二陳湯加味方을 투여한 불응성 위식도역류질환의 증례군 연구
Case Series of Refractory Gastroesophageal Reflux Disease Treated with Lijin-tang-gamibang
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Objectives: The purpose of this study was to investigate the efficacy of Lijin-tang-gamibang on refractory gastroesophageal reflux disease (GERD). Methods: This before-and-after study compared the first medical examination and examination at the end of medical treatment. Twelve refractory GERD patients who visited the Department of Digestive Diseases of Kyung Hee University Korean Medicine Hospital from August 14th, 2017 to October 14th, 2017, were treated with Lijin-tang-gamibang for four consecutive weeks. The clinical characteristics of refractory GERD and the efficacy of herbal medical treatment was assessed by questionnaires, the Nepean Dyspepsia Index-Korean version (NDI-K), the Korean Gastrointestinal Symptom Rating Scale (KGSRS), the Numerical Rating Scale (NRS), the Korean version of the Perceived Stress Scale (KPSS-10), the Qi Stagnation Questionnaire (QSQ), the Spleen Qi Deficiency Questionnaire (SQDQ), and the Patient Global Impression of Change (PGIC). Prolonged effects were reported upon the follow-up telephone survey two weeks after treatment. Results: After treatment with the herbal medicine Lijin-tang-gamibang, the clinical characteristics of 12 refractory GERD patients were improved, especially in terms of the most common symptoms of acid regurgitation and heartburn. Each symptom score of NDI-K, KGSRS, NRS, SQDQ, and PGIC showed significant advances. Prolonged effects were reported in NDI-K, NRS and PGIC questionnaires two weeks after treatment. Conclusions: These results suggest that Lijin-tang-gamibang is an effective treatment for refractory GERD.
Abstract
Objectives: The purpose of this study was to investigate the efficacy of Lijin-tang-gamibang on refractory gastroesophageal reflux disease (GERD). Methods: This before-and-after study compared the first medical examination and examination at the end of medical treatment. Twelve refractory GERD patients who visited the Department of Digestive Diseases of Kyung Hee University Korean Medicine Hospital from August 14th, 2017 to October 14th, 2017, were treated with Lijin-tang-gamibang for four consecutive weeks. The clinical characteristics of refractory GERD and the efficacy of herbal medical treatment was assessed by questionnaires, the Nepean Dyspepsia Index-Korean version (NDI-K), the Korean Gastrointestinal Symptom Rating Scale (KGSRS), the Numerical Rating Scale (NRS), the Korean version of the Perceived Stress Scale (KPSS-10), the Qi Stagnation Questionnaire (QSQ), the Spleen Qi Deficiency Questionnaire (SQDQ), and the Patient Global Impression of Change (PGIC). Prolonged effects were reported upon the follow-up telephone survey two weeks after treatment. Results: After treatment with the herbal medicine Lijin-tang-gamibang, the clinical characteristics of 12 refractory GERD patients were improved, especially in terms of the most common symptoms of acid regurgitation and heartburn. Each symptom score of NDI-K, KGSRS, NRS, SQDQ, and PGIC showed significant advances. Prolonged effects were reported in NDI-K, NRS and PGIC questionnaires two weeks after treatment. Conclusions: These results suggest that Lijin-tang-gamibang is an effective treatment for refractory GERD.
참고문헌 (22)
- 정혜경, "위식도역류질환 임상진료지침 개정안 2012", 대한소화기학회지, 60(4), pp.195~218 (2012), 대한소화기학회
- 남승주, "위식도역류 질환의 식도 외 증상", 대한내과학회지, 91(3), pp.257~263 (2016), 대한내과학회[DOI]
- 이용찬, "불응성 위식도역류질환에 대한 치료", 대한내과학회지, 78(3), pp.301~308 (2010), 대한내과학회
- Heo J, "Dongui Bogam", pp.1126~1166 (2002), Beobinmoonhwasa
- 김희준, "역류성식도염 유발 흰쥐에 대한 二陳湯加味方의 효과", 대한한방내과학회지, 31(1), pp.128~141 (2010), 대한한방내과학회
- 김봉석, "二陳湯加味方과 침치료를 병행한 비미란성 위식도역류질환 환자 7인 증례보고", 대한한방내과학회지, 26(4), pp.926~934 (2005), 대한한방내과학회
- Talley NJ, "Development of a new dyspepsia impact scale: the Nepean Dyspepsia Index", Aliment Pharmacol Ther, 13(2), pp.225~235 (1999)
- 조유경, "기능성 소화불량증의 삶의 질에 대한 모사프리드의 효과", 대한소화기학회지, 43(3), pp.160~167 (2004), 대한소화기학회
- Svedlund J, "GSRS-a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease", Dig Dis Sci, 33(2), pp.129~134 (1998)
- Kwon SS, "Diagnostic Validity of the Korean Gastrointestinal Symptom Rating Scale(KGSRS) in the Assessment of Gastro-Esophageal Reflux Disease", Ewha Med J, 31(2), pp.73~80 (2008)
- Cohen S, "A global measure of perceived stress", J Health Soc Behav, 24(4), pp.385~396 (1983)
- Lee EH, "Korean versions of the Perceived Stress Scale (PSS-14, 10 and 4): psychometric evaluation in patients with chronic disease", Scand J Caring Sci, 29(1), pp.183~192 (2015)
- Terasawa K, "A Western medicine practitioner’s clinical oriental medicine", pp.41~58 (1998), Jibmoondang
- 최인영, "고혈압 환자에서 혈압 조절 여부에 따른 氣血水 辨證과 삶의 질 비교", 대한한방내과학회지, 31(4), pp.880~891 (2010), 대한한방내과학회
- 오혜원, "脾氣虛證 진단평가도구 개발 연구", 대한한의학회지, 35(1), pp.157~170 (2014), 대한한의학회
- Yang SY, "Prevalence of gastroesophageal reflux disease symptoms and uninvestigated dyspepsia in Korea: a population-based study", Dig Dis Sci, 53(1), pp.188~193 (2008)
- Kim N, "The prevalence of and risk factors for erosive oesophagitis and non-erosive reflux disease: a nationwide multicentre prospective study in Korea", Aliment Pharmacol Ther, 27(2), pp.173~185 (2008)
- 김지현, "위식도역류질환의 최근 동향", 대한소화기학회지, 64(3), pp.127~132 (2014), 대한소화기학회
- 한가진, "위식도역류질환 변증도구 개발 연구", 대한한방내과학회지, 36(2), pp.122~152 (2015), 대한한방내과학회
- Lew GW, "Clinical Study of Dansambohyultang on Tan-San and Jo-Jap", Kyung Hee Medical, 2(4), pp.89~95 (1986)
- Kim DH, "Korean Medicine Pharmacology", pp.49~53 (2006), Sinilsangsa
- 박경, "二陳湯加味方의 항산화 효과를 통한 역류성 식도염 억제효과", 동의생리병리학회지, 24(3), pp.416~425 (2010), 한의병리학회