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감기 치료 빈용 처방 구성 약물의 효능 연구

Efficacy of 20 Select Herbs Against Common Cold

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Objectives: To investigate the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines to test their efficacy in common cold treatment. Methods: For all experiments, the herbal medicines were extracted with 80% ethanol and freeze-dried. To determine the anti-oxidative properties, we tested DPPH-free radical-scavenging activity and xanthine oxidase inhibitory activity. To determine anti-inflammatory and analgesic potential, we investigated acetic acid-induced vascular permeability and writhing test in ICR mice. For anti-pyretic activities, an LPS-induced pyrexia study was conducted in rabbits. To evaluate the anti-histamine activity, we examined compound 48/80-induced systemic anaphylaxis in ICR mice and the release of β-hexosaminidase on rat basophilic leukemia (RBL-2H3) cells. Results: Ephedrae herba, Forsythiae fructus, Cinnamomi ramulus, and Cimicifugae rhizome showed potent free-radical scavenging activities. Gentianae macrophyllae radix inhibited acetic acid-induced vascular permeability. Schizonepetae spica and Cimicifugae rhizome inhibited acetic acid. Cinnamomi ramulus and Angelicae decursivae radix inhibited LPS-induced pyrexia. Angeliace dahuricae radix and Asari radix inhibited compound 48/80. Scutellariae radix, Cinnamomi ramulus, Ephedrae herba, and Zingiberis rhizoma crudus potently inhibited the release of β-hexosaminidase. Conclusions: We examined the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines; Codonopsis pilosulae radix, Zingiberis rhizoma crudus, and Cinnamomi ramulus showed novel efficacy. These results suggest that some of herbal medicines may be very effective in treating common cold.

Abstract

Objectives: To investigate the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines to test their efficacy in common cold treatment. Methods: For all experiments, the herbal medicines were extracted with 80% ethanol and freeze-dried. To determine the anti-oxidative properties, we tested DPPH-free radical-scavenging activity and xanthine oxidase inhibitory activity. To determine anti-inflammatory and analgesic potential, we investigated acetic acid-induced vascular permeability and writhing test in ICR mice. For anti-pyretic activities, an LPS-induced pyrexia study was conducted in rabbits. To evaluate the anti-histamine activity, we examined compound 48/80-induced systemic anaphylaxis in ICR mice and the release of β-hexosaminidase on rat basophilic leukemia (RBL-2H3) cells. Results: Ephedrae herba, Forsythiae fructus, Cinnamomi ramulus, and Cimicifugae rhizome showed potent free-radical scavenging activities. Gentianae macrophyllae radix inhibited acetic acid-induced vascular permeability. Schizonepetae spica and Cimicifugae rhizome inhibited acetic acid. Cinnamomi ramulus and Angelicae decursivae radix inhibited LPS-induced pyrexia. Angeliace dahuricae radix and Asari radix inhibited compound 48/80. Scutellariae radix, Cinnamomi ramulus, Ephedrae herba, and Zingiberis rhizoma crudus potently inhibited the release of β-hexosaminidase. Conclusions: We examined the anti-inflammatory, analgesic, anti-pyretic and anti-histamine activities of 20 herbal medicines; Codonopsis pilosulae radix, Zingiberis rhizoma crudus, and Cinnamomi ramulus showed novel efficacy. These results suggest that some of herbal medicines may be very effective in treating common cold.

참고문헌 (56)

