Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
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Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertalbulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexualdevelopment and spermatogenic function. The objective of this study was to evaluate the association betweensingle nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. FourSNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers andpuberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and pubertyage estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of anassociation of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidalregulation in bovine sexual development and arrival to puberty.
Abstract
Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertalbulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexualdevelopment and spermatogenic function. The objective of this study was to evaluate the association betweensingle nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. FourSNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers andpuberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and pubertyage estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of anassociation of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidalregulation in bovine sexual development and arrival to puberty.
참고문헌 (25)
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