본문 바로가기
KERD
논문KCI 등재

위식도역류질환의 한약 치료에 대한 최신 임상 연구 동향 - 半夏를 중심으로 -

Recent Trends in Clinical Research on Herbal Medicine Based on Pinellia Ternata for Treatment of Gastroesophageal Reflux Disease

김경옥|정서윤|이영수|김도형|김영광|장혜연
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2020.12|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제41권 제6호|pp. 1119-1140|DOI https://doi.org/10.22246/jikm.2020.41.6.1119

0

조회

0

다운로드

2

인용

0

참고문헌

키워드

herbal medicinegastroesophageal reflux disease (GERD)traditional Chinese medicine (TCM)Pinellia ternata (半夏)
주제분류한의학

초록

Objective: The purpose of this study was to review Chinese clinical studies of the treatment of gastroesophageal reflux disease (GERD) with herbal medicine including Pinellia ternata. Methods: We searched the China National Knowledge Infrastructure (CNKI) database for clinical studies on herbal treatments including Pinellia ternata for GERD, from January 1st, 2015 to September 30th, 2019. We evaluated the risk of bias using Cochrane's risk of bias to confirm the quality of the 37 selected documents. Results: The 37 papers included high-dose and middle-dose Pinellia ternata groups. The outcome measures included treatment effectiveness rate, symptom comparisons, and endoscopy effectiveness rates or scores. In both groups, most studies showed significant improvement in the treatment group compared with the control group. The meta-analysis revealed a higher treatment effectiveness rate and a lower recurrence rate in the treatment group than in the control group. Conclusions: Comparing the treatment effect between the two groups was difficult due to the low quality of most studies. However, the results suggest that herbal remedies including Pinellia ternata showed statistically significant improvement in GERD compared to control groups.

Abstract

Objective: The purpose of this study was to review Chinese clinical studies of the treatment of gastroesophageal reflux disease (GERD) with herbal medicine including Pinellia ternata. Methods: We searched the China National Knowledge Infrastructure (CNKI) database for clinical studies on herbal treatments including Pinellia ternata for GERD, from January 1st, 2015 to September 30th, 2019. We evaluated the risk of bias using Cochrane's risk of bias to confirm the quality of the 37 selected documents. Results: The 37 papers included high-dose and middle-dose Pinellia ternata groups. The outcome measures included treatment effectiveness rate, symptom comparisons, and endoscopy effectiveness rates or scores. In both groups, most studies showed significant improvement in the treatment group compared with the control group. The meta-analysis revealed a higher treatment effectiveness rate and a lower recurrence rate in the treatment group than in the control group. Conclusions: Comparing the treatment effect between the two groups was difficult due to the low quality of most studies. However, the results suggest that herbal remedies including Pinellia ternata showed statistically significant improvement in GERD compared to control groups.

참고문헌 (60)