  1. Gonzales R, "Excessive antibiotic use for acute respiratory infections in the United Sattes", Clin Infect Dis, 33(6), pp.757~762 (2001)
  2. Benson V, "Current estimates from the National Health Interview Survey, 1995", Vital Health Stat 10, 199, pp.1~428 (1998)
  3. 건강보험심사평가원, "통계지표", ~ (2013)
  4. 박양춘, "풍한형 및 풍열형 감모에 대한 소청룡탕의 효과- 이중맹검, 위약대조군연구", 동의생리병리학회지, 19(2), pp.524~529 (2005), 한의병리학회
  5. 배한호, "감기에 대한 연교패독산의 유효성 평가를 위한 community-based 이중맹검 위약 대조군 연구", 동의생리병리학회지, 22(1), pp.234~245 (2008), 한의병리학회
  6. 허정원, "소양인 형방패독산의 항염증효과에 대한 실험적 연구", 동의생리병리학회지, 23(2), pp.443~451 (2009), 한의병리학회
  7. 남봉수, "蔘蘇飮과 蔘蘇飮加味方의 항알레르기효과에 관한 실험적 연구", 대한안이비인후피부과학회지, 15(1), pp.343~355 (2002)
  8. 이승언, "蔘蘇飮의 항알레르기 效果", 대한한방내과학회지, 26(1), pp.1~15 (2005), 대한한방내과학회
  9. Su-Jin Kim, "Samsoeum inhibits systemic anaphylaxis and release of histamine, cytokine in vivo and in vitro", Oriental Pharmacy and Experimental Medicine, 9(2), pp.115~127 (2009), 한의학연구소
  10. 문영희, "九味羌活湯의 소염⋅진통작용", 생약학회지, 30(1), pp.18~24 (1999)
  11. 양태규, "葛根湯과 加味葛根湯의 항알레르기 및 소염, 해열, 진통작용에 대한실험적 연구", 대한안이비인후피부과학회지, 15(1), pp.76~95 (2002)
  12. 이주은, "防風葛根湯의 항알레르기효과에 관한 연구", 동의생리병리학회지, 21(5), pp.1118~1126 (2007), 한의병리학회
  13. 김동희, "Gamipaidok-san Possesses Antiallergic and Anti-inflammatory Activities", 동의생리병리학회지, 19(6), pp.1659~1665 (2005), 한의병리학회
  14. 곽상호, "淸肺化痰湯의 抗炎作用에 대한 實驗的 硏究", 대한한방부인과학회지, 20(1), pp.148~158 (2007), 대한한방부인과학회
  15. 김형갑, "葛根解肌湯의 항 Allergy 및 항염증 효과", 동의생리병리학회지, 23(2), pp.381~388 (2009), 한의병리학회
  16. 류지효, "Anti-allergic Effect of Seungmagalgeun-tang through Suppression of NF-κB and p38 Mitogen-Activated Protein Kinase Activation in the RBL-2H3 Cells", 동의생리병리학회지, 22(6), pp.1572~1578 (2008), 한의병리학회
  17. 이진아, "한약 처방 25종에 대한 항염증 효능 비교 연구", 대한한방부인과학회지, 23(3), pp.101~111 (2010), 대한한방부인과학회
  18. 전국 한의과대학 폐계내과학교실, "동의폐계내과학", pp.136~142 (2013), 나도
  19. Brand-Williams W, "Use of a free radical method to evaluate antioxidant activity", LWT - Food Sci and Tech, 28, pp.25~30 (1995)
  20. Parejo IF, "Comparison between the radical scavenging activity and antioxidant activity of six distilled and nondistilled Mediterranean herbs and aromatic plants", J Agric Food Chem, 50, pp.6882~6890 (2002)
  21. Rauf A, "Antipyretic and antinociceptive activity of Diospyros lotus L. in animals", Asian Pac J Trop Biomed, 4, pp.382~386 (2014)
  22. Ojha D, "Anti-Inflammatory Activity of Odina wodier Roxb, an Indian Folk Remedy, through Inhibition of Toll-Like Receptor 4Signaling Pathway", Plos One, 25(9), pp.e104939~ (2014)
  23. Patel MK, "Evaluation of anti-inflammatory, analgesic, and antipyretic effects of ethanolic extract of Pedalium murex Linn. fruits", Afr J Tradit Complement Altern Med, 16(10), pp.94~100 (2013)
  24. Huang F, "Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenine", International Immunopharmacology, 8(3), pp.502~507 (2008)
  25. El-Agamy DS, "Anti-allergic effects of nilotinib on mast cell-mediated anaphylaxis like reactions", Eur J Pharmacol, 680, pp.115~121 (2012)
  26. 장지문, "현대 임상 온병학", pp.218~ (2014), 청홍
  27. 조형준, "桑白皮가 항알러지 및 항염증반응에 미치는 영향", 대한한방소아과학회지, 19(2), pp.175~195 (2005), 대한한방소아과학회
