한방치료 후 NK세포 활성도의 호전을 보인 암환자 증례보고 3례
3 Cases of Cancer Patients Whose Natural Killer Cell Activity Improved with Traditional Korean Medicine Treatment: A Case Series
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: High natural killer cell activity (NKA) is associated with a clinically favorable status in patients with cancer. This study explores whether traditional Korean medicine (TKM) improves NKA in patients with cancer. Methods: We report three clinical cases involving patients with cancer who underwent NKA tests while they received TKM treatment, including acupuncture, moxibustion, wild ginseng pharmacopuncture, and Korean herbal medicines. We analyzed the treatment process and NKA test results of each patient. Results: The NKA of all three patients presented with an increasing tendency during the treatment process. Patient 1, who had been diagnosed with breast cancer, received inpatient treatment 3 times between September 16, 2017 and February 27, 2019. The NKA increased from 7.2 pg/mL to 571.7 pg/mL. Patient 2, who had thyroid cancer, was hospitalized 4 times between July 23, 2019 and August 27, 2020. The NKA improved from 317.4 pg/mL to 2000 pg/mL. Patient 3, who had liver cancer, received inpatient treatment 4 times between May 27, 2016 and January 10, 2017. The NKA increased from 22.2 pg/mL to 459.5 pg/mL. The chief complaints of these patients also were alleviated. Conclusions: TKM may be an effective treatment for accelerating NKA. Further research is needed to establish evidence that TKM stimulates NKA.
Abstract
Objectives: High natural killer cell activity (NKA) is associated with a clinically favorable status in patients with cancer. This study explores whether traditional Korean medicine (TKM) improves NKA in patients with cancer. Methods: We report three clinical cases involving patients with cancer who underwent NKA tests while they received TKM treatment, including acupuncture, moxibustion, wild ginseng pharmacopuncture, and Korean herbal medicines. We analyzed the treatment process and NKA test results of each patient. Results: The NKA of all three patients presented with an increasing tendency during the treatment process. Patient 1, who had been diagnosed with breast cancer, received inpatient treatment 3 times between September 16, 2017 and February 27, 2019. The NKA increased from 7.2 pg/mL to 571.7 pg/mL. Patient 2, who had thyroid cancer, was hospitalized 4 times between July 23, 2019 and August 27, 2020. The NKA improved from 317.4 pg/mL to 2000 pg/mL. Patient 3, who had liver cancer, received inpatient treatment 4 times between May 27, 2016 and January 10, 2017. The NKA increased from 22.2 pg/mL to 459.5 pg/mL. The chief complaints of these patients also were alleviated. Conclusions: TKM may be an effective treatment for accelerating NKA. Further research is needed to establish evidence that TKM stimulates NKA.
참고문헌 (32)
- 홍세리, "Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2017", Cancer Research and Treatment, 52(2), pp.335~350 (2020), 대한암학회
- 통계청 인구동향과, "2018년 사망원인통계", 대한의사협회지, 63(5), pp.286~297 (2020), 대한의사협회
- Yoon SW, "Cancer prevention and therapy:Integrating traditional Korean medicine into modern cancer care", Integr Cancer Ther, 13(4), pp.310~331 (2014)
- Bae K, "The effectiveness of anticancer traditional Korean medicine treatment on the survival in patients with lung, breast, gastric, colorectal, hepatic, uterine, or ovarian cancer:A prospective cohort study protocol", Medicine, 97(41), pp.e12444~ (2018)
- Park JH, "A literature study on oncological immune therapy", Journal of Haehwa Medicine, 9(2), pp.211~221 (2001)
- Kim HS, "Natural killer cell and cancer Immunotherapy", Hanyang Med Rev, 33(1), pp.59~64 (2013)