  1. 정혜경, "위식도역류질환 임상진료지침 개정안 2012", 대한소화기학회지, 60(4), pp.195~218 (2012), 대한소화기학회
  2. Cho YS, "Prevalence and clinical spectrum of gastroesophageal reflux :a population-based study in Asan-si, Korea", Am J Gastroenterol, 100(4), pp.747~753 (2005)
  3. 남승주, "위식도역류 질환의 식도 외 증상", 대한내과학회지, 91(3), pp.257~263 (2016), 대한내과학회[DOI]
  4. 이용찬, "불응성 위식도역류질환에 대한 치료", 대한내과학회지, 78(3), pp.301~308 (2010), 대한내과학회
  5. "비계내과학", pp.314~318 (2009), 군자출판사
  6. 한가진, "위식도역류질환 변증도구 개발 연구", 대한한방내과학회지, 36(2), pp.122~152 (2015), 대한한방내과학회
  7. 나가영, "식도 열공 탈장을 동반한 위식도역류질환 환자의 수점산합증미이진탕 1증례 보고", 대한한방내과학회지, 38(3), pp.401~407 (2017), 대한한방내과학회
  8. 김봉석, "二陳湯加味方과 침치료를 병행한 비미란성 위식도역류질환 환자 7인 증례보고", 대한한방내과학회지, 26(4), pp.926~934 (2005), 대한한방내과학회
  9. 하나연, "二陳湯加味方을 투여한 불응성 위식도역류질환의 증례군 연구", 대한한방내과학회지, 38(6), pp.1085~1095 (2017), 대한한방내과학회
  10. 황지영, "역류성 식도염에 대한 二陳湯加味方 효과 연구", 동의생리병리학회지, 23(5), pp.1073~1079 (2009), 한의병리학회
  11. 이상태, "逆流性 食道炎에 대한 二陳湯加味方 構成 個別 한약재의 效果", 대한한방내과학회지, 34(2), pp.165~177 (2013), 대한한방내과학회
  12. 박재우, "韓方治療로 호전된 비미란성 위식도 역류질환 1례", 대한한방내과학회지, 27(4), pp.991~998 (2006), 대한한방내과학회
  13. 장명웅, "역류성 식도염 유발 생쥐의 半夏瀉心湯 투여 효과에 대한 실험 연구", 대한한방내과학회지, 34(4), pp.362~374 (2013), 대한한방내과학회
  14. Kang BS, "Practical Combined Herbology", pp.464~466 (1996), Younglimsa
  15. The College of Traditional Korean Medicine Pharmacology, "Traditional Korean Medicine Pharmacology", pp.184~186 (2010), Sinil books
  16. 임흥빈, "생쥐에서 ovalbumin과 디젤배기가스 입자로 유도된 기도염증과 기도 과민성에 대한 반하 물 추출물의 항천식 효과", 대한본초학회지, 28(1), pp.65~71 (2013), 대한본초학회
  17. Yuan JL, "Clinical Observation on Treatment of 66 Cases of Gastroesophageal Reflux Disease with Banxia Houpu Decoction and Wubei Powder", World Latest Medicine Information (Electronic Version), 19(71), pp.172~173 (2019)
  18. Shu ZH, "Clinical Observation on Treatment of Reflux Esophagitis with Combination of Traditional Chinese Medicine and Western Medicine", Cardiovascular Disease Electronic J of integrated traditional Chinese and Western Medicine, 7(21), pp.162~163 (2019)
  19. Li X, "Treatment of invigorating spleen and harmonizing stomach with warming Yang and dredging diaphragm on gastro-esophageal reflux disease-an observation of 38 cases", Beijing J of Traditional Chinese Medicine, 38(6), pp.519~524 (2019)
  20. Cui L, "A study on treating gastroesophageal reflux in the integrative medicine", Clinical J of Chinese Medicine, 10(29), pp.40~41 (2018)
  21. Cao CN, "Clinical Efficacy of Banxia Xiexin Decoction and Its Effects on Anxiety and Sleep Quality of Patients with Reflux Esophagitis", J of Guangzhou University of Traditional Chinese Medicine, 35(5), pp.779~784 (2018)
  22. Wang LB, "Clinical Observation on 40 Cases of Qi-stagnation-type Reflux Esophagitis Treated by Integrative Chinese and Western Medicine", Chinese J of Ethnomedicine and Ethnopharmacy, 27(9), pp.98~99 (2018)
  23. Wu XM, "Clinical Observation on Treatment of 43 Cases of Gastroesophageal Reflux Cough with Banxia Houpu Decoction", Chinese J of Ethnomedicine and Ethnopharmacy, 27(7), pp.122~123 (2018)
  24. Liu QH., "Effect of Banxia Xiexin Decoction on Gastroesophageal Reflux Disease", Contemporary Medical Symposium, 16(8), pp.197~198 (2018)
  25. Sun G, "Clinical observation on treatment of refluxesophagitis with integrated traditional Chinese and western medicine", J of Changchun University of Chinese Medicine, 33(6), pp.948~950 (2017)
  26. Han L, "Efficacy and safety evaluation of integrated traditional Chinese and Western medicine in the treatment of reflux esophagitis", J of disease surveillance and control, 11(11), pp.909~910 (2017)
  27. Ｗei SB, "Clinical observation of the Xinkaikujiang prescriptions in treatment of non-erosive reflux disease", Chinese J of Integrated Traditional and Western Medicine, 125(10), pp.747~750 (2017)
  28. Ye Y, "Evaluation of the efficacy of self-made traditional Chinese medicine in the treatment of reflux esophagitis", China Prac Med, 12(19), pp.153~154 (2017)
  29. Lin QS, "Clinical Study on 54 Cases of Gastroesophageal Reflux Disease Treated by Combination of TCM and Western Medicine", Chin Med J Res Prac, 31(3), pp.72~74 (2017)
  30. Xiong GJ, "Effect of ShuganJiangning Chinese medicine on refluxesophagitis and its effect on motilin and prostaglandin", Modern J of Integrated Traditional Chinese and Western Medicine, 26(17), pp.1854~1860 (2017)
  31. Zhang JZ, "Analysis of clinical effects of TCM internal medicine in the treatment of gastroesophageal reflux disease", World Latest Medicne Information (Electronic Version), 16(30), pp.74~75 (2016)
  32. Qi SE, "Clinical observation on treating refluxesophagitis with the BanxiaXiexin decoction plus Cisapride", Clinical J of Chinese Medicine, 7(32), pp.68~69 (2015)
  33. Chen J, "Efficacy Evaluation of 80 Cases of Gastroesophageal Reflux in ICU Treated by Integrative Chinese and Western Medicine", J of Siehuan of Traditional Chinese Medicine, 33(11), pp.50~51 (2015)