  28. 송호준, "麻黃의 기도과민반응의 효과", 대한본초학회지, 20(4), pp.69~76 (2005), 대한본초학회
  29. Mossad SB, "Current and future therapeutic approaches to the common cold", Expert Rev Anti Infect Ther, 3(4), pp.619~626 (2003)
  30. 전국 한의과대학 공동교재편찬위원회, "본초학", pp.105~ (2006), 영림사
  31. 박히준, "계지의 항염 효과에 관한 연구", 대한한의학회지, 26(2), pp.140~151 (2005), 대한한의학회
  32. 이도연, "강활과 방풍의 항염증 상승작용에 관한 연구", 대한본초학회지, 23(4), pp.39~44 (2008), 대한본초학회
  33. 유진수, "비만세포 매개알레르기 모델에서 荊芥의 항알레르기 효과", Natural Product Sciences, 17(3), pp.239~244 (2001)
  34. 박종화, "비만세포 매개염증반응에 미치는 白芷(Anglicae dahuricae radix)의 억제효과", Oriental Pharmacy and Experimental Medicine, 5(3), pp.188~194 (2005)
  35. 김경수, "Regulatory Effect of Inflammatory Reaction by Asiasari Radix", 동의생리병리학회지, 19(3), pp.779~784 (2005), 한의병리학회
  36. 정진부, "Anti-Inflammatory Effects of Ethyl Acetate Fraction from Cnidium officinale Makino on LPS-Stimulated RAW 264.7 and THP-1 Cells", 한국자원식물학회지, 25(3), pp.299~307 (2012), 한국자원식물학회[DOI]
  37. 서형식, "靑黛와 生地黃의 항염 및 항산화 효과에 대한 실험적 연구", 한방안이비인후피부과학회지, 21(3), pp.104~110 (2008), 대한한방안이비인후피부과학회
  38. 신광식, "生地黃 추출물이 DNCB로 유발된 생쥐의 Allergy성 접촉피부염에 미치는 영향", 대한한의학방제학회지, 8(1), pp.257~279 (2000)
  39. 정희재, "杏仁과 桔梗이Asthma model 내의 Cytokine IL-4, IL-5, IL-6에 미치는 영향", 대한한방내과학회지, 21(1), pp.31~38 (2000)
  40. 송재진, "半夏가 천식모델 생쥐의 면역세포 및 사이토카인에 미치는 영향", 대한한방내과학회지, 26(1), pp.1~15 (2005), 대한한방내과학회
  41. 조희창, "秦艽가 항염 효과에 미치는 영향", 한방안이비인후피부과학회지, 22(3), pp.63~70 (2009), 대한한방안이비인후피부과학회
  42. 이송진, "忍冬추출물에 대한 항염증 및진통작용의 비교", 생약학회지, 25(4), pp.363~367 (1994)
  43. 곡정강, "連翹의 LPS로 유도된 Raw 264.7 Cell에서의 抗炎症 효과", 대한한방내과학회지, 31(2), pp.242~253 (2010), 대한한방내과학회
  44. 김성윤, "연교 추출물의 Microglia에서 LPS에 의해 유도되는 염증매개물질 생성 억제 효과", 대한본초학회지, 23(3), pp.93~102 (2008), 대한본초학회
  45. 황대룡, "행인의 알레르기 천식 효과에 대한 연구", 대한본초학회지, 18(2), pp.20~208 (2003), 대한본초학회
  46. 김홍배, "갈근추출액이 알레르기 염증반응에 미치는 영향", 대한한방소아과학회지, 23(3), pp.217~231 (2009), 대한한방소아과학회
  47. 신태용, "升麻 추출물의 항알레르기 효과", 약학회지, 42(4), pp.403~407 (1998)
  48. 정흥식, "升麻추출물이 RBL-2H3 Cell과 Mouse에 미치는 항알레르기 효과", 동의생리병리학회지, 20(2), pp.404~409 (2006), 한의병리학회
  49. 임혜림, "전호(Anthriscus sylvestris) 뿌리 정유의 항균 및 항산화 작용", 약 학 회 지, 56(5), pp.320~325 (2012), 대한약학회
  50. Ratnam DV, "Role of antioxidants in prophylaxis and therapy: A pharmaceutical perspective", J Control Release, 113(3), pp.189~207 (2006)
  51. Rajendran P, "Antioxidants and human diseases", Clin Chim Acta, 436, pp.332~347 (2014)
  52. Joong-Keun Lee, "Analgesic and Anti-Inflammatory Effect of Scutellaria baicalensis", 대한한의학회지, 28(4), pp.124~135 (2007), 대한한의학회
  53. Stone KD, "IgE, mast cells, basophils, and eosinophils", J Allergy Clin Immunol, 125, pp.73~80 (2010)
  54. Ma HT, "Regulation of Ca2+signaling with particular focus on mast cells", Crit Rev Immunol, 29, pp.155~186 (2009)
  55. Galli SJ, "Mast cells as “tunable" effector and immunoregulatory cells: recent advances", Annu Rev Immunol, 23, pp.749~786 (2005)
  56. Karmouty-Quintana H, "In vivo pharmacological evaluation of compound 48", 80-induced airways oedema by MRI, 2008, pp.154, 1063~1072

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