한의치료 후 진행성 암환자의 삶의 질 및 면역 관련 지표 변화: 후향적 차트 리뷰
Improvement in Quality of Life and Immune-Related Markers in Advanced Cancer Patients after Korean Medicine Treatment: A Retrospective Chart Review
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Objectives This study investigated the impact of Korean medicine treatments on quality of life and immune-related hematologic indicators in patients with advanced cancer. Methods The study involved patients diagnosed with stage III or IV cancer who were admitted to a Korean medicine hospital from 2021 to 2024. These patients underwent quality-of-life assessments using the EORTC QLQ-C15-PAL(European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 for Palliative Care) at admission and discharge, coupled with blood tests analyzing immune markers such as NLR(neutrophil-to-lymphocyte ratio), MLR(monocyte-to-lymphocyte ratio), and PLR(platelet-to-lymphocyte ratio). Paired t-tests were conducted to compare pre- and post-treatment results. Results Among 15 patients, significant improvement was observed in total QoL scores after Korean medicine treatment (p=0.017), with notable enhancements in fatigue, weakness, and sleep quality. While trends indicated stabilization of immune markers (e.g., reduction in NLR from 3.57 to 3.23), changes were not statistically significant. Conclusions Korean medicine treatments contributed to improved QoL, particularly in alleviating fatigue and sleep disturbances. Though immune marker changes were observed, further studies with larger samples are needed to substantiate these findings.
Abstract
Objectives This study investigated the impact of Korean medicine treatments on quality of life and immune-related hematologic indicators in patients with advanced cancer. Methods The study involved patients diagnosed with stage III or IV cancer who were admitted to a Korean medicine hospital from 2021 to 2024. These patients underwent quality-of-life assessments using the EORTC QLQ-C15-PAL(European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 for Palliative Care) at admission and discharge, coupled with blood tests analyzing immune markers such as NLR(neutrophil-to-lymphocyte ratio), MLR(monocyte-to-lymphocyte ratio), and PLR(platelet-to-lymphocyte ratio). Paired t-tests were conducted to compare pre- and post-treatment results. Results Among 15 patients, significant improvement was observed in total QoL scores after Korean medicine treatment (p=0.017), with notable enhancements in fatigue, weakness, and sleep quality. While trends indicated stabilization of immune markers (e.g., reduction in NLR from 3.57 to 3.23), changes were not statistically significant. Conclusions Korean medicine treatments contributed to improved QoL, particularly in alleviating fatigue and sleep disturbances. Though immune marker changes were observed, further studies with larger samples are needed to substantiate these findings.
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