- Spits H, "The expanding family of innate lymphoid cells:Regulators and effectors of immunity and tissue remodeling", Nat Immunol, 12(1), pp.21~27 (2011)
- Chan CJ, "Molecular mechanisms of natural killer cell activation in response to cellular stress", Cell Death Differ, 21(1), pp.5~14 (2014)
- Smyth MJ, "New aspects of natural-killer-cell surveillance and therapy of cancer", Nat Rev Cancer, 2(11), pp.850~861 (2002)
- Hansen TF, "Correlation between natural killer cell activity and treatment effect in patients with disseminated cancer", Transl Oncol, 12(7), pp.968~972 (2019)
- Tang YP, "Prognostic value of peripheral blood natural killer cells in colorectal cancer", BMC Gastroenterol, 20(1), pp.1~8 (2020)
- Jobin G, "Association between natural killer cell activity and colorectal cancer in high-risk subjects undergoing colonoscopy", Gastroenterology, 153(4), pp.980~987 (2017)
- Imai K, "Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence:an 11-year follow-up study of a general population", Lancet, 356(9244), pp.1795~1799 (2000)
- Oken MM, "Towncology Group", Am J Clin Oncol, 5(6), pp.649~655 (1982)
- 탁원영, "Clinical Significance of Serum HBsAg Titer", Single Topic Symposium, 2014(1), pp.1~8 (2014)
- Castriconi R, "NK cells recognize and kill human glioblastoma cells with stem cell-like properties", J Immunol, 182(6), pp.3530~3539 (2009)
- "NK Vue®kit range of application"[URL]
- Lee HS, "Peripheral natural killer cell activity is associated with poor clinical outcomes in pancreatic ductal adenocarcinoma", J Gastroenterol Hepatol, 36(2), pp.516~522 (2021)
- Kang HJ, "Correlation between natural killer cell activity and systemic inflammatory markers for heterogeneous cancer patients treated with Wheel Balance Cancer Therapy", Integr Cancer Ther, 17(2), pp.322~331 (2018)
- Jeung-won Yoon, "Changes in the Laboratory Data for Cancer Patients Treated with Korean-medicine-based Inpatient Care", Journal of Pharmacopuncture, 17(1), pp.20~26 (2014), 대한약침학회[DOI]
- Johnston MF, "Acupuncture may stimulate anticancer immunity via activation of natural killer cells", Evidence-based Complement Altern Med, 2011, pp.481625~ (2011)
- Qiu X, "Effects of moxibustion at Shenque (CV 8) on serum IL-12 level and NK cell activities in mice with transplanted tumor", J Tradit Chinese Med, 24(1), pp.56~58 (2004)
- 대한약침학회 학술위원회, "약침학", pp.229~246 (2011), 엘스비어코리아
- 조병준, "Colon26-L5 대장암 세포를 이용한 간전이 모델에 산삼약침 처치가 혈 중 cytokine에 미치는 영향", Journal of Pharmacopuncture, 9(1), pp.127~137 (2006), 대한약침학회
- 박봉기, "6개월간 산삼약침요법을 시행받은 ⅢB기 편평세포폐암 환자에 대한 증례보고", Journal of Pharmacopuncture, 10(3), pp.143~147 (2007), 대한약침학회
- Goodrich SK, "Use of artemisinin and its derivatives to treat HPV-infected", transformed cells and cervical cancer:A review, 2014, pp.10(4), 647~654
- -gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice, "Cancer Lett", 1998, 139~144
- Jun HJ, "The survival benefit of combination therapy with mild temperature hyperthermia and an herbal prescription of Gun-Chil-Jung in 54 cancer patients treated with chemotherapy or radiation therapy:a retrospective study", Integr Cancer Ther, 19, pp.1872145015~ (2020)
- 유화승, "각종 암환자 69례에 대한 항전이 및 재발억제 효과", 대한한방내과학회지, 23(2), pp.165~173 (2002), 대한한방내과학회
- Park HR, "Inhibition of lung cancer growth by HangAmDan-B is mediated by macrophage activation to M1 subtype", Oncol Lett, 13(4), pp.2330~2336 (2017)
- Yim MH, "Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes", Acta Pharmacol Sin, 28(6), pp.901~907 (2007)
- Xue X, "Comparison of clinical features and outcomes between HBV-related and non-B non-C hepatocellular carcinoma", Infect Agent Cancer, 15(1), pp.1~6 (2020)