  34. Li WH, "Treating 35 cases of refluxesophagitis in the integrative medicine", Clinical J of Chinese Medicine, 7(31), pp.103~104 (2015)
  35. Jin LJ, "Clinical Observation on Treatment of Non-erosive Gastroesophageal Reflux Disease with Self-made Jiangui Decoction", Beijing J of Traditional Chinese Medicine, 34(7), pp.566~568 (2015)
  36. Li CH, "Integrated Traditional Chinese and Western Medicine for Gastroesophageal Reflux Disease", China Prac Med, 10(8), pp.202~203 (2015)
  37. Ling YA, "Clinical Study on Method of Regulate Cold and Warm Mildly for Refractory Reflux Esophagitis of Cold and Heating Complexity Type", J of new chinese medicine, 51(8), pp.128~130 (2019)
  38. Peng HQ, "Therapeutic effect of integrated traditional Chinese and Western medicine on reflux esophagitis", J of practical traditional chinese medicine, 35(4), pp.458~459 (2019)
  39. Sun LW, "Curative Effect of Integrated Traditional Chinese and Western Medicine on Reflux Esophagitis", Chinese archives of traditional chinese medicine, 36(6), pp.1511~1514 (2018)
  40. Yu JQ, "Clinical Study on Treatment of 43 Cases of Reflux Esophagitis with Combination of Traditional Chinese Medicine and Western Medicine", Jiangsu Traditional Chinese Medicine, 50(6), pp.37~38 (2018)
  41. Fang HZ, "Treatment of 100 Cases of Gastroesophageal Reflux Disease of Liver and Stomach Stagnation and Heat by Soothing Liver and Stomach", Jiangxi Traditional Chinese Medicine, 419(48), pp.33~34 (2017)
  42. Du ZU, "Clinical Observation on Treatment of Reflux Esophagitis with Combination of Traditional Chinese Medicine and Western Medicine", J of practical traditional chinese medicine, 33(10), pp.1163~ (2017)
  43. Zheng X, "Clinical observation of traditional Chinese medicine treatment for gastro-esophageal reflux disease", Bipedal and health care, 165(7), pp.191~192 (2017)
  44. Zhao B, "Clinical efficacy of integrated traditional Chinese and Western medicine in the treatment of patients with reflux esophagitis after esophageal cancer", Drugs and Clinical, 12, pp.36~38 (2016)
  45. Ma XL, "Clinical Analysis of Integrated Traditional Chinese and Western Medicine in Treating Gastroesophageal Reflux", Trace elements and health research (2016)
  46. Fan LY, "Clinical Research on Reflux Esophagitis Treated with Liver-Dispersing, Stomach-Harmoning and Adverse-Rising-Descending Decoction", Henan traditional chinese medicine, 36(11), pp.1949~1951 (2016)
  47. Ren TK, "Therapeutic effect of Jiawei Xiaozhantang Decoction on reflux esophagitis", Chinese J Mod Drug Appl, 10(17), pp.266~267 (2016)
  48. Long Y, "Clinical observation of Fangtong Jiangshu Decoction in the treatment of hepatic and gastric disharmony gastroesophageal reflux disease", Asia-Pacific Traditional Medicine, 12(16), pp.152~153 (2016)
  49. Geng CH, "Clinical Effect and Mechanism on Patients with Liver Stomach Heat Stagnation Type Gastro-esophageal Reflux Disease Treated with JiaweiXuanfuDaizhe Decoction", J of Liaoning university of TCM, 18(9), pp.177~180 (2016)
  50. Jin HY, "Clinical Observation on Treatment of Liver-Stomach Stagnation and Heat Reflux Esophagitis with Dan Xiaoyao San", J of Sichuan of Traditional Chinese Medicine, 34(4), pp.127~129 (2016)
  51. Jiang L, "Observation on the Therapeutic Effect of Integrated Traditional Chinese Medicine and Western Medicine on Gastric Esophageal Reflux Disease", J of practical traditional chinese medicine, 32(3), pp.223~ (2016)
  52. Liu WB, "Clinical Observation on Treatment of Gastroesophageal Reflux Disease with Combination of Traditional Chinese Medicine and Western Medicine", J of practical traditional chinese medicine, 32(3), pp.221~ (2016)
  53. Fu YP, "Clinical Observation on 45 Cases of Gastroesophageal Reflux Disease Treated by Combination of Traditional Chinese Medicine and Western Medicine", J of new chinese medicine, 47(3), pp.76~78 (2015)
  54. 최가영, "역류성 식도염의 변증과 처방에 관한 문헌적 고찰 - 중국 논문 중심으로 -", 대한한방내과학회지, 32(1), pp.75~86 (2011), 대한한방내과학회
  55. 김근홍, "역류성 식도염에서의 二陳湯加味方의 효과에 대한 문헌적 고찰", 한의학연구소 논문집, 22(1), pp.119~128 (2013), 한의학연구소
  56. 정유진, "중국 및 한국 Database에서의 위식도 역류질환에 대한 반하사심탕의 효과에 대한 최근 10년간의 연구경향", 대한한방내과학회지, 41(3), pp.362~413 (2020), 대한한방내과학회[DOI]
  57. Howden CW, "a Gastric 'Proton pump Inhibitor' : Lack of Effect on Renal Handling of Electrolytes and Urinary Acidification", Europe J Clin Pharmacology, 26(5), pp.639~640 (1984)
  58. Im WB, "Omeprazole, a Specific Inhibitor of Gastric (H-K)-ATPase", J Biol Chem, 260(8), pp.4591~4597 (1985)
  59. Kim DH, "Standard Principles for the Designing of Prescription - The Theory for Monarch, Minister, Adjuvant and Dispatcher", The Korean J of Oriental Medical Prescription, 11(2), pp.1~18 (2003)
  60. 이태경, "君臣佐使에 대한 연구", 동의생리병리학회지, 21(3), pp.596~604 (2007), 한의병리학회

