bias assessment revealed that in animal studies, baseline characteristics, random housing, incomplete outcome data, and selective reporting were rated as low risk in most studies, while allocation concealment, blinding, and random outcome assessment were not reported in many studies. Cassiae semen and its components showed therapeutic effects including neuroprotection, anti-cancer, anti-metabolic syndrome, anti-inflammation, anti-degenerative joint disease, and hepatoprotection. The bioactive compounds of Cassiae semen are mainly anthraquinone compounds. The present study provided preliminary information for further clinical research on Cassiae semen and its active compounds.

Abstract

Objective : Cassiae semen has been used for a long time as a traditional medicinal herb in Eastern Asia. Despite the recent surge in experimental research of Cassiae semen, there is an increasing need for medical reinterpretation of its individual pharmacological effects. The purpose of this study is to investigate the pharmacological effects of Cassiae semen and its constituents. Methods : We included experimental studies related to the Cassiae Semen and bioactive components from 2013 to 2023 using NCBI PubMed, Research Information Service System (RISS), Korean studies Information Service System (KISS), and Korean medicine databases (Oriental Medicine Advanced Searching Integrated System [OASIS]). For 33 animal studies among experimental studies, SYRCLE's Risk of Bias Tool was used to assess the methodological quality. Data extraction included author, year, study design, and main efficacy results. The pharmacological actions of Cassia tora and active components were extracted according to disease group. Results and Conclusion : Based on the inclusion criteria, we selected 51 articles. The risk of bias assessment revealed that in animal studies, baseline characteristics, random housing, incomplete outcome data, and selective reporting were rated as low risk in most studies, while allocation concealment, blinding, and random outcome assessment were not reported in many studies. Cassiae semen and its components showed therapeutic effects including neuroprotection, anti-cancer, anti-metabolic syndrome, anti-inflammation, anti-degenerative joint disease, and hepatoprotection. The bioactive compounds of Cassiae semen are mainly anthraquinone compounds. The present study provided preliminary information for further clinical research on Cassiae semen and its active compounds.

참고문헌 (63)

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