관련 논문AI추천

중국 및 한국 Database에서의 위식도 역류질환에 대한 반하사심탕의 효과에 대한 최근 10년간의 연구경향김윤정, 정유진, 홍상훈대한한방내과학회 · 대한한방내과학회지2020 · 제41권 제3호위식도역류질환에 대한 반하후박탕의 효과 : 체계적 문헌고찰과 메타분석강시은, 김경민, 진명호대한예방한의학회 · 대한예방한의학회지2022 · 제26권 제2호위식도역류질환 한약제제 임상시험 가이드라인 개발을 위한 관련 국내 가이드라인 분석 및 기존 한약임상시험과의 비교김진성, 이준희, 임정태, 한가진대한한방내과학회 · 대한한방내과학회지2016 · 제37권 제1호역류성 식도염의 변증과 처방에 관한 문헌적 고찰 - 중국 논문 중심으로 -고재언, 김병우, 선승호, 오현석, 이선주, 최가영, 한인식대한한방내과학회 · 대한한방내과학회지2011 · 제32권 제1호二陳湯加味方을 투여한 불응성 위식도역류질환의 증례군 연구고석재, 김대준, 김진성, 박재우, 하나연, 한가진대한한방내과학회 · 대한한방내과학회지2017 · 제38권 제6호Herbal Medicine for the Treatment of Non-Erosive Reflux Disease: A Systematic Review and Meta-Analysis Protocol고석재, 김민정, 김진성, 박재우, 박채현대한한방내과학회 · 대한한방내과학회지2023 · 제44권 제6호

이 간행물의 다른 논문 (30건)

한약복용이 간기능에 미치는 영향 : 국내 문헌에 대한 체계적 고찰제유란, 박상은, 김경림, 하다정pp. 933-946파킨슨병 환자의 통증에 대한 한의치료의 효과 : 후향적 연구김서영, 박성욱, 권승원, 정혜선, 임태빈, 정우상, 박정미, 조승연, 문상관, 진철, 고창남, 김하리pp. 947-958한약 임상시험의 특성 : 질병관리본부 임상연구정보서비스(CRIS)를 중심으로전선우, 조희근, 정창운pp. 959-966오가피청혈플러스가 NF-κB 및 MAPKs 신호전달체계와 혈관부착인자 등에 미치는 영향배지은, 유호룡, 김윤식, 최규철, 설인찬, 이지원pp. 967-983임상한의학 실시간 비대면교육의 평가를 위한 설문조사 연구양승보pp. 984-992
원문